Recently, the General Secretary of the Supreme Leader attended the forum on cultural inheritance and development and delivered an important speech, stressing the need to adhere to integrity and innovation, to maintain the integrity and spirit of integrity and innovation, to continue the historical context and write contemporary Chinese chapters. China’s excellent traditional culture is the spiritual wealth that shines forever on China’s land. It has both the spiritual code of "where we came from" and the spiritual signpost of "where we are going". We should strengthen our cultural self-confidence, take on the mission and work hard in innovation, and continue to promote cultural prosperity, build a cultural power and build a modern civilization of the Chinese nation at a new historical starting point.

　　Defending is the foundation. Chinese excellent traditional culture is the spiritual lifeline of the Chinese nation and an important source of cultivating socialist core values. From the political ambition of "worrying about the world first, and enjoying the world later" to the patriotic feeling of "striving for the country’s life and death, why not avoid it because of misfortune and happiness", from the lofty righteousness of "wealth can’t be lewd, poverty can’t be moved, and power can’t be bent" to the sacrifice of life for righteousness of "who has never died since ancient times, keeping a fresh heart to shine on history", China’s excellent traditional culture has always inspired Chinese sons and daughters. The tree height thousands of feet has roots, and the water flow Wan Li is active. In today’s situation of profound economic and social development and changes, and diverse values, we should strengthen our historical consciousness, strengthen our cultural self-confidence, learn from classics and traditions, consciously use Bacon, an excellent Chinese traditional culture, to cast souls, enlighten our minds and moisten our hearts, and unite the spiritual strength of all people who work hard and move forward with one heart and one mind.

　　Innovation is the key. The value of culture lies not only in adhering to traditional excellent culture, but also in spreading with the times. Whether it is the popularity of variety shows such as China in Classics and National Treasures or the popularity of adapted dance programs such as Dancing for the Millennium and Only Green, it is the creative transformation and innovative development of Chinese excellent traditional culture, which makes the excellent traditional culture rooted in history shine new light in the new era. Today, facing the new situation at home and abroad, the new situation in the ideological field and the new trend of information technology development, it is more necessary than ever to innovate to inherit and carry forward the excellent Chinese traditional culture. We should rely on the power of the Internet and use market-oriented means to develop more carriers and scenes to spread excellent traditional culture, so that it can enter modern life and blend into the homes of ordinary people, and constantly create new glory of Chinese culture from "broken circle" to "out of circle" and from "alive" to "on fire".

　　Only by adhering to integrity can innovation have a clear position and direction; Only by constantly innovating and being upright can we get the source of vitality and the foundation of power. One of the important reasons why the Chinese nation has stood firm and courageously advanced in the torrent of history is that generations of Chinese sons and daughters have cultivated and developed a unique and profound Chinese culture in the process of integrity and innovation, which has provided a strong spiritual support for the Chinese nation to overcome difficulties and live endlessly. The wisdom and essence of Chinese excellent traditional culture have permeated all aspects of governing the country, from "people first, life first" to "Lucid waters and lush mountains are invaluable assets". Facing the future, we should organically combine upholding and developing Marxism with carrying forward China’s excellent traditional culture, unswervingly follow the road of Socialism with Chinese characteristics, and constantly push the cause of the Party and the country to a new level.

　　Cultural prosperity leads to national prosperity, while strong culture leads to strong nation. Firmly holding the "root" and "soul" of Chinese excellent traditional culture, always rooting in the fertile soil of Chinese culture and constantly absorbing the nourishment of innovative practice, we will surely gather the majestic cultural forces and strive to write a new chapter in building a socialist modern country in an all-round way. (Author: Lin Yunpeng)

　　CCTV News:In the past few days, many places in the country have ushered in the peak of returning home. According to the data of the smart car networking platform of the State Grid, as of February 5, the charging amount of new energy vehicles in the expressway service area on the platform has increased by more than 60% compared with the same period of last year. With more and more new energy vehicles joining the returning army, the "travel tide" has formed, and the "charging tide" of new energy vehicles has also appeared.

　　The data shows that in the 11 days from January 26th in Spring Festival travel rush to February 5th, the charging amount of new energy vehicles in the expressway service area reached 34,089,100 kWh, and the charging times reached 1,519,400, which were 67.06% and 48.42% higher than that in Spring Festival travel rush in 2023, respectively.

　　According to the platform data, during the Spring Festival travel rush in 2024, the peak period of the whole high-speed busy index reached 30%— 40%, which shows that among all the stations on the expressway, there are 30%— 40% of the stations are fully charged. At ordinary times, the charging busy degree of these stations is only about 10%, and the busy degree has doubled or tripled, showing an obvious tidal phenomenon.

　　Emergency charging compartment of mobile charging vehicle should deal with "charging tide"

　　In view of the "charging tide" brought by the "travel tide" of new energy vehicles, during the period of Spring Festival travel rush, many places in China took various measures to solve this problem.

　　It is predicted that during the Spring Festival in 2024, the average daily charging capacity of Jiangsu expressway service area will reach 600,000 kWh, a year-on-year increase of 70%, a record high. In order to alleviate the charging pressure, Taizhou power supply department has reformed 7 service areas and 14 charging stations within its jurisdiction, and equipped mobile charging vehicles. In Qinhu service area on Yanjing Expressway, a 120kW mobile charging vehicle is specially equipped, which can provide uninterrupted charging service for four electric vehicles at the same time.

　　In Pingwang Service Area, Wujiang District, Suzhou City, there are 16 charging parking spaces in the north-south direction. Since Spring Festival travel rush, affected by high-speed tidal phenomenon, eight charging parking spaces on the north side of the service area are basically full every day, but there are vacant parking spaces on the south side. Local staff guided some cars on the side with large traffic flow to the opposite idle service area for charging through the two-way culvert, which effectively improved the bearing capacity of the service area.

　　In Tianjin, in order to reduce the waiting time for new energy vehicle owners to charge on expressways, the local electric power department started the emergency charging cabin in the expressway service area on the one hand, and upgraded the charging facilities of 46 busy high-speed charging stations in advance. After the renovation, the average charging time was shortened by nearly 30%.

　　Scientific layout to ease the expressway "Charging tide"phenomenon

　　China has been speeding up the layout of charging piles, so that electric vehicles can alleviate the "energy-filling anxiety" of expressways. In the future, this phenomenon of "charging tide" is expected to be alleviated with the increasingly intelligent and efficient energy-replenishing network of expressways being gradually woven.

　　According to the data of the Ministry of Transport, at present, there are more than 20,000 charging piles in expressway service areas nationwide, covering nearly 50,000 parking spaces for minibuses. The coverage rate of charging facilities in expressway service areas in Beijing, Liaoning, Jilin, Shanghai, Zhejiang, Hunan and Xinjiang has reached 100%.

　　According to the data of China Electric Vehicle Charging Infrastructure Promotion Alliance, at present, the increment ratio of piles to vehicles is 1:2.5, and the construction of charging infrastructure can basically meet the rapid development of new energy vehicles. Experts say that highway charging piles are usually idle and not enough for holidays. To solve this "tidal" problem, we should not just consider the increment, but also improve the quality to ensure its economy.

　　In Liaoning, for new energy vehicle users, the local high-speed charging travel guide has been issued, so that drivers can check the layout of charging piles in advance, so as to better plan the charging line. At the same time, the local power department also accurately grasps the status of each charging pile, such as pile body, display and charging cable, through the digital platform, and problems can be solved in real time.

In the competition with the same class models, it is worth mentioning in terms of space performance. Let’s take you to appreciate its style.

Let’s take a look at the appearance of the plug-in hybrid of Lingrui. The overall appearance of the plug-in hybrid front of Lingrui is unique and looks more dynamic. Coupled with simple headlights, the visual effect is still good. The car is equipped with LED daytime running lights, automatic opening and closing, adaptive far and near light, delayed closing and so on. Come to the side of the car, the car body size is 4685MM*1935MM*1710MM, the car uses simple lines, and the side circumference gives people a very fashionable and dynamic feeling. With large-sized thick-walled tires, it gives people a very simple feeling. In the design of the rear end, the rear end and the front end echo each other from a distance, and the taillight style is relatively young and individual, creating a good gas field.

In the plug-in hybrid car, the plug-in hybrid interior looks very fashionable and elegant, highlighting the hierarchical effect. The car looks very good outside the steering wheel, and it is made of genuine leather, so it feels good. Take a look at the central control. The car is equipped with a touch-sensitive LCD central control screen with young personality, which makes the interior style impressive and conforms to the mainstream aesthetics. The dashboard and seats are equally eye-catching. The car is equipped with a simple dashboard, and the information is easy to read and clear. The car uses leather seats, which are wide and thick and very comfortable to ride.

The car is equipped with car networking, driving mode selection, remote control key, Bluetooth key, NFC/RFID key, rear wiper, interior atmosphere light and other configurations, which greatly improves the convenience of using the car.

To sum up: SUV has an atmospheric appearance, good spatial performance and high cost performance. I wonder if you are interested in it.

　　Focus on cutting-edge scientific and technological innovation and upgrading of traditional industries

　　The Industrial 4.0 Revolution sweeping the world has affected almost every industry, including the supply chain management of all industries.

　　In the past, supply chain management was a headache for all industries, because the traditional supply chain involved a lot of fuzzy and inaccessible data, which swallowed up cost, time and patience like a "black hole". Industry 4.0 will give birth to a new digital supply chain and realize more complex and streamlined supply chain management.

　　Digital supply chain is an important direction of industrial solutions and business processes in the future, including not only logistics, warehousing, transportation, but also engineering, research and development, manufacturing and asset management.

　　With the application of many innovative technologies such as artificial intelligence, Internet of Things and blockchain in the supply chain, the traditional supply chain management is rapidly moving towards digitalization, intelligence and controllability.

　　1. Cross-platform asset tracking that connects everything

　　At present, GPS positioning is a mature technology with low price and low management cost, which is widely used in various fields. Through sensors connected to various assets or vehicles, the location and general time planning of assets can be obtained.

　　Enterprises can track assets through bar codes and tracking numbers, and know where products and goods are being shipped. However, this kind of tracking and monitoring is far from accurate, and it will still bring many problems and inconveniences.

　　For example, after shopping on the e-commerce platform, the logistics information shows that "the courier is delivering the goods", but we can’t know whether the courier will deliver it within the next hour or within three hours.

　　In the industrial field, this inaccurate or delayed logistics distribution will bring some confusion to the production of enterprises, and even cause the production line to stop. Especially for manufacturers who pursue zero inventory, zero inventory not only refers to the timely delivery of final products, but also includes the inventory management of raw materials and equipment needed for production.

　　Therefore, more accurate asset tracking technology will be an important direction of digital supply chain in the future. Hans Thalbauer, senior vice president of SAP, said, "We should not only create connections for goods, but also create connections for business partners. We need to connect not only suppliers, but also suppliers of suppliers. "

　　The future digital supply chain should not only connect all links in the supply chain, but also connect all factors that affect logistics distribution, such as weather, natural disasters, road infrastructure, regional economy and even political influence, so as to minimize risks.

　　For example, last year’s hurricane, which caused great damage to the American economy, affected the distribution of some suppliers’ goods, causing some automakers to shut down production. If we can get the news from the supply chain that "my supplier’s factory in Japan is affected by the earthquake and will stop production in the next two weeks", manufacturers can purchase products from suppliers in other parts of the world in time.

　　2. Timely production and forecast monitoring

　　As early as several decades ago, Toyota Motor Corporation initiated the concept of just in time to alleviate the problem of lack of cash, land and large inventory. Through the accurate management system, the response time of suppliers is shortened and the investment in process inventory is reduced.

　　But the basis of timely production is that all parts and raw materials must arrive on time. On the automobile assembly line, the shortage of any part will affect the normal production of the production line. If the distribution of parts is delayed, it may lead to product quality problems or even downtime; If the delivery is too early, the factory is not ready to receive it, which will increase the cost of inventory management.

　　In order to meet the production needs of large manufacturers, OEM will have strict delivery response time to ensure that parts can arrive at suppliers on time. However, this will bring great production pressure to suppliers. On the one hand, suppliers have to invest a lot of money in expedited transportation, and at the same time, in order to avoid the penalty of downtime caused by delayed transportation, suppliers must also maintain a certain amount of spare parts inventory.

　　Therefore, timely production can improve the production efficiency of OEM manufacturers, but it will lead to low efficiency of suppliers, thus increasing the cost of parts.

　　This requires the future digital supply chain to have the machine learning ability of real-time prediction. Through digital connection, it can realize predictive quality management, predictive manufacturing and predictive maintenance, improve the efficiency of production and distribution, and reduce costs.

　　3. Blockchain and traceability

　　The advantages of security, trust, traceability and controllability make blockchain one of the most potential new technologies. By creating a safe and transparent ledger system, all relevant stakeholders in the supply chain, such as manufacturers, retailers, logistics service providers and regulatory agencies, are brought into the same management platform, making the whole management process credible and transparent.

　　In recent years, many start-ups that use blockchain technology to reshape supply chain management have been born. At the same time, traditional logistics giants have also begun to explore the application path of blockchain.

　　For example, the shipping giant Maersk cooperated with IBM to develop the TradeLens blockchain platform, aiming at improving logistics efficiency and simplifying the documentation of global container transportation. After testing, the handling capacity of shipping documents is reduced by 10 times, and the transportation time is reduced by 40% on average. At present, nearly 100 partners around the world have joined the platform.

　　Through opening up, blockchain technology can effectively prevent price fraud, transportation delay and payment delay, eliminate middlemen and effectively reduce transaction costs.

　　In the industrial field, although the blockchain is still in the experimental and exploratory stage, once it is deeply integrated with industrial production, it will play an important role in future industrial production and digital supply chain.

　　In the future, all kinds of new technologies will allow us to look at every link of the whole supply chain more rationally from the digital point of view, and help us to continuously improve our production, analysis, maintenance and forecasting capabilities.

　　As Hans Thalbauer, Senior Vice President of Supply Chain and Internet of Things of SAP Company said, "This is a digital mirror. It is the digital twin of products, the twin of assets and a mirror of the world. This allows us to start the dynamic adjustment process. We hope to create a digital mirror image of the real world in this environment. "

This article first appeared on WeChat WeChat official account: Capital Lab. The content of the article belongs to the author’s personal opinion and does not represent Hexun.com’s position. Investors should operate accordingly, at their own risk.

　 　 1905 movie network news The 57th Grammy Awards Ceremony was held in Los Angeles on February 8th, US local time and February 9th, Beijing time. This year’s red carpet show, Starlight Glimmer, featured many beautiful stars. Different from the past, kissing "flirting" was popular on the red carpet this year. kim kardashian and Lady GaGa kissed their male partners boldly, and Ariana Grande, a newly emerging little fresh meat, dressed up in a white dress and flirted with her male partners. Nicole Kidman, a movie star, was prescient and put her hand on her husband’s mouth to "forbid" kissing. This "show of love" is really forcing single dog to die.

　 　 Other actresses are still beautiful scenery without a male companion. Taylor Swift still remembers to show off her long legs like a model. Rihanna no longer plays cold and cold, but wears a long pink dress to look fresh. Compared with before, miley cyrus finally stopped "sticking out her tongue and revealing her milk" and wore a dress normally, but the black backless dress is sexy. Are you sure that the color meets the age of the post-90 s? Without the age advantage, Madonna, who is already "old", made a sexy appearance in a show of bursting breasts and showing her hips, Beyonce showed her "hemisphere" in a domineering black dress, paris hilton, a celebrity, showed her breasts in a long silver dress, and nicki minaj, a "spicy chicken", brushed her hair forward and turned it back. Katy Perry, the fruit elder sister, did not exaggerate the fruit shape, but dyed her purple hair instead. kaya jones was unwilling to be lonely, and combed her red buns to steal the camera. Those who don’t have "milking and dyeing their hair" can only wear an oversized long skirt to steal the mirror, but accidentally stealing the mirror is unsuccessful. Just like Princes Harris, wearing a black gauze skirt is like a black crow.

　 　 Apart from female stars, this year’s male stars are really not worth watching, but they are still worth watching for the audience in China. Lang Lang, the "Piano Prince", won glory for his country and is expected to perform at the Grammy Awards this year. Although the shape on the red carpet show is not as "stunning" as that of Zhang Jiebao, who has gone abroad before, people in this country are still very much looking forward to it.

Sam smith won four prizes and became a big winner "Fruit Sister" to accompany Grammy 7 times.

　 　 The opening song of the award ceremony was performed by Australian rock group AC/DC, and "Rock or Bust" and the classic single "High way to Hell" were played live! If ginger is still old and spicy, the audience will bring a bright little red corner to help when playing, which will stir up the atmosphere at the scene. The first award was announced by Taylor Swift, and finally sam smith won it. He was the biggest winner in this Grammy. In addition, as we all know, "Mouldy Mould" is a superstar on the stage, but it becomes a small fan in a second under the stage. No matter who performs, it is very popular to swing with the music, and this time is no exception, and it is still awkward. Later, Farrell teamed up with Lang Lang to perform the hit single "Happy". After the performance, Lang Lang also communicated with Madonna and took a photo with Jay Z. In addition, Ariana Grande, a popular female singer, performed a new single Just A Little Bit of Your Heart, which was included in her second album My Everything last year. Katy Perry, the fruit sister who accompanied the Grammy for seven times, sang a lyrical new single "By the Grace of God". After reading it, she really wanted to say, "Ask the judges for an award".

　 　 Grammy regulars Lady GaGa and old artist Tony Bennet performed the theme song Cheek to Cheek in the Top Hat by Fred Astaire, the king of jazz dance. "Ga Jie" was elegant and jazz this time, and it was retro and unplugged. Hosted by Miley and Spicy Chicken, Madonna "Tianhou" appeared on the stage, making her debut in the new album Rebelhart, featuring the first single Living For Love. Grandma Mai is now 57 years old, but her singing and dancing are still hot and sexy, and her voice is still so great! Rihanna performed their new single "Four Five Seconds" together with "Kanye" Kanye Omari West. It is worth mentioning that "Japanese woman" wore a men’s interpretation of the single. Although the pink dress was fresh on the red carpet, the performance revealed Rihanna’s nature, and the men’s clothing was still cool and cool. At the end of the day, Beyonce made a stunning finale, singing the classic gospel song "Take My Hand Precious Lord" and singing the soundtrack song "Glory" with other singers who attended the tribute.

　 　 In this Grammy nomination, British newcomer sam smith and American diva Beyonce led the way with six nominations. Among them, sam smith, who just released her first solo album, swept all the nominations for four general awards. In the last six nominations, he won four awards, including single of the year, production of the year, new artist of the year and pop album of the year, and was the biggest winner of this year’s Grammy Awards. In addition, when this year’s nomination list was first exposed, it was surprising that Lady GaGa’s "Art Pop" only appeared in the nomination for the best traditional pop album, but after learning that she was nominated for only one award, Lady Gaga still shared her joy on twitter. Give her a compliment for her generosity. At least she didn’t angrily announce that she wouldn’t attend the awards ceremony because her album wasn’t nominated for the album, as justin timberlake did last year.

　 　 Except for Lady GaGa, Fruit Sister was nominated for the Best Pop Album Award by Prism this year, but it was finally won by sam smith, and the Best Pop Group Award nominated by Dark Horse with Juicy J was also won by A Great Big World. However, since 2011, "Sister Fruit" has been nominated by Grammy every year, but missed the "Little Horn" award every year. She still runs with me this year, and has become the "Little Plum" Leonardo DiCaprio in music. After 7 years of professional running, it is no wonder that BiBi Zhou has to "swear" to defend his idol in Weibo, saying, "Damn it. Don’t hack my fruit sister again. If you don’t give a prize after running for seven years, you will summon the dragon next year. "

Sam smith’s fame experience

　 　 Born in London, England on May 19th, 1992, he joined the British Youth Music Troupe in 2007 and participated in "Oh! Carol "performance. In 2012, the single Latch by Sam and Decryption Brothers was released, and on May 19th, 2013, the single La La La Sam and Naughty Boys was released, reaching the top of the UK singles charts and ranking 11th in the UK singles charts. In January, 2014, Sam became the champion of BBC TV’s "Voice of the Year". Since then, like his predecessors, he has stepped towards Grammy with solid singing skills and unique style. In May 2014, Sam officially came out, admitted that he was gay, and said that his first album was about his unrequited love.

Complete winners list of 2015 Grammy Music Awards

Comprehensive award(GENERAL FIELD)

Annual album: Morning Phase》-Beck

Annual production: Stay With Me》-Sam Smith

Single of the Year: Stay with Me (Dark Child Version)–Sam Smith (sam smith)

Best newcomer: Sam Smith

Best Pop Singer: Pharrell Williams.

Best pop group: Say Something-A Great Big World with Christina Aguilera

Best Pop Instrumental Album: Bass & Mandolin-Chris Thile & Edgar Meyer

Best Pop Album: In the Lonely Hour-Sam Smith

DANCE FIELD

Best dance music recording: "Rather Be"–Clean Bandit Feat. Jess Glynne

Best Dance Music/Electronic Album: Syro-AphexTwin

Best traditional pop album: Cheek to Cheek–Tony Bennett & Lady Gaga

ROCK FIELD

Best rock musician: Jack White

Best metal performance: The Last in Line-Tenacious D.

Best rock song: ain’t it fun–paramore

Best Rock Album: Morning Phase》-BECK

Best alternative music album: St. Vincent–St. Vincent

R&B FIELD

Best R&B singer: Beyoncé

Best traditional R&B performance: Jesus Children-Robert Glasper Experimental Featuring Lalah Hathaway & Malcolm-Jamal Warner

Best R&B song: Drunk in Love–Beyond Feat. Jay Z.

Best Contemporary Urban Music Album: Girl–Pharrell Williams

Best R&B album: Love, Marriage & Divorce-Toni Braxton & Baby Face

RAP FIELD

Best rapper: "I"–Kendrick Lamar

Best rap collaboration: The Monster–Eminem Feat. Rihanna

Best rap single: "I"–Kendrick Lamar

Best rap album: The Marshall Mathers LP2–Eminem

COUNTRY FIELD

Best Country Singer: Something in the Water-Carrie Underwood

Best Country Group: Gentle on My Mind–The Band Perry

Best Country Single: I’m Not Gonna Miss You-Glen Campbell

Best Country Album: Platinum–Miranda Lambert

　　In September 2013, the Shanghai Pilot Free Trade Zone was formally established and set sail. In September 2023, the construction of China’s Pilot Free Trade Zone ushered in its 10th anniversary. Starting from Shanghai’s 28.78 square kilometers, it has been continuously expanded to about 38,000 square kilometers. In the past ten years, after six expansions, there have been 21 free trade zones and Hainan Free Trade Ports across the country, forming an innovative pattern of reform and opening up covering the east, west, north and south, and coordinating the coastal, inland and border areas, which has effectively explored and accumulated valuable experience for comprehensively deepening reform and opening up.

　　Ten years of hard work has yielded fruitful results, and it has accumulated a lot of brilliance. In the past ten years, the Pilot Free Trade Zone has launched a large number of basic and pioneering reform and opening-up measures in line with international common rules, formed many landmark and leading institutional innovations, cultivated a number of internationally competitive industrial clusters, stood at the forefront of China’s high-level opening-up, actively served major regional strategies, coordinated regional development strategies and jointly built the "Belt and Road", and achieved remarkable results.

　　In the past ten years, a total of 302 institutional innovations have gone from the China Pilot Free Trade Zone to the whole country, and more than 2,800 have been promoted and copied by various provinces, autonomous regions and municipalities, giving full play to the demonstration, leading and driving role of the Pilot Free Trade Zone, forming a good situation of sharing reform dividends and opening up the fruits to all. In 2022, the actual use of foreign capital in 21 pilot free trade zones was 222.52 billion yuan, accounting for 18.1% of the country. Among them, the actual use of foreign capital in high-tech industries was 86.34 billion yuan, a year-on-year increase of 53.2%. The total import and export volume of 21 pilot free trade zones reached 7.5 trillion yuan, up 14.5% year-on-year, accounting for 17.8% of the country; In the first half of this year, 21 pilot free trade zones accounted for 18.4% of the country’s foreign investment with a land area of less than four thousandths, and the actually used foreign capital reached 129.66 billion yuan, an increase of 8.2% year-on-year.

　　Since its establishment, China Pilot Free Trade Zone has been guided by high-level opening, and has made great efforts to explore an institutional system linked with international economic and trade rules. It has also made important breakthroughs in trade, investment, finance, and transformation of government functions, including taking the lead in implementing the national treatment plus negative list management model before foreign investment access, taking the lead in establishing a trade facilitation model centered on the "single window" of international trade, taking the lead in promoting the comprehensive opening of the service industry represented by the negative list management model of cross-border service trade, and taking the lead in implementing the "license separation". … In the past ten years, a number of firsts have been practiced and explored in the Pilot Free Trade Zone and copied to the whole country, creating a vivid model of China’s opening up and development, becoming the "vanguard" leading the country’s deepening reform in the new era, injecting stabilizers and providing new impetus for China’s economic stability and prosperity.

　　Bold trials, bold ventures and independent reforms, the fruitful results achieved in the Pilot Free Trade Zone in the past ten years come from innovation and opening up. Through a series of pioneering practices, the Pilot Free Trade Zone has continuously promoted the liberalization and facilitation of trade and investment and continued to lead the opening up. Since 2013, the negative list of foreign investment access in the Pilot Free Trade Zone has been reduced seven times, from 190 to 27 today, realizing the clearing of manufacturing items and the continuous expansion of service industry opening. Hainan Free Trade Port launched the first negative list of cross-border service trade, which realized the fundamental change of service trade management mode.

　　In addition, 21 pilot free trade zones across the country actively strengthened collaborative innovation, explored and promoted coordinated development, amplified the comprehensive effect of reform, and achieved positive results. For example, Beijing, Tianjin and Hebei Pilot Free Trade Zone established the Beijing-Tianjin-Hebei joint conference system, launched 153 items of "colleagues with the same standard" in government services, and implemented regional general office to serve the coordinated development of Beijing-Tianjin-Hebei. Shanghai, Jiangsu, Zhejiang and Anhui Pilot Free Trade Zones have established the Yangtze River Delta Pilot Free Trade Zone Alliance to create a mechanism for seeking common development, promoting innovation and sharing results, and achieved institutional innovation results in building a "single window" for international trade in the Yangtze River Delta and building an integrated oil and gas trading market. The Yellow River Basin Pilot Free Trade Zone Alliance will be established along the nine provinces of the Yellow River, and four cooperation mechanisms will be established, including "integrated construction" of social credit system, "integrated management of administrative examination and approval services", "integrated cooperation" of intellectual property protection and "integrated and smooth logistics and transportation services". Guangxi Pilot Free Trade Zone actively builds the most convenient seaport in the western region, effectively strengthens the connection with the backbone channels in southwest, northwest and central south, and serves the western development. Yunnan, Guangxi, Heilongjiang and other pilot free trade zones along the border plan to jointly promote the development and opening up along the border. The joint development of these pilot free trade zones has expanded the breadth and depth of institutional innovation, enriched the application scenarios of free trade policies, and expanded the dividend effect of free trade.It is of great significance for improving the efficiency of reform and innovation, serving to build a new development pattern, and effectively supporting the high-quality development of the free trade pilot zone.

　　Standing at a new starting point in ten years, the Pilot Free Trade Zone has ushered in new tasks. At the end of June this year, the State Council issued a document, taking the lead in conducting pilot projects in five qualified free trade pilot zones and Hainan Free Trade Port, such as Shanghai, Guangdong, Tianjin, Fujian and Beijing, connecting with international high-standard economic and trade rules, promoting institutional opening, and exploring ways for comprehensively deepening reform and opening up. The Ministry of Commerce will also work with relevant localities and departments to formulate a list of key tasks in the Pilot Free Trade Zone, clarify 164 key tasks to be independently promoted by the relevant pilot free trade zones in the next three years, further strengthen classified guidance, and promote the deepening of reform, practice and innovation in each pilot free trade zone according to local conditions.

　　Sharpen a sword for ten years and stride forward again. This year marks the tenth anniversary of the construction of China Pilot Free Trade Zone, and it is also the first year to implement the "strategy of upgrading the Pilot Free Trade Zone". On the new journey, on the basis of comprehensively summing up ten years’ construction experience, we should thoroughly implement the promotion strategy of the Pilot Free Trade Zone, carry out exploration in a wider field and at a deeper level, and strive to build a higher level pilot free trade zone. For example, we should speed up the pilot work of comprehensively docking international high-standard economic and trade rules, and further promote the institutional opening of rules, regulations, management and standards; Promote a reasonable reduction of the negative list of foreign investment in the Pilot Free Trade Zone, promote the introduction of a negative list of cross-border service trade, and lead the country to continue to expand and open up; Strengthen the overall planning and system integration of reform, thoroughly implement the upgrading strategy of the Pilot Free Trade Zone, and focus on launching a number of leading and integrated reform measures in key areas; Support their respective trade pilot zones to further deepen differentiated exploration and promote the innovative development of the whole industrial chain around key areas … … Let the seeds of institutional innovation in the Pilot Free Trade Zone take root and bear fruit nationwide, promote economic growth to rely more on innovation, and lead China’s high-quality economic development! (Yang Guangwang commentator Yu Qi)

Cctv newsVirus is a word that makes people turn pale and avoid it. However, there is such a scientist who, despite difficulties, has played a key role in successfully stopping the avian influenza epidemics such as H5N1 and H7N9 in China. She is Chen Hualan, director of the National Avian Influenza Reference Laboratory and academician of the Chinese Academy of Sciences.

The National Avian Influenza Reference Laboratory of Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, which she led, built a safety "epidemic prevention wall" by relying on a number of international leading achievements independently developed, and contributed China’s wisdom and strength to the prevention of avian influenza in many countries around the world.

Where is the initial heart?

In 1999, as a postdoctoral fellow, Chen Hualan went to the Influenza Sub-center of the Centers for Disease Control (CDC) in the United States to conduct cooperative research on avian influenza. After the exchange, the other party kindly retained him, but Chen Hualan resolutely embarked on the road of returning home.

"It doesn’t matter if the conditions are backward, we can build it slowly." Chen Hualan said that China is a big country for raising poultry. Once bird flu breaks out, it will inevitably suffer great losses if it lacks effective means. "Since the knowledge and technology I have mastered are urgently needed by the country, why don’t I come back?"

Highly pathogenic avian influenza is a class A infectious disease. Once the bird flu epidemic is found all over the world, the common way is to cull all the poultry in a certain range. Doing so not only consumes huge human and financial resources, but also brings disaster to the aquaculture industry.

"Why not seek a better solution?" Chen Hualan, who has just returned to China, boldly proposed, "It is ‘ to develop a new and efficient vaccine for prevention and control; Four or two thousand catties ’ The best choice. " The laboratory she led was designated as the "National Reference Laboratory for Avian Influenza" by the Ministry of Agriculture, responsible for the epidemic diagnosis, epidemiological monitoring and prevention and control technology research of highly pathogenic avian influenza.

At the beginning of 2004, H5 subtype highly pathogenic avian influenza raided 14 provinces in China. The National Reference Laboratory for Avian Influenza receives samples from all over the country for final identification every day. In a short time, more than 50 cases of highly pathogenic H5N1 avian influenza were diagnosed, which played a key role in controlling the epidemic in time.　

Chen Hualan led the team to speed up the pace of vaccine research and development. In more than a year, they completed the research on the new avian influenza vaccine in the laboratory. The successful development of H5N1 and H5N1 avian influenza vaccines has greatly improved China’s ability to prevent and control avian influenza and saved tens of billions of yuan for the country.

Re-war virus

In March 2013, there were cases of human infection with H7N9 avian influenza in China. The rapid spread of the virus caused a lot of panic in the country and attracted great attention from the international community.

The epidemic situation is like military intelligence, and Chen Hualan has once again started a race against the virus. She and her colleagues sent a number of teams to take samples at the first time, and then immediately conducted research and analysis.

Less than 48 hours after the first infected case was announced, Chen Hualan’s team isolated a similar virus from the samples collected in the live poultry market. According to the research results, Chen Hualan suggested that the live poultry market in infected areas should be closed immediately. After her suggestion was adopted, the number of new infections decreased rapidly.

"Although the H7N9 virus that appeared in 2013 can infect people, it is not pathogenic to poultry, and chickens do not show any clinical symptoms after infection, which makes it difficult to find the virus in time." Chen Hualan later said.

The H7N9 avian influenza virus caused a total of 5 waves of human infections, resulting in 1,567 infections, of which more than 600 people were killed. From October every year to March the following year, it is a high incidence period of human infection with H7N9 avian influenza.

Chen Hualan said: "At the thought that H7N9 avian influenza virus is threatening the lives of thousands of people, we dare not relax for a moment."

In the four Spring Festival after the emergence of H7N9 virus, Chenhualan was spent in the laboratory. But the virus is a tough opponent.

"In January 2017, we found in the monitoring that the H7N9 avian influenza virus had a key mutation, and poultry began to get sick and died in large numbers after infection." The situation that Chen Hualan is most worried about has emerged. "The mutated virus is more harmful to people, and the mortality rate can reach more than 50%."

From January to September, 2017, the "race" between team Chen Hualan and the virus entered a sprint stage: intensify on-site sample collection and pathogen monitoring nationwide, speed up virus analysis and research, formulate prevention and control measures, put forward prevention and control suggestions, speed up the process of creating efficient vaccines, and accept evaluation and testing & HELIP; … Miracle happened like this. Before the arrival of the virus epidemic season in autumn and winter of 2017, Chen Hualan team successfully launched the bivalent inactivated vaccine of recombinant avian influenza virus (H5/H7).

The popularization of the vaccine has effectively controlled the spread of H7N9 avian influenza virus in poultry and successfully blocked the infection of H7N9 avian influenza virus in people.

be as usual

Behind the first-class scientific research is the unimaginable contribution of ordinary people. Team Chen Hualan conducts large-scale avian influenza virus monitoring twice a year, and members go to farms and live poultry markets across the country to take samples from live poultry and bring them back for analysis. When sampling, researchers should use swabs to take samples from the deep throat and cloaca of chickens respectively. In 2017 alone, the team members sampled 53,000 copies. After returning to the laboratory, they must isolate the virus as soon as possible and do further analysis and research.

In addition to epidemic diagnosis and vaccine research, Chen Hualan also led the team to strengthen the active surveillance of avian influenza epidemiology in China and explore the biological characteristics of the virus. By giving full play to the individual strengths of team members, a full chain and systematic influenza research layout has been formed. At the same time, it shoulders the responsibility of providing scientific reference for the prevention and control of bird flu epidemic and early warning of human influenza.

In 2013, Chen Hualan was selected as one of the top ten scientific figures in Nature, and Nature called her "the one fighting in the front line ‘ Influenza detective ’ " . In 2016, Chen Hualan won the "World Outstanding Female Scientist Achievement Award" awarded by UNESCO.

Even though Chen Hualan has stood in the leading position in the world, he and his team are always in a state of "preparing for war". Chen Hualan said: "Avian influenza virus can infect not only poultry, but also migratory birds. Migratory birds who migrate across borders are very free, and they don’t need to fly to any country ‘ Passport ’ . If they carry the virus, an epidemic may occur as soon as they come into contact with local poultry. We must always be vigilant and respond to emerging epidemics at any time. "

Now, the word "avian influenza" has quietly faded out of the sight of ordinary people, while Chen Hualan remains vigilant. "The highly pathogenic avian influenza virus has evolved rapidly, and we can’t relax at all". Some people ask, is it worthwhile to give up many pleasures in life for work? Chen Hualan replied slowly: "Is it more fun and worthwhile for researchers engaged in the prevention and control of infectious diseases to nip the highly dangerous bird flu epidemic in the bud?" (Text/Kan Chunyu)

Special feature of 1905 film network To say that the most "beautiful" award in every Oscar is not the best film or the best actress!

　

It’s the "Best Fashion Design" unit! (Refutation not accepted)

Winner of the Best Fashion Design Award in 2017 — —　

Although it is often neglected as a technical award, it is undoubtedly an important part of the art of movie dreaming. Without clothes tailored for the role, even amazing performances will be eclipsed.

Winner of the Best Fashion Design Award in 2016 — —

The film costume design should always balance the relationship between the theme of the film and the exquisite clothes, which should not only make people unforgettable, but also avoid usurping the host’s role and test the designer’s ingenuity.

　

Award-winning films in the past three years — — Fantastic Beasts and Where to Find Them, Mad Max: Fury Road and others all show this point.

Award-winning film of Best Fashion Design Award in 2015 — — The Grand Budapest Hotel.

Let’s take a look at the five finalists of this year’s Oscar’s "Best Fashion Design" — — 、、、、。

　

This year’s finalists have featured vintage cards, which can be said to have their own advantages and strong hands. What Xiao Dianjun is going to introduce to you today is also one of the seed players. It is the Phantom Sewer starring Daniel Day Lewis.

The Phantom Sewing Craftsman is also translated into Phantom of the Dress. As soon as you hear the name, you will know that it has something to do with "fashion".

　

Reynolds Woodcock, the hero of the film, was also a leading figure in the fashion circle in the 1950s.

　

He and his sister Cyril jointly control the family brand, and the European royal family, ladies and celebrities from all walks of life are their customers. In terms of feelings, Woodcock, a talented man, is a committed celibate, letting his lover come and go around and never being moved.

　

However, the appearance of a young woman named Elma broke his orderly life, aroused his long-cherished enthusiasm and desire, and finally became his determined muse and lifelong companion.

　

In the film, "poisonous mushroom" is a "panacea" to maintain their feelings. Elma used poisonous mushrooms to show the weak side of the powerful Reynolds, and Reynolds also acquiesced in the poisoning behavior and enjoyed the careful company of his lover at his bedside when he dropped his guard.

　

This kind of "sadomasochism", like drinking poison to quench thirst, wandered on the edge of morality and discipline, and it caused a lot of controversy and discussion after its release.

　

However, the theme of the film is not the focus of Xiao Dianjun’s discussion. After all, there are different opinions on the concept of love. But regardless of the theme, the film’s powerful creative team and beautiful and retro pictures deserve its six Oscar nominations.

　

Director and screenwriter paul thomas anderson (PTA) won the Best Director Awards in Berlin, Cannes and Venice. At the age of 42, he became the first director to win a Grand Slam in three major international film festivals in Europe.

The leading actor is Daniel Day Lewis, who won three Oscars for best actor, and he will compete for the title of best actor again with this "mountain-closing work".

[Character prototype]

Paul thomas anderson didn’t explicitly reveal the prototype of Woodcock, but many sharp-eyed fans and fashion fans pointed out that the male protagonist is very much like the combination of cristobal Valencia, Charles James and Karl Lagerfeld, the founders of Balenciaga.

Cristobal Balenciaga

　

They are all typical "genius is on the left, madman is on the right" figures, who are brilliant in their own best fashion field, but they are often paranoid and eccentric in mortal life.

　

In order to be infinitely close to people, Daniel Day Lewis spent a year studying fashion design and sewing skills under Mark Harper, the royal designer of new york Ballet.

　

The core task of the training course is to restore a classic dress of the famous designer cristobal Valencia stitch by stitch.

　

Designed by cristobal Valencia in 1962.

　

It was not until this amazing evening dress was completely reproduced that Lewis agreed to officially start shooting. The three-time Oscar winner’s professionalism was well-deserved.

　　

[Royal Designer]

To say that PTA, a fashion layman, is the biggest contributor to the "dream come true", it is naturally the fashion designer of the film — — Mark Bridges.

Designer Mark Bridges.　

He is the royal designer of PTA, and they have cooperated in many works, such as,, and so on. Bridges also won the Best Costume Design Golden statuette in the 84th Oscar for his films.

Stills of The Artist

　

In order to restore the classic charm of British clothing in 1950s, Briggs was allowed to enter the famous V&A Museum in London and get a close look at the masterpieces in the museum, including Givenchy, Ba Erman, Balmain, the Balenciaga family, Charles Fredericksworth, the father of Gao Ding and so on.

While drawing inspiration from the master, Bridges also needs to combine the movie plot and the characters’ characteristics to tailor-made clothes with both artistic aesthetics and focus plane feeling.

　　　

Special clothing exhibition held by V&A Museum in London

Bridges’ team has designed and produced more than 50 original works for this film, including wedding dresses, evening dresses and everyday clothes. Among them, there is a set of consistent and unified spring Collection. It can be said that in order to make a movie, the whole process of a fashion show from design to display was really repeated.

　

Next Page: Analysis of Classical Modeling in the Play

　　When the summer heat hits the midsection, the weather is so hot that there is nowhere to hide. In the hot sauna days, eating crayfish and drinking a glass of cold beer, not to mention how pleasant it is, but recently people dare not enjoy it so much because of some rumors.

　　The "classification map of crayfish after death" transmitted by the internet has made many people ask their souls: "Delicious and attractive crayfish, what kind of garbage are you?" After that, the takeaway order of crayfish was silently cancelled; And the saying that "you can’t drink cold drinks in dog days, you have to drink hot water to force the cold" has made some people put down the bottles of iced beer.

　　Are we destined to have a tasteless summer? The reporter of Science and Technology Daily interviewed relevant experts, shattered the rumors one by one, and gave you a cool summer as usual.

　　Proverbs 1

　　Lobster meat is wet garbage and lobster head is dry garbage.

　　It’s the season to eat crayfish again, but since many places in the country have entered the "mandatory era" of garbage sorting, and a "classification map of crayfish after death" has been posted on the Internet, crayfish lovers are no longer afraid to eat without scruple. According to the classification map, the whole crayfish is wet garbage, and the yellow lobster head is dry garbage; Lobster meat and lobster yellow are wet garbage, and lobster shells are dry garbage.

　　Many netizens said that eating crayfish is refreshing for a while, but after eating it, the garbage classification is heartbroken, so don’t eat it. In fact, throwing a crayfish is not as complicated as the picture. This picture is wrong.

　　Shanghai Waste Management Office responded through WeChat WeChat official account that crayfish, lobster shell, lobster head, lobster yellow and lobster meat all belong to wet garbage.

　　In April 2019, the "Guidelines for the Classification of Domestic Waste in Shanghai" also clearly pointed out that aquatic products and their processed foods (fish, fish scales, shrimp, shrimp shells and squid) are all wet wastes.

　　"It is not difficult to distinguish between dry and wet garbage. Dry garbage refers to garbage that can be burned, and wet garbage is garbage that is perishable, easy to crush and compostable. It is a bit taken for granted that crayfish shells are classified as dry garbage in the above classification map. In fact, it is relatively easy to rot and crush, so it belongs to wet garbage. " Yi Zhu, an associate professor at the College of Food Science and Nutritional Engineering of China Agricultural University, explained.

　　If you still can’t tell what kind of garbage is on your hand, remember the official recommendation of Shanghai for garbage classification: recyclable materials — — Glass, gold, plastic, paper and clothing; Harmful waste remembers the formula — — Medicine (oil) (electric light); The principle of wet garbage recording — — Perishable and easy to crush; The rest is dry garbage.

　　Proverbs 2

　　You can’t eat cold drinks in dog days, but drink hot water to force the cold.

　　Cicadas sound, summer is strong, and the heat in the dog days seems to be dependent on cold drinks. However, a recent health tip circulating on the Internet pointed out that all iced drinks should be rejected in dog days, otherwise the cold will invade and cannot be discharged. Insist on drinking hot water in the dog days, so as to force out the cold that goes deep into the bone marrow. This is called treating winter diseases in summer.

　　At first glance, there is some truth, but is this really the case?

　　The doctor reminded that the statement that "don’t drink iced drinks and eat iced food" on the dog days is too absolute. In fact, for most people, there is no problem of completely avoiding cold drinks, and eating some cold drinks properly will not cause harm to the body.

　　Li Fangling, chief physician of Chinese Medicine Department of Beijing Geriatric Hospital, told the media: "In summer, the temperature is too high for people to stand. At this time, eating moderate cold drinks can relieve the heat and make people feel comfortable."

　　However, Yi Zhu also pointed out that drinking ice water when it is very hot will cause rapid contraction of blood vessels, and the oxygen consumption of heart, brain and other organs will increase, which will cause blood pressure fluctuation, especially for the elderly with cardiovascular and cerebrovascular diseases. For young people, eating ice cream and drinking iced drinks in dog days may lead to sudden headaches. And eating too much cold food can also cause gastrointestinal cramps and diarrhea. "Therefore, we do not encourage unrestrained use of cold drinks to relieve the heat in the dog days." She said.

　　However, the theory that drinking hot water can force out the cold is not recorded in Chinese medicine. "Although it is not advisable to be greedy and cold in the dog days, it is a bit exaggerated and there is no scientific basis to force out the cold that has penetrated into the bone marrow for many years by drinking hot water in the dog days. The way to maintain health advocated by Chinese medicine lies in persistence all year round, and improving physical fitness is not a one-off event. " In Yi Zhu’s view, drinking hot water in summer is generally suitable for people who need to sweat because of a cold, but drinking overheated water will also cause damage to the digestive tract mucosa, and it is advisable to drink warm water in small quantities for many times in hot weather.

　　Proverbs 3

　　Famous biologists have developed cold-resistant mosquitoes.

　　The most annoying thing in summer is mosquitoes besides the high temperature. People are afraid to avoid this annoying creature, but a screenshot of a recent report on the emergence of cold-resistant mosquitoes surprised netizens. The report said: Professor Li, a famous biologist in China, has worked hard for more than 30 years and successfully cultivated cold-resistant mosquitoes. This mosquito can also come out to bite people in winter, which fills the gap that there are no mosquitoes in winter in China … … The source of the article also marked the authoritative media, but the description of the article made people feel incredible. Some netizens joked: "We don’t need mosquitoes in winter, so it’s better not to fill this gap."

　　According to the reporter’s review, the authoritative media marked at the source of the article has never reported it at all. This is actually an old story full of plastic sense. This paragraph first appeared in 2014, and the version has been iterative since then.

　　In fact, there are many loopholes in the above rumors that can be seen at a glance. For example, it is impossible for authoritative media reports to have the nonstandard title of "Professor Li, a famous biologist in China". Moreover, from the scientific common sense, it is not uncommon for mosquitoes to appear in winter, and experts have already made popular science. Mosquitoes are at the temperature of 15℃— The vitality is still very strong at 16℃. Even in winter, if the indoor temperature is high, it can wake up the dormant mosquitoes.

　　Proverbs 4

　　Common genes in genetically modified crops appear in China.

　　Recently, many WeChat groups are spreading an article — — British Research: Genes common in genetically modified crops have appeared in China, please be careful of the next generation. Accordingly, some WeChat WeChat official account articles with 100,000 hits vowed to write: "This is another proof of the harm of genetically modified weapons to Chinese."

　　Is this really the case? That’s not true. This is actually a patchwork of fishing articles and rumors about genetically modified foods, which is an advertisement for the platform of non-genetically modified food grocery stores.

　　According to this article, an article published in the British academic journal Shelley Genetics Newsletter has attracted the attention of domestic academic circles. Professor Victor Stein, a geneticist from the German Tesrosa Medical Center, is currently conducting an international genomics research project in China … …

　　Lin Min, a researcher at the Institute of Biotechnology, Chinese Academy of Agricultural Sciences, said that there was no British academic journal Shelley Genetics Newsletter, and the so-called Tesrosa Medical Center was also invented.

　　The article also said: "Almost all genetically modified foods contain SCoAL gene." "SCoAL will synthesize succinic acid in the human body, which is highly acidic and corrosive and may cause blindness when it enters the eyes."

　　However, Jiang Tao, a senior engineer at the Biology Research Center of the Institute of Genetics and Development, Chinese Academy of Sciences, pointed out that the gene name SCoAL was concocted.

　　"And succinic acid, also known as succinic acid. Nutritional supplements containing succinic acid are food additives and dietary supplements, which are approved as edible safety by the US Food and Drug Administration. All living things produce succinic acid. " Lin Min said.

Original biological world biological world

Written by Cong Wang

Edit Wang Duoyu

Typesetting and writing in water

Epstein-Barr virus (EBV) is one of the most common viruses in the world. EBV is easily transmitted through body fluids (mainly saliva), such as kissing and sharing drinks or tableware. According to statistics, 90%-95% people around the world have been infected, usually in childhood.

EBV infection can cause infectious mononucleosis or similar diseases, but it usually has no symptoms. Most EBV infection symptoms are mild and will disappear, but these viruses will persist and lurk in the body, and will be reactivated. In recent years, some studies have shown that long-term latent EBV virus is related to some chronic inflammation and various cancers, and some studies have found that EBV may be the pathogenic factor of multiple sclerosis (MS).

On April 12th, 2023, the team of Professor Don Cleveland from the University of California, San Diego published a research paper entitled Chromosomal Fragile Site Breakage by EBV-Encoded EBNA 1 at clustered repeats in Nature.

This study describes for the first time how Epstein-Barr virus (EBV) uses the fragile sites in the human genome to cause chromosome breakage, cause cancer, and reduce the human body’s ability to suppress cancer.

There are fragile sites in everyone’s genome, and these specific chromosome regions are more prone to mutation, breakage or deletion during DNA replication. These changes may be related to disorders and diseases, which may lead to genetic diseases and cancer.

Professor Don Cleveland

Professor Don Cleveland, the correspondent of the paper, said that this study revealed how EBV induced the breakage of human chromosome 11 and caused a series of genomic instability, which may activate the oncogene that causes leukemia and inactivate the main tumor suppressor gene. This also proves for the first time how to selectively induce the breakage of fragile DNA sites.

In this latest study, the research team focused on EBNA1 protein, a viral protein that persists in human cells infected with EBV. Previous studies have shown that EBNA1 will bind to a specific genome sequence at the beginning of EBV genome replication. This study found that EBNA1 also combined with a cluster of EBV-like sequences at a fragile site of human chromosome 11, where the increase of protein abundance would lead to chromosome breakage.

Previous studies have shown that EBNA1 can inhibit p53 gene, and p53, known as the "genome guardian", plays a key role in controlling cell division and cell death. Under normal circumstances, p53 can inhibit the occurrence and development of tumors, while mutant p53 is related to the growth of cancer cells.

The research team also examined the genome-wide sequencing data of 2,439 cancers of 38 cancer types from the genome-wide pan-cancer analysis project. They found that tumors with EBV infection showed higher levels of chromosome 11 abnormalities, especially head and neck cancer cases.

Julia Su Zhou Li

Julia Su Zhou Li, the first author of the paper and a postdoctoral fellow, said that for a virus that is ubiquitous and harmless to most people, it is still an ongoing effort to identify high-risk groups susceptible to latent infection-related diseases. This study shows that the susceptibility to EBNA1-induced chromosome 11 breakage depends on the control of the level of EBNA1 protein produced in latent infection and the genetic variation of the number of EBV-like sequences on chromosome 11 in each individual. Looking ahead, this discovery paves the way for screening the risk factors for the development of diseases related to EBV infection. In addition, blocking the combination of EBNA1 and EBV-like sequence on chromosome 11 can be used to prevent the development of EBV-related diseases.

Paper link:

https://www.nature.com/articles/s41586-023-05923-x

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