Original Bajiuling Wu Xiaobo Channel

It may be difficult for pharmaceutical companies to embark on the road of OEM, but it is not a long-term solution after all.

Text/Ba Jiuling (WeChat WeChat official account: Wu Xiaobo Channel)

01

These things you bought online are probably branded products.

Have you bought scar cream, hair tonic, warm palace stickers, diet pills and other health care products online? If these products come from well-known pharmaceutical companies such as Renhe, Tongrentang and Xiuzheng, will you have more trust, even if its price is higher than similar products, will you pay for them?

But in fact, the products you bought are probably not from the pharmaceutical companies’ own factories, but are OEM products.

For example, Tmall’s "Medicine Capital Renhe Flagship Store" has a monthly sales of 10,000+and more than 7,000 comments. According to the product details page, this product is from Renhe Pharmaceutical, but it does not appear in the product list of Renhe Pharmaceutical official website.

According to the approval number of this product "G20180064", minibus found the registration information of this product in official website of the Food and Drug Administration, which showed that the manufacturer was "Guangzhou Aifuyi Biotechnology Co., Ltd.", and the last remark information also stated that its actual manufacturer was: Guangzhou Tengyu Cosmetics Co., Ltd.

Enterprise investigation shows that Guangzhou Aifuyi and Guangzhou Tengyu have no equity relationship with Renhe Pharmaceutical. This is a typical OEM product.

On the platform of investor interaction, many investors have raised a similar topic to Renhe Pharmaceutical, such as "What is the relationship between anti-alopecia lotion and Renhe Pharmaceutical", and they are concerned about the actual relationship between such branded products and Renhe Pharmaceutical.

02

The OEM model has spread to the medical field.

Today, the OEM model has been very popular in all walks of life. The most typical is the Antarctic people. Open a shopping platform, there will be many shops related to Antarctic people, and the products are countless, from shoes and clothing to bedding, from electric irons to gas stoves.

Antarctic people were originally a company that started from making underwear. Since 2008, Antarctic people have closed all the production lines of their own factories, and since then they have changed from "selling products" to "brand authorization", earning a lot of money. In 2019, Antarctic people earned 1.3 billion yuan through brand authorization. In 2020, the gross profit margin of Antarctic OEM service will reach 93.26%.

In recent years, the OEM model has spread to the medical and health care industries. Renhe, Tongrentang, Xiuzheng, Sunflower and many other well-known pharmaceutical companies increase their income through brand authorization.

Taking Renhe Pharmaceutical as an example, according to its 2020 annual report, the company achieved a total operating income of 4.106 billion yuan. The company’s products are divided into self-owned products and OEM products. From the perspective of income, self-owned products and OEM products basically account for half.

The OEM model supports half of the revenue of an old pharmaceutical company, which is enough to prove the dependence of well-known pharmaceutical companies on the OEM model.

Compared with R&D, OEM is obviously an easier shortcut. Accustomed to taking shortcuts, they are even more reluctant to take the difficult but correct path.

According to the third quarterly report of 2021 disclosed by Renhe Pharmaceutical, in the first three quarters, the company’s R&D expenses were 42.76 million yuan, and its revenue was about 3.659 billion yuan. The proportion of R&D expenses in revenue was only 1.1%. According to the annual report of Renhe Pharmaceutical for nearly 4 years, its annual sales expenses are 14-26 times as much as R&D expenses. Renhe’s characteristics of "emphasizing marketing and neglecting research and development" are often criticized by the outside world.

However, this is not the problem of Renhe. According to the survey report of the consulting industry in China, the R&D expenditure of large international pharmaceutical companies generally accounts for 15%-20% of the total sales, while the R&D investment of domestic pharmaceutical companies accounts for only 2%-3% of the sales revenue on average.

03

Want to win by branding? I’m afraid not.

Although the road to OEM is easy, it is not once and for all.

Just like Antarctic people, they thought they could "win" by brand authorization, but these two years have not been easy.

Since July last year, the share price of Antarctic e-commerce has dropped from the highest point of 24.41 yuan to around 7 yuan today, and its market value has evaporated by nearly 40 billion yuan. According to its 2021 semi-annual report, in the first half of 2021, the net profit of Antarctic e-commerce attributable to shareholders of listed companies was 246 million yuan, down 42.85% year-on-year.

The OEM model is like a double-edged sword, which not only contributes a lot of profit to the enterprise, but also brings various negative problems to the brand, such as product quality, word of mouth and even false propaganda.

There are many complaints about branded products of pharmaceutical companies on the websites of Black Cat Complaint and 315 Consumer Protection Complaint. Most of the complaints revolve around "invalid products", "fake goods", "no refund" and "false propaganda".

Minibus searched Pinduoduo for a wound care ointment. According to the industry details page, this product comes from a national brand-Amendment. Its function is "scar removal without leaving any trace", and it has been put on record by the Drug Administration, with good safety effect.

The actual manufacturer of this ointment is "Jiangxi Bingshuangjiefu Industrial Co., Ltd.", which has no equity relationship with Xiuzheng Pharmaceutical and belongs to OEM products.

According to the record number "Ganzhang Machinery Equipment No.20190083" provided by it, the minibus made an inquiry on the website of National Medical Products Administration, and the record information showed: "This product is ointment. The contained components have no pharmacological effects. The ingredients contained cannot be absorbed by the human body. Non-sterile. "

The "intended use" item is blank.

The minibus inquired about other brands of scar-removing ointment of the same type, and the column of "expected use" said "suitable for inhibiting and relieving hyperplastic scars caused by burns, trauma, surgery and other reasons".

In other words, this ointment probably has no scar removal effect. If so, then this product has the problem of false propaganda.

04

How can you post it? Who is responsible for the problem?

Who should be responsible for the quality problems of OEM products? The minibus consulted Chang Dongyue, the director of Shanghai Law and Craftsman Law Firm, and he thought that once the branded goods had quality problems, the brand supplier was the direct responsible person, and the processor was also liable under normal circumstances. Moreover, this is based on the quality problems of legally produced products, and it is necessary to bear civil liability.

However, more and more enterprises don’t talk about "martial arts", and many enterprises alienate OEM into pure lending brands, which is very problematic without any quality supervision on quality. In this case, if the illegal production leads to extremely bad social consequences, the brand and producer of OEM products not only need to bear civil liability, but also need to bear administrative responsibility and even criminal responsibility.

Chang Dongyue also said that the safety of food and drugs is related to people’s right to health and even life. Quality problems may cause irreversible damage to the body, and no matter how strict the quality supervision of food and drugs is. Regrettably, although China’s Food Safety Law, Drug Administration Law and Product Quality Law all stipulate product quality responsibility, the sanctions for violating food and drug safety are still too light, so that the food and drug field in China is still not safe enough. In this regard, the United States and Japan’s practice of using heavy codes to control food and drug safety is quite good and worth learning.

Relying on legal sanctions is the last step. As an enterprise, it should be its duty to abide by the rules. How can have no martial ethics, a post it?

According to Shi Lichen, the founder and strategic marketing expert of Beijing Dingchen Management Consulting Co., Ltd., OEM is not illegal, and the key is how to continue to control quality while authorizing. Whether you are OEM or OEM, consumers only know that they are buying your brand. Pharmaceutical companies should pay special attention to quality, otherwise, as the authorized products become more and more miscellaneous, the quality can not be controlled, and finally the reputation of the main business will be affected, which will not be worth the candle.

05

Difficulties and new ways for pharmaceutical companies

The advantages and disadvantages of OEM mode are very clear, and it can easily make money, but it is difficult to control the quality and the brand is easily damaged. The reason is very simple. The question is, those old pharmaceutical companies that have spent a hundred years settling down should have cherished their feathers. Why are they addicted to OEM?

Shi Lichen explained the reasons behind it: in recent years, the competition in the pharmaceutical industry has been fierce, and the operating pressure of pharmaceutical companies has increased. The old pharmaceutical companies have to find a way out. First, solve the fundamental problems and increase investment in research and development; Second, based on its own cost advantage, to achieve economies of scale. But these two roads are not easy to walk.

"In contrast, the OEM business has almost no cost and high net profit, so those pharmaceutical companies with brand awareness and strong premium ability naturally embarked on this road."

From this point of view, it is difficult for the old pharmaceutical companies to embark on the road of OEM, but this is not a long-term solution after all. Is it possible to open up a new road?

There is indeed a new road that has emerged-the field of cross-border beauty cosmetics and daily chemicals for pharmaceutical companies.

With the strong growth of functional skin care products, pharmaceutical companies such as Renhe, Pien Tze Huang, Tongrentang, Ma Yinglong, Yunnan Baiyao, Panlong Yunhai, Dong ‘e Ejiao and Xiuzheng Pharmaceutical have all set foot in the cosmetic and daily chemical industry.

Pien Tze Huang disclosed the 2020 financial report, and the company achieved operating income of 6.511 billion yuan, a year-on-year increase of 13.78%; The net profit was 1.672 billion yuan, a year-on-year increase of 21.62%. Behind the growth, the cosmetics sector contributed a bit. Its holding subsidiary Fujian Pien Tze Huang Cosmetics Co., Ltd. achieved revenue of 611 million yuan, up 42.01% year-on-year, and net profit of 114 million yuan, up 41.23% year-on-year.

In July this year, Renhe Pharmaceutical announced that it planned to acquire 80% equity of seven cosmetics companies for 719 million yuan. One of them, Shenzhen Miura Natural Cosmetics, has been independently producing Renhe brand cosmetics, and some of the products distributed by the other six target companies come from this company.

In this regard, Shi Lichen analyzed that there is a huge Japanese industry called cosmeceuticals, which is not available in China, but we can make some functional cosmetics. Well-known pharmaceutical companies have natural advantages in making cosmetics across borders. For example, if brands can support the premium of products, they can get higher profit points. In addition, pharmaceutical companies themselves already have strong management teams, marketing teams and capital levels, which are not available to ordinary enterprises.

"The difference is nothing more than that some pharmaceutical companies, such as Renhe, have cultivated Renhe brand cosmetics related products through OEM before, and some products already have a certain market share, brand awareness and user base. At this time, it is logical to conduct mergers and acquisitions. Some pharmaceutical companies have had less involvement in this area before, so they may have to do it from scratch. "

In this way, pharmaceutical companies cross-border to make beauty cosmetics and daily chemical products. Originally, they just wanted to be a sideline through brand authorization. In the future, they may become one of their main businesses and gain new profit growth points by creating explosive IP products.

Author | Li Mengqing | Duty Editor | Zhang Wenlong

Editor | He Mengfei | Editor | Zheng Yuanmei | Tuyuan | vision china

Original title: "Old pharmaceutical companies learn from online celebrity brand. Have you ever bought such branded products? 》

Read the original text

　　The General Administration of Customs announced today (6th) that in the first half of this year, the national customs suspended the export to China of 144 food enterprises that suffered from the COVID-19 outbreak, and at the same time, returned or destroyed the risky imported food to prevent unqualified food from entering the country.

　　According to customs statistics, this year 1-mdash; In June, the national customs conducted a total of 1,098,700 samples of imported cold-chain food, animal and plant products for COVID-19 virus detection; A total of 27,114,400 imported cold-chain foods were supervised for preventive disinfection at ports.

　　Kong Xiaobang, Director of General Department of Import and Export Food Safety Bureau of General Administration of Customs:Since the outbreak of the epidemic, as of July 1st this year, we have randomly selected 296 overseas food enterprises in 60 countries and regions through remote video, and suspended the export of 144 overseas food enterprises with COVID-19 outbreak employees to China, effectively ensuring the safety of imported food in China.

　　At the same time, the customs strictly returns or destroys the imported food with risks to prevent unqualified food from entering the country. 1-mdash this year; In June, the national customs detected 1,070 batches of food that were not allowed to enter the country due to unqualified safety and hygiene items in port supervision, and all of them were returned or destroyed.

　　In addition, the customs has also enhanced the understanding of the safety of imported and exported food in various ways. Today, in addition to Hangzhou, other customs across the country have also launched the "National Food Safety Publicity Week" in 2021, with a variety of publicity, display and Q&A activities to publicize and interpret imported food safety and port food hygiene and safety laws and regulations to import and export enterprises and consumers, and strictly supervise imported food.

　　Zang Juan, Inspection Section of Qianjiang Customs Office in Yuhang, Hangzhou Customs:Consumers can first check whether the food is labeled or labeled in Chinese, and whether the product name, country of origin (region), ingredient list, production date and other information are marked on the label.

　　If there is no such Chinese label on imported food sold in the market, it can be regarded as an informal channel. Secondly, you can also ask the sellers for the Inspection and Quarantine Certificate of Entry Goods issued by the Customs or log on to the website of the General Administration of Customs to check whether the imported food meets the access requirements, so as to ensure that the imported food you buy is imported in compliance.

I. Basic information of the project

Project number: SJZGK20250234

Project Name: Dog Management Security Service of Shijiazhuang Public Security Bureau

Budget amount: 857200

Maximum price limit (if any): 857200

Procurement demand: This project mainly includes: the dog certification service center of the public security police detachment of Shijiazhuang Public Security Bureau and the dog detention center need to hire 18 security guards to provide security services, assist the police to investigate and deal with large dogs and fierce dogs that are illegally kept, take in stray dogs, carry out civilized dog-raising publicity activities, and conduct street inspections on uncivilized dog-raising behaviors.

Duration of contract performance: 12 months.

This project does not accept consortium bidding.

Second, the applicant’s qualification requirements:

1. Meet the provisions of Article 22 of the Government Procurement Law of People’s Republic of China (PRC);

2. Qualification requirements for implementing the government procurement policy: 1. This project is specially designed for small and medium-sized enterprises to purchase; 2 Other qualification requirements for implementing government procurement policies (if any): Inquire through channels such as Credit China (https://www.creditchina.gov.cn), China Government Procurement Network (http://www.ccgp.gov.cn) and China Executive Information Open Network (http://zxgk.court.gov.cn). Not included in the list of parties involved in major tax violation cases, the list of records of serious illegal and untrustworthy behaviors of government procurement, and the list of untrustworthy executors published by the Supreme People’s Court (subject to the results of the purchaser’s inquiry after the bidding deadline).

3. Specific qualification requirements for this project: None.

Third, obtain the tender documents

Time: from April 29th, 2025 to May 8th, 2025, from 00: 00 am to 12: 00 am and from 12: 00 pm to 23:59:59 pm (Beijing time, except legal holidays).

Location: Shijiazhuang public resources trading platform download, website: http://110.249.147.67/G2/, bidders should pay attention to whether the project has any correction announcement in time.

Mode: Other

Price: 0

IV. Deadline for submission of bid documents, time and place of bid opening

09: 30 May 22, 2025 (Beijing time)

Venue: Shijiazhuang Public Resource Trading Platform, website: http://110.249.147.67/G2/.

V. Announcement Period

5 working days from the date of this announcement.

VI. Other Supplementary Matters

According to the "Hebei Provincial Department of Finance Hebei Provincial Government Service Management Office on the issuance of<政府采购公开招标项目全面实行“双盲”评审实施方案>According to the relevant requirements of the Notice, this project adopts a "double-blind" review. The supplier shall make the commercial bid and the technical bid separately according to the requirements of the tender documents, and the bid evaluation committee shall review the commercial bid and the technical bid according to the requirements. Obtain bidding (procurement) documents: log on to Shijiazhuang Public Resources Trading Platform (http://110.249.147.67/G2/) and download the bidding (procurement) documents (*.HBZ). 1. Before obtaining the documents, the supplier shall register (telephone number 0311-89668589) according to the "Government Procurement Supplier Operation Manual 20210701", and consult the CA certificate business: the national public resource trading platform (Hebei Province) shall handle the CA certificate business in http://publicservice.hebpr.gov.cn:8181/. Download Path: Business Guide of Shijiazhuang Public Resource Trading Network (http://110.249.147.67/G2/)-Download Center 2. After obtaining the documents, the supplier should download the [Government Procurement] (Bidding) Document Preparation Tool 7.8.2005.2330, the "CA Certificate Driver Installation Program Download Instructions" and the "Government Procurement Response Document Preparation Tool Operation Instructions" before installing these tools. Download path: Shijiazhuang public resource trading network(http://110.249.147.67/G2/) "Business Guide"-"Download Center" Technical Tel: 0311-89868327 3. When opening bids, the supplier shall decrypt the electronic bidding (response) documents with the CA digital certificate. 4. This project is subject to "double blind" evaluation, that is, the evaluation experts are randomly selected from the provincial expert database to realize "blind selection" of the evaluation experts; The commercial bid and technical bid of bidding (response) documents are made separately, and the evaluation committee adopts the open bid evaluation and the hidden bid evaluation for the commercial bid as required, so as to realize "blind evaluation" in the evaluation process. Due to the market subject’s own reasons, the consequences caused by the failure to obtain and submit documents within the effective time shall be borne by the market subject itself.

7. For inquiries about this tender, please contact in the following ways.

1. Purchaser information

Name: Shijiazhuang Public Security Bureau

Address: No.66 Yuannan Road, Shijiazhuang

Contact information: 0311-89667000

2. Information of purchasing agency (if any)

Name: Shijiazhuang Public Resource Trading Center

Address: Xingshi Square, No.87 Shengli South Street, qiaoxi district, Shijiazhuang.

Contact: 0311-89665583

3. Contact information of the project

Project Contact: Gu Yi

Tel: 0311-89667000

VIII. Annexes

　　The reference news network reported on July 24. Spain’s "Fun" monthly magazine published an article in May, saying that smiling is healthier. Why do some funny things make some people laugh while others are indifferent? "I think humor is a way of looking at life and an immune mechanism at the same time," said Javier Cansado, a Spanish comedian. "I always think my children are funny, but they are not humorous. I may be able to teach them how to taste wine, but a sense of humor is innate. "

　　According to the article, laughter is a widely studied behavior in the scientific community for decades, and humor shows more about what we think and feel about our relationship with others. Humor is an emotion, so it is difficult to measure.

　　Capture the funny dance of neurons

　　With the help of advanced neuroimaging technology, we know that humor originates from the misidentification area in the center of the brain, which is located directly above the corpus callosum connecting the left and right hemispheres. From this position, you can "supervise" all other areas of the brain that perform their duties.

　　When we are listening to a joke, the sound waves emitted by words will be transmitted to the brain through electrical pulses. How can I hide an elephant in a cherry tree? Faced with such a brain teaser, the left hemisphere will immediately start sorting out information and try to guess the logical ending. At the same time, a small active area in the right hemisphere will help us imagine this narrative from a very absurd angle. In addition, we also need the help of a brain region related to processing language and memory in a short time. When the answer "dye its hooves red" appeared, the surprise broke our expectations. The error recognition area is responsible for synchronizing the logical and illogical parts of the narrative. Once an error is detected, the brain will get compensation by releasing dopamine called "happiness hormone", which will trigger laughter. "A sense of humor requires a flexible brain, because the processes of understanding a joke, finding the interesting part and laughing are highly synchronized." Natalia Lopez Moratalla, an expert in biochemistry at Navarra University, pointed out.

　　According to the article, humor can stimulate positive emotions, but it may not necessarily eliminate negative emotions. In fact, in a sad atmosphere such as a funeral, sometimes we can’t help laughing. Although it seems very rude, it is just a way to deal with existing emotions. Humor can even help us get closer to others in tense moments.

　　The same effect as doing exercise.

　　Lisa Rosenberg, a researcher at Rush University Medical Center in Chicago, analyzed how humor can help in jobs that require quick and accurate decisions. "Joking often can relax our brains and increase our objectivity in the face of great pressure." Rosenberg said. Humor and its most common expression, laughter, are not only very useful to us as a psychological defense mechanism, but also bring benefits to our bodies. First of all, laughter is an aerobic exercise, and the exercise effect achieved by laughing for 100 times is equivalent to riding a bicycle for 15 minutes. In addition, the health of laughter lies in "accelerating the heart rate and supplying oxygen to the brain", Moratalla said, "People with a sense of humor have healthier immune mechanisms, the probability of myocardial infarction will be reduced by about 40%, and the average life expectancy will be increased by four and a half years".

　　According to the article, many scientists suggest laughing for at least 15 minutes every day, because laughter may even have the effect of "painkiller". A scientific team at Allegheny College in Pennsylvania, USA, found in the experiment that if people happened to watch a drama before being shocked, the pain they felt would be less intense. The reason is that laughter can promote the production of endorphins, which are considered to be the natural "morphine" secreted by the body.

　　"Obviously, laughter and humor can’t cure the pain by themselves, but they can bring benefits to diseases with low pain, such as fibromyalgia, and can also relieve emotional disorders, anxiety and depression." Manuel Arias Gomez, an expert from the Spanish Society of Neurology, said.

　　Laughter therapy

　　Therefore, the so-called "laughter therapy" has appeared as an auxiliary method in the treatment of some diseases. More and more hospitals have recruited volunteers, usually artists, to bring warmth to the cold hospital environment. At present, a number of organizations have sprung up in Spain, such as Smile Doctor of theodora Foundation, Clowns Without Borders, and Smile Medicine, which are dedicated to promoting the laughter therapy.

　　Madrid psychologist Begonia Cabello has devoted herself to studying the relationship between health and humor and how it can be used by medical staff for many years. "I don’t think enough attention is paid to the way to help patients relieve their pain through emotions." She pointed out.

　　"It turns out to be really effective: when the patient is refreshed, the recovery situation can be more ideal. This has been verified not only in children and patients, but also in adults and the elderly. " Cabello said. Humor, like exercise, is our best "tonic", a healthy living habit and the most accessible "medicine". (Compile/Han Chao)

　　Li dongzeng

　　editorial comment/note

　　Recently, a case of bubonic plague was confirmed in Wulate Zhongqi, Bayannaoer City, Inner Mongolia Autonomous Region. Subsequently, Inner Mongolia Autonomous Region announced that three plague foci had been discovered, and close contacts had been observed in isolation at home. This is the second case of plague in Inner Mongolia since last November. Because there have been many plagues in human history, many people turn pale at the sight of them. In fact, today, through effective preventive isolation measures and treatment, plague has long been less terrible. In this issue, we will introduce the spread characteristics and prevention methods of this disease in detail.

　　one

　　The infectivity of different plague is high or low.

　　There are three common types of plague, namely bubonic plague, pneumonic plague and septicemic plague. Plague is usually transmitted from animals to people through rat fleas biting the skin. After a rat flea carrying Yersinia pestis bites a person, Yersinia pestis invades the body from the skin and first reaches the nearest lymph node, causing inflammation of the lymph node, which leads to high fever and swollen lymph nodes. The swollen lymph nodes can be felt from pigeon eggs to the size of eggs, which is bubonic plague.

　　If patients with bubonic plague are not treated in time, swollen lymph nodes may fester and rupture. These pus are also contagious and may be infected if they are touched. Yersinia pestis may also spread to the blood and lungs, becoming septicemic plague and pneumonic plague.

　　Pneumonic plague developed from bubonic plague is called secondary pneumonic plague, and patients with pneumonic plague will have severe pneumonia. There is Yersinia pestis in the respiratory secretions of patients with pneumonic plague, which is highly contagious. Others will be infected after inhalation. People who inhale Yersinia pestis from the respiratory tract can directly suffer from pneumonic plague, which is called primary pneumonic plague. Whether it is primary pneumonic plague or secondary pneumonic plague, the manifestations are similar, and they all have the ability of respiratory transmission. Plague spread from person to person is mainly pneumonic plague.

　　Bubonic plague is the most common, but the risk is lower than pneumonic plague, and it is generally not contagious. However, patients with pneumonic plague are highly contagious, and the mortality rate is relatively high if they are not treated in time.

　　When Yersinia pestis spreads into the blood from lymph nodes or lungs, it may become septicemic plague. Septic plague is rare, but it is the most dangerous and has a high mortality rate. If the patient is not rescued in time, he may die within 1 to 3 days after onset. Septic plague appears ecchymosis because of bleeding under the skin, and the skin is purple-black. Therefore, it was called "Black Death" after the outbreak of plague in medieval Europe.

　　2

　　There is little chance of infection without entering the epidemic focus.

　　The main sources of infection of plague are rats and other rodents, and in China, it is mainly Rattus and Marmota. Other animals such as rabbits, foxes, wolves, camels and some domestic animals such as cats, dogs and sheep can also become sources of infection. The spread of plague among animals is mainly due to being bitten by rats and fleas.

　　Plague itself is spread among animals. There are 12 types of plague natural foci in China, distributed in 19 provinces, and animals in these natural foci may carry Yersinia pestis. Under normal circumstances, plague will not infect humans, but some people are at risk of being infected because of their professional needs or because of travel and exploration. Therefore, the staff in pastoral areas are often high-risk people infected with plague. People who enter pastoral areas are most likely to be bitten by rat fleas in the lower limbs, so the most common symptom of bubonic plague is swelling and pain of inguinal lymph nodes. There are also some people who enter the plague natural focus because of hunting or traveling, and they are also at risk of infection after contacting animals. If you strip animals suffering from plague, you may be infected by rat flea bites, or you may be infected by skin wounds touching the blood and body fluids of sick animals. Plague infected by stripping animals is more common in axillary and cervical lymph nodes of upper limbs.

　　If ordinary people do not enter the natural focus of plague, there is little chance of being infected with plague, and rats in urban areas usually do not carry Yersinia pestis. If you plan to travel to the plague natural focus, you must know the local plague situation in advance, try to keep a distance from wild animals, and don’t get in touch with the woodchuck when you see it. When entering the grassland, try to wear long trousers and gloves, avoid being bitten by rats and fleas, don’t sit and roll on the grassland, don’t picnic and camp on the grassland, and try to reduce the risk of infection.

　　three

　　Symptoms and treatment after plague infection

　　People infected with plague have different symptoms according to different types. The common characteristics of plague patients are rapid onset, repeated high fever, chills, shortness of breath, rapid heartbeat and severe headache. The symptoms of bubonic plague are mainly swelling and pain of lymph nodes, mainly groin, armpit and neck, which are generally unilateral swelling and pain. Patients dare not move easily when the pain is severe. The bubonic plague may be misdiagnosed as other causes of lymph node swelling and pain, such as acute lymphadenitis, lymphadenopathy caused by filariasis, tuberculosis of lymph nodes, etc., but other diseases with lymphadenopathy usually start slowly and develop less rapidly than bubonic plague.

　　Pneumonic plague is characterized by severe chest pain, cough, expectoration, hemoptysis, dyspnea and wheezing. Pneumonic plague is easily misdiagnosed as common bacterial pneumonia or viral pneumonia, so it needs to be distinguished from other pulmonary infection diseases, including lobar pneumonia, pneumonia secondary to influenza, novel coronavirus and so on.

　　Septic plague can be characterized by high fever, no increase in body temperature, unconsciousness, confusion and even coma, extensive bleeding, ecchymosis, cyanosis and necrosis of the skin, and some patients’ bodies are purple and black after death. Septic plague is easily misdiagnosed as coma and shock caused by other reasons, such as hemorrhagic fever with renal syndrome, septicemia caused by epidemic cerebrospinal meningitis, epidemic Japanese encephalitis spread by mosquito bites, shock caused by staphylococcus aureus or streptococcus infection, etc.

　　After people are infected with plague, the disease can be effectively controlled through timely drug treatment. At present, the treatment of plague is mainly antibacterial treatment, supplemented by symptomatic support treatment. Antibacterial treatment refers to the use of antibiotics to sterilize. Streptomycin is the most effective antibiotic against Yersinia pestis, especially in the treatment of pneumonic plague, mainly by intramuscular injection, which can be injected continuously for 10 days. Gentamicin can also be used in the case of human infection with plague. Tetracycline has bacteriostatic effect, which is effective for mild patients. It can be taken orally or used together with other antibiotics. Sulfonamides are widely used in the treatment and prevention of plague. Sulfonamides are the earliest synthetic antibacterial drugs, which have good curative effect on plague, and they are easy to use, stable in nature and low in price. Symptomatic support therapy refers to helping patients recover as soon as possible by means of antipyretic analgesia, anti-shock, respiratory support and nutritional support.

　　four

　　What should I do if I find a mouse at home?

　　Domestic hamsters and rabbits usually don’t have access to wild animals, and animals don’t naturally carry infectious diseases. Without the source of infection, they won’t be infected, so there is no need to worry about domestic hamsters and rabbits catching plague. However, rats, rabbits and other animals do have a lot of bacteria in their mouths. After being bitten, it is necessary to disinfect the wound in time to avoid bacterial infection. If the wound shows signs of infection such as redness, swelling, pain and skin color change, you need to seek medical attention in time.

　　Families find that rats need to be scientifically killed. The first is to clean up the dead corners and garbage in time to reduce the living space of rats. Secondly, try to block all the passages that mice may enter and leave the room, such as air-conditioning pipe holes and sewer holes, so that mice have nowhere to hide and can’t enter the room. Around houses, corridors and other areas, compliant rat traps, rat boards and rat poison can be placed in places where rats are infested, and eye-catching signs should be made at the same time to prevent others, especially children, from accidentally contacting rat poison.

　　Don’t put snacks in the house at will. The food and all kinds of food in the house should be stored out of the reach of mice. If conditions permit, community managers should invite professional rodent control companies to carry out rodent control in a unified way to improve efficiency. If you find dead rats at home, don’t touch them with your bare hands to avoid being bitten by rats and fleas. You can wear long trousers, masks and gloves, collect the dead rats in sealed plastic bags, and contact the community property management department to dispose of the dead animals.

　　Plague prevention includes bubonic plague prevention and pneumonic plague prevention. The bubonic plague is mainly caused by the bites of rats and fleas on animals, so the prevention of bubonic plague by ordinary people is mainly to avoid contact with animals in the natural focus of plague, and to prevent rats and fleas. If you must enter the epidemic area, you can wear long trousers, boots and gloves, and try not to expose your skin to avoid being bitten by rats and fleas.

　　During the tour, everyone should try not to touch wild animals, including wild animal carcasses. Don’t buy wild animals. If you find dead animals on the roadside, you should report them to the local health and disease control departments in time.

　　If you are just traveling, you can do these preventive measures well, and you don’t need to use drugs in advance to prevent it. If you are bitten by rat fleas in areas with plague, or have close contact with patients with pneumonic plague without protection, you can use tetracycline, doxycycline, sulfanilamide and other drugs to prevent it. (Author: Deputy Chief Physician, Department 2, Infection Center, Beijing You ‘an Hospital)

Wen | Hong Kong Stock Research Society

On November 23rd, Netease Cloud Music announced the launch of the initial public offering in Hong Kong. The co-sponsors of the listing are Bank of America Securities, CICC and Credit Suisse.

According to the announcement, Netease Cloud Music will publicly issue 16 million common shares worldwide, with the offering price range of HK$ 19-220 per share, and plans to raise HK$ 3.04-3.52 billion (about RMB 2.49-2.89 billion), with an over-allotment right of no more than 15%. It is estimated that the valuation of Netease Cloud Music will be between 39.47 billion and 45.71 billion Hong Kong dollars (about 32.37 billion to 37.48 billion yuan) after listing.

According to the prospectus, Netease Cloud Music introduced Netease, Sony Music Entertainment and Orbis Investment Management Co., Ltd. as cornerstone investors, with a total subscription of 350 million US dollars (about 2.73 billion Hong Kong dollars). According to the plan, Netease Cloud Music will be officially listed on December 2nd with the code "9899.HK".

What is the valuation level of Netease Cloud Music with a stock price of HK$ 190-220?

According to the calculation of the prospectus, assuming that the over-allotment option has not been exercised, the shares raised by Netease Cloud Music in public account for 7.7% of the total issued shares. Based on the calculation of HK$ 19-220 per share, its valuation is between US$ 5.065 billion and US$ 5.87 billion when converted by exchange rate.

Netease Cloud Music reached 184 million monthly users in the first three quarters; The number of online music paying users was 27.52 million, an increase of over 93% year-on-year; The online music payment rate reached 14.9%.

In December 2018, Tencent Music landed on the New York Stock Exchange with a valuation of US$ 21.3 billion. The current market value is about US$ 12.9 billion, and the valuation of Netease Cloud Music is about 40% of Tencent Music. Judging from the number of users and financial situation; The cumulative MAU of Netease cloud music online music service and social entertainment is a quarter to a fifth of TME; And compared with TME, the revenue is about one fifth. However, compared with the market value of TME, the current valuation of Netease Cloud Music is obviously higher than its equivalent value. It shows that the capital market recognizes and values its content community.

This optimism should mainly come from Netease Cloud Music’s unique community route, original music advantages and highly sticky young users; It is optimistic about its long-term development. Recently, Xiaohongshu completed a new round of $500 million financing, with a market value of $20 billion after the investment. Community concept stocks are still promising investment targets in the capital market.

As far as community products are concerned, compared with the market value of bilibili and other content communities, the valuation of Netease Cloud Music is still in the low range. Bilibili’s monthly income in the third quarter of this year was 267 million, and its market value exceeded HK$ 200 billion. In contrast, Netease Cloud Music had a monthly income of 184 million in the first three quarters, and the highest valuation was only HK$ 45.7 billion, which was obviously underestimated.

Recently, Zhihu released its third quarter financial report, with an average monthly active users of 101.2 million and an average monthly paid members of 5.5 million. At present, the market value of Zhihu is about $4.6 billion. Netease Cloud Music’s monthly activity is about 1.8 times that of Zhihu in the same period, but its valuation is similar, which shows that its community valuation has not been fully reflected.

Due to the recent correction of China Stock Exchange, Internet community enterprises are at a low market value. When bilibili was first listed in the US in 2018, its market value was only $3.2 billion, and its share price really broke through more than two years after listing. In the long run, the valuation of Netease Cloud Music is seriously underestimated, and there is still much room for growth in the future.

Is the "first share of the music community" valuable after the copyright is not independent?

According to the prospectus, Netease Cloud Music’s revenue from 2018 to 2020 was 1.1 billion yuan, 2.3 billion yuan and 4.9 billion yuan respectively. In the first three quarters of 2021, the total revenue was 5.1 billion yuan, a year-on-year increase of 52%; Among them, online music revenue increased from 1.85 billion yuan in the same period of 2020 to 2.44 billion yuan, social entertainment and other sectors revenue increased from 1.52 billion yuan in the same period of last year to 2.67 billion yuan, online music service revenue accounted for 47.7%, social entertainment services and other income accounted for 52.3%.

From the cost side, the proportion of Netease Cloud Music content service cost to revenue has gradually decreased, and the gross loss has continued to narrow. At present, the gross profit margin has turned positive. In terms of revenue growth rate, Netease Cloud Music also far exceeds the overall level of the industry, reaching over 100% in 2019 and 2020, and still reaching 60.0% in the first half of 2021, about twice the growth rate of the industry. In the first half of 2021, the adjusted net loss of Netease Cloud Music narrowed to 500 million yuan year-on-year, and the gross profit margin increased significantly and turned positive to 0.4%.

It is worth noting that at present, most of Netease Cloud Music’s losses are caused by changes in the fair value of convertible redeemable preferred shares. After listing, this part of the loss will disappear with the completion of the share conversion (the latest one will expire on October 23, 2023) and will not lead to the outflow of cash flow.

In July this year, the exclusive copyright of music was banned. For the online music market, this means that the industry has returned to a level playing field. Affected by this, Netease Cloud Music has recently reached copyright cooperation with Modern Sky, Hong Kong Emperor Entertainment and China Record Group. Many famous artists, bands and musicians, such as Nicholas Tse, Joey Yung, Twins, New Pants, Tong Yang and Wu Tiao, have returned. According to the analysis of Western Securities, under the premise of gradually eliminating copyright monopoly in the music industry, the core competition of online music platform will focus more on ecological construction and user operation experience, and Netease Cloud Music has advantages in these aspects.

Hong Kong stock policy is favorable and frequent attention is paid to high-growth technology Internet enterprises.

This year, the global capital market continued to fluctuate, and many Internet companies decided to suspend the IPO process. Recently, however, with the stabilization of the market, the HKEx has also released a number of positive signals, including optimizing and broadening the secondary listing mechanism, and including technology Internet stocks such as Netease, JD.COM and Xinao Energy in the Hang Seng Index, so as to attract more enterprises to come to Hong Kong and return to Hong Kong for listing. Netease Cloud Music, as the first Internet company to officially launch IPO, also shows the strong endogenous motivation and development potential of the music community.

Compared with bilibili’s market value of more than 20 billion US dollars, and Xiaohongshu’s valuation of 20 billion US dollars; If Netease Cloud Music operates properly and the fundamentals continue to improve, there should be more room for growth.

After the reform of the listing system of the Stock Exchange in April 2018, attracting more relevant funds and enterprises to IPO in Hong Kong became the focus of work, and more and more Chinese stocks "returned" to Hong Kong for secondary listing. The relevant planning of the Stock Exchange shows that it will continue to develop Hong Kong into a large global and regional enterprise for major listing or secondary listing; andraise fundsTo attract global investors interested in investing in companies in the Asia-Pacific region and mainland investors seeking international investment opportunities.

Recently, Weibo also passed the hearing of Hong Kong stocks. Netease Cloud Music officially launched the IPO, and the recovery of Internet stocks in the Hong Kong stock market may have gradually occurred.

　　Editor’s note:"Good health is the capital of revolution", but in busy life, people are often busy with work and eager to socialize, but they ignore good health. In fact, with a little attention and early prevention, health is around us. People’s Health Network launched the column "Know early and know early" to collect and sort out the health knowledge that you usually ignore, be your health think tank, and carry out health with you to the end!

　　How much does the kidney work every day?

　　Chen Min, chief physician of Department of Nephrology, Peking University First Hospital, and deputy director of Peking University Institute of Nephrology: The human body has two kidneys, which are located on both sides of the spine and are about the size of a fist. The "blood filtration project" needs 1.7 million to 2.4 million nephrons. Nephron consists of renal corpuscle and renal tubule, and renal corpuscle includes glomerulus and renal capsule. During the day and night, human blood has to be sieved by the kidney for 40~50 times to ensure that the waste produced by metabolism is excreted in time, and the workload is very heavy.

　　The kidney filters about 1.2 liters of blood per minute, accounting for about 24% of the cardiac output. When the blood enters the kidney, the glomerulus filters out substances such as water in the plasma; The filtered substances enter the renal capsule to form protourine, but useful components such as protein, amino acids and sugar remain. After the renal tubule "receives" the original urine, it reabsorbs the useful components, and at the same time discharges the hydrogen ions and ammonia ions that are not needed by the human body to form urine. In this process, nephron maintains the balance of water and electrolyte.

　　In addition to these, the kidney also participates in endocrine regulation, which can release a variety of hormones, such as renin, prostaglandin and erythropoietin, which can help regulate blood pressure, promote the metabolism of active vitamin D, maintain normal bone metabolism and regulate the production of red blood cells.

　　Do four things well to prevent renal failure

　　Chen Min, chief physician of Department of Nephrology, Peking University First Hospital, and deputy director of Peking University Institute of Nephrology: The onset of renal diseases is hidden and difficult to detect. If early detection and early intervention can significantly reduce the complications of patients and significantly improve the survival rate. Patients with diabetes and hypertension are the most high-risk groups of renal diseases. In addition to actively controlling blood sugar and blood pressure, such people need to pay attention to renal function regularly and regularly detect urinary protein levels and serum creatinine levels. Even healthy people should do the following to care for delicate kidneys.

　　Don’t overeat. Eating too much food at one time will not only increase the burden on the digestive system in a short time, but also produce too much metabolic waste and increase the burden on the kidneys. Long-term overeating can also induce hypertension, diabetes, etc., which will lead to secondary nephropathy. It is suggested to eat some fresh fruits and vegetables such as apples properly, which is beneficial to kidney health.

　　Avoid repeated dehydration. Repeated dehydration caused by high temperature environment is related to the increased risk of chronic renal damage. During dehydration, the secretion of angiotensin and antidiuretic hormone increases, renal blood vessels contract and urine is concentrated. If you don’t replenish water in time, dehydration will be serious and blood volume will be insufficient, which will lead to kidney hypoxia and blood flow reduction, and eventually lead to kidney damage.

　　Pay attention to the urine situation. The most intuitive manifestation of kidney problems is urine changes, such as obvious deepening of color, obvious foam and sudden increase of nocturia. In these cases, you should seek medical attention in time, especially those who are accompanied by obvious weight gain and edema, and are likely to have kidney disease.

　　Pay attention to regular physical examination. People aged 45 and above have to undergo physical examination every year. Those who have a family history of kidney disease, or have a history of diabetes, hypertension, proteinuria and gout, and often take antibiotics and nephrotoxic Chinese medicines, it is best to check once every six months to be alert to renal failure.

　　Soaking feet at nine o’clock in the evening is the best way to protect the kidney.

　　Jiang Haitao, Deputy Chief Physician, Department of Cardiology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine: It is most appropriate to soak your feet in warm water from 9: 00 pm to 11: 00 pm, which can attract our spirit to the lower limbs. Spirit plays a leading role in qi and blood, and qi and blood will descend if you concentrate on it. For some mental workers, it is very useful for the spirit of qi and blood to descend, because after thinking about the problem for a day, the spirit is concentrated on it, and the brain is more excited, so it is more difficult to fall asleep at night. After soaking feet in warm water, the spirit and qi and blood are easier to return, that is, to return to their base camp, and the kidney dominates the storage of essence, so it is the kidney that is replenished after collection.

　　The kidney meridian of human body starts from the first step. After soaking feet in warm water, it plays a warming role and is a benign stimulus to the kidney meridian, which will naturally play a good role in the kidney. Therefore, although no measures have been taken for the kidney, the meridian can also play a role in tonifying the kidney.

　　It should be noted that the water temperature of soaking feet must be moderate, not too hot or too cold. If the water temperature is too hot, it will not help the kidney to collect, but will make people more excited, thus increasing the consumption of kidney essence; If the water is too cold and cold, the meridians will be blocked, and the cold will enter the abdomen along the meridians, and its harm is self-evident.

　　These two conditions can cause acute renal failure.

　　1. excessive exercise. Men Wenjin, Deputy Chief Physician, Department of Nephrology, beijing jishuitan hospital: Excessive exercise may lead to acute renal failure. This is because sudden strenuous exercise is likely to cause muscle injury, which will lead to rhabdomyolysis, and then lead to the increase of myoglobin. Myosin itself will also be decomposed into nephrotoxic components in the body, which will cause further damage to renal tubules and lead to acute renal failure.

　　The common causes of soy sauce color are rhabdomyolysis and urinary system infection. It is normal to cause muscle damage during exercise, but excessive exercise causes rhabdomyolysis, myoglobin in cells enters the blood, and urine will show an abnormal dark brown color. Myoglobin is dissolved too much, which can not be discharged quickly, causing blockage in the kidney, which will lead to acute renal failure.

　　2. High voltage electric shock. Dr. Wang Bo, Emergency Department of Changping District Hospital, Beijing: High-voltage electric injuries often burn large areas of muscles, even involving bones, with large fluid loss, which is more prone to shock than general thermal burns. In addition, a large amount of hemoglobin and myoglobin are released, resulting in severe hemoglobinuria and myoglobinuria, which will lead to acute renal failure. Severe acute renal failure often requires hemodialysis according to the condition.

　　Eight signals indicate that the kidney is ill.

　　Lun Lide, Director of Nephrology Department of Air Force General Hospital: 1. Eyelid or lower limb edema: The kidney will lead to the impairment of water and electrolyte regulation function, causing the increase of water and sodium in the body, and water often accumulates in the loosest tissue or the lowest part of the body, such as eyelids or lower limbs.

　　2. Headache, fatigue, memory loss, poor sleep: Nephropathy is characterized by headache, fatigue, memory loss, poor sleep, etc., mostly caused by hypertension, especially young people who have unexplained blood pressure rise should be alert to kidney diseases.

　　3. Foamed urine: When the protein and urine sugar in urine increase, foamed urine can appear, and there is a fine foam floating on the surface of urine, which is not easy to disappear. You should be alert to proteinuria; If the bubble is large and disappears very quickly, we should be alert to whether the urine sugar rises.

　　4. Changes in urine volume: Normal people’s metabolism is slow after falling asleep, and nocturia is significantly less than that during the day. They should not urinate at night or only pass once, and the nocturia is about 1/4 ~ 1/3 of the total amount in 24 hours. If it is often more than 2 times, nocturia is more than that during the day, which may indicate renal insufficiency.

　　5. Abnormal urine test: If protein or occult blood is positive in routine urine test, it may be asymptomatic proteinuria or asymptomatic hematuria, and urine protein quantification or urine phase microscopy should be done in time.

　　6. Complications with other diseases: Many diseases are prone to kidney damage, such as hypertension, diabetes, gout and polycystic kidney disease. Patients with these diseases should have regular urine tests.

　　7. Anemia: Patients with chronic renal insufficiency above moderate degree often have anemia, fatigue, dizziness, pallor and other symptoms, which is often caused by renal insufficiency leading to decreased secretion of erythropoietin by the kidney. Therefore, in the case of unexplained anemia, besides considering blood system diseases, we should check whether there is kidney disease.

　　8. Loss of appetite: Patients with early uremia often have symptoms such as loss of appetite, nausea and itchy skin. Therefore, patients with these symptoms, especially those with hypertension and anemia, must check their renal function.

　　What needs to be emphasized here is that low back pain is not necessarily kidney disease. Low back pain, which people often say, refers to the pain of the whole back and even the lumbosacral part. There is no sensory nerve distribution in the renal parenchyma, so it is painless, and the pain in the renal area that patients feel is mostly caused by the involvement of renal capsule, ureter and renal pelvis. Some patients with nephritis and nephrotic syndrome only have slight discomfort in the waist and feel sore, and rarely have obvious low back pain. (People’s Health Network is integrated from Life Times and Health Times)

On March 6th, HarmonyOS Zhixing’s two high-profile models, the 2025 model and the official opening of the pre-sale, set off a boom in the automobile market. Among them, in 2025, the pre-sale price of the M9 for the border is 478,000 yuan, and that of the M8 for the border is 368,000 yuan. It is reported that the 2025 M9 will be listed in shock this month, and the M8 is scheduled to officially meet with consumers in April.

Wenjie M8 is positioned as "flagship SUV of family wisdom", with a wheelbase of 3105mm, which is only 5mm shorter than Wenjie M9, the same as the wheelbase, and the body size is close to it. It is available in two versions, 5-seat version and 6-seat version, to meet the travel needs of different families. Judging from the pre-sale price, the M-8 card in Wenjie fills the gap between the M-9 card and the M-9 card in Wenjie, further improves the product matrix of HarmonyOS Zhixing, and enters the high-end SUV market of new energy together with the M-9 card in 2025. In terms of power, M8 will simultaneously introduce two power forms: extended range and pure electricity. The extended range version is equipped with a range extender with a power of 1.5T and 118kW, and uses a driving motor with the front 165kW and the rear 227kW. The maximum speed is 200km/h, and its strength cannot be underestimated.

The 2025 model M9 was declared in February this year, including plug-in extended range and pure electric power, and equipped with Contemporary Amperex Technology Co., Limited ternary lithium-ion battery. This change has been upgraded in terms of intelligent driving hardware, which further enhances the intelligent driving ability and brings users a more advanced travel experience. It is worth mentioning that HarmonyOS Zhixing also provides optional original hardware upgrade scheme for the owners of the current M9 model, and at the same time, the current model will continue to upgrade the software features of OTA, so that the old car owners can also enjoy the constantly upgraded service. Externally, the 2025 model M9 adds the color of Jinrui red, which is more unique and distinguished. In terms of seats, 5-seat version and 6-seat version are available for consumers to choose freely. In addition, the new car is also equipped with ten black technologies, such as Huawei’s advanced intelligent driving, Xuanwu hard-core body, Huawei Turing platform and intelligent privacy windows, etc., to improve the performance and quality of vehicles in all directions.

After the pre-sale was opened, the market response of the two models was extremely enthusiastic. Wen Jie M9 2025 pre-sale 6 hours small order over 11000 units; The pre-sale price of the M8 started from 368,000 yuan, and the small order exceeded 21,000 units in 6 hours, and the small order exceeded 7,500 units in 1 hour after the opening of the reservation, showing consumers’ high recognition and expectation for these two new cars.

Yu Chengdong, managing director of Huawei, chairman of BG, and chairman of BU, a smart car solution, said that the launch of the M8 and the M9 in 2025 is another important layout of HarmonyOS Zhixing in the field of new energy vehicles. With the advantages of Huawei’s full-stack technology, ever-changing luxury space, all-dimensional safety and more personalized selection, these two models are expected to stand out in the highly competitive new energy vehicle market and bring consumers better and smarter travel choices.

Judging from the market competition pattern, there are relatively few participants in the 400,000-class hybrid SUV market, and the external competing products of M8 are mainly L9. According to the analysis of Ping An Securities Research Report, the expansion trend of the extended-range market is clear, and the customer M8 is expected to replicate the successful experience of the customer M9, accept the sinking market bonus of the customer M9, and become an explosion-proof vehicle of 400,000 yuan. It is estimated that the steady-state monthly sales of the customer M8 will reach about 15,000 vehicles. In the 500,000-class SUV market in 2025, with its continuous product upgrade and technical advantages, it is expected to continue the brilliant achievement of the 500,000-class sales champion for 11 consecutive months.

With the opening of the pre-sale of the 2025 model, the layout of HarmonyOS Zhixing in the new energy vehicle market is more perfect and the product matrix is more abundant. The listing of these two new cars will bring more quality choices to consumers, and their performance in the market in the future is worth looking forward to.

　　When she was discharged from the hospital, she took a picture at the gate of the hospital.

　　Her husband records the changes of her illness on the desk calendar every day, and the photos are provided by Piao Piao Sao.

　　Oral speaker: 53-year-old female, Piaopiaosa (net name), emergency doctor of Wuhan Eighth Hospital.

　　On February 16th, the doctor named Piao Piao Sao was discharged from the hospital and went home for 6 days. Half a month ago, she thought she would never come back.

　　Recalling the 20 days from illness to critical illness to recovery, Piao Piao sighed that "the disease developed rapidly beyond imagination". As a medical worker, she wants to remind all the patients who are being treated with her own experience that COVID-19’s clinical manifestations are diverse, with different degrees of severity, and her condition changes quite quickly, sometimes within a few hours. Early detection, early diagnosis and early treatment are the key. Especially when there is any discomfort in your body, don’t bear it. You must inform the doctor at the first time, which is probably the key point to decide life and death.

　　For hours, I was so asymptomatic that I couldn’t walk

　　I have been sitting there since the emergency department was changed into a fever clinic.

　　On the morning of January 23rd, I took my temperature as usual: normal. I ate a bowl of egg noodles and rushed to the hospital. On that day, there were still many patients.

　　At 9 o’clock in the morning, I received a notice from the hospital, asking us to take time to do a CT scan. I usually have the habit of fitness, and my health has always been very good. My colleagues call me Iron Man. But I took the CT as required. "There is something wrong with the film, 4 places!" When I got the CT results, my heart thumped and I began to think about when I was recruited.

　　I have taken my temperature every morning since I went to the fever clinic. On the 22nd, there were a lot of patients. Although they called each other, there were several patients and their families standing in front of me as soon as they entered the clinic. The head nurse was worried that the air in the clinic would not circulate, so she opened the window. I sat by the window and felt a little cold, so I closed the window. She was worried that the air in the clinic was not circulating, and I felt cold. We kept opening and closing the windows, perhaps because of the cold, or because we were too tired to work overtime for several days in a row. In short, our immunity declined. This is the only reason I can think of.

　　I don’t have a fever, and I don’t have any symptoms. I should be in the early stage. I should be able to get well soon when I go home to take medicine. I quickly diagnosed myself. I went to the pharmacy to get moxifloxacin, oseltamivir, Abidor tablets and Lianhua Qingwen capsules, and went back to the office to pack my things and go home. Feeling a little hot in my head, I took out a thermometer and measured it: 38.7 degrees. I have a fever. I decided to go home at once.

　　It only takes five or six minutes to walk from home to the hospital. When I get home, I’m going to take a bath and then sleep. Before I entered the bathroom, I began to have a severe headache and vomiting, and I had no energy at all. "I heard that you were recruited?" My brother called. "There is something wrong with taking CT, and people are a little uncomfortable. I won’t tell you first." At this time, I have no strength to hold my mobile phone, and I just want to hang up quickly.

　　My husband went back to his hometown, and I was the only one at home. At this point, my whole body is extremely weak. The disease is developing so fast that I didn’t expect it. I must go to the hospital at once. The director’s phone call came in. He was infected a week earlier than me, saying that he knew my situation and immediately sent someone to pick me up at the gate of the community. From home to the door of the community, it usually takes only two or three minutes, and I walked for more than 20 minutes that day. For the first time, I feel that the road is so difficult and long. If only someone could carry me. A doctor and two nurses in the emergency department were already waiting at the door, and they pushed me to the hospital by flat car.

　　The fever has gone down, and I thought I was getting better.

　　I was admitted to the hospital. Woke up again, it was the next afternoon, and I had a high fever for a day and a night.

　　After treatment, the body temperature dropped quickly. During my stay in the Eighth Hospital, my temperature was high and low, and I kept sweating repeatedly, and I had to change several sets of underwear a day. The most uncomfortable thing is headache and severe fatigue. The nurse came to give me an injection, and I didn’t even have the strength to raise my hand. I have no appetite at all. I only ate two or two porridge for five days in hospital.

　　On the fifth day, the results of nucleic acid test came out: positive, and I was diagnosed as COVID-19. My husband was very worried about me, so he asked someone to buy albumin and globulin for me, but my temperature never dropped to normal. On the eighth day, I was informed that I was transferred to Jinyintan Hospital in Wuhan for further treatment.

　　There were four people on a transfer car, and there was no oxygen on the car. I opened my mouth as wide as possible and kept panting. "How long will it take to get there?" We kept asking along the way, and it seemed that there was no end in sight for more than 10 minutes.

　　At 1: 00 noon on the 30th, I was admitted to an ordinary isolation ward on the second floor of Jinyintan Hospital, where the attending team was the Shanghai medical team. After hormone shock therapy, my fever dropped the next morning, my chest suddenly became clear, I felt much more comfortable and my spirit improved.

　　I breathed a sigh of relief and thought that my condition was developing in a good direction.

　　On the third day of transfer, his condition turned sharply and he was dying.

　　February 1st, 10th day of hospitalization, 3rd day of transfer.

　　No one expected that my condition would suddenly take a turn for the worse at night: I had difficulty breathing and a severe cough, as if my heart would pop out at any time after running 10 thousand meters. The heart rate is very slow, and there is an indescribable chest pain sweeping through the body. If you move a little, you will be in pain. I think this should be the second counterattack of the virus.

　　I am a doctor. According to the symptoms, I judged that I had endocarditis and pericardial effusion, so I quickly told the doctor about my situation. I vaguely heard the nurse say that "the situation is not very good, and people are dying." I don’t think I can make it tonight myself. Thinking that I might never see my husband and daughter again, I struggled to get through to my husband. "I can’t &hellip; &hellip;” Hearing this sentence, my husband cried with a "wow". Every time I say a word, my chest pains are suffocating. I can only pick the most worrying things and make a simple explanation to him.

　　Soon, the nurse came to draw blood and the doctor added medicine to me. The next day, my test results came out, pericarditis. The doctor said, fortunately, I spoke early and won valuable time for them to deal with it. My life was saved by myself.

　　After that, my situation improved day by day. On the eighth day, I felt that I had recovered almost, and applied for CT and nucleic acid examination. I heard that I wanted to leave the hospital, but my husband worried that I was not well and advised me to stay a few more days. I can’t occupy such precious medical resources. I have to make room for patients who need urgent treatment. In order to reassure him, I sent him photos of three meals a day, and also asked my patients to help me take a video of my exercise in the ward and send it to him.

　　On February 11th, I was discharged from the hospital. After life and death, it seems like a lifetime ago. When my husband came to pick me up, he specially brought the changes of my illness that he recorded for me every day for 20 days. Seeing the familiar fonts on the desk calendar, I burst into tears. Only after experiencing life and death can we know that living is really happy.

　　I’ll be isolated at home for another eight days, and then I can go to work. I am very grateful to my colleagues in the hospital for their care and support, and to all the medical staff of the Shanghai Medical Team of Jinyintan Hospital for their meticulous treatment. I want to go to the battlefield again and fight with my brothers and sisters to the end. I want to see Wuhan filled with fireworks as soon as possible. When the quarantine expires, I will donate plasma and treat more patients with my own blood. (Reporter Liu Xuan)

　　China is the hometown of tea. Chinese has discovered and used tea for thousands of years, and many people like drinking tea very much. However, there is news on the Internet recently that drinking tea is bad for the heart and may even lead to heart disease. Is it true?/You don’t say.

　　In fact, drinking tea is not bad for the heart, and it may even be beneficial &mdash; &mdash; This should start with the special ingredients in tea. Tea is usually rich in flavonoid antioxidants, such as tea polyphenols and catechins, which give tea an attractive fragrance. In addition, tea also contains a lot of caffeine. In the process of making tea, some of these substances will dissolve into the tea. Therefore, tea is actually a drink containing a variety of plant antioxidants and caffeine.

　　Tea is rich in antioxidant substances such as tea polyphenols, which can scavenge human free radicals and have certain benefits to health. Judging from a large number of current studies, drinking tea is good for the heart and cardiovascular system &mdash; &mdash; It may significantly reduce the risk of heart disease and stroke by reducing low-density lipoprotein cholesterol ("bad cholesterol").

　　A study in Journal of American Heart Association took six years to analyze the relationship between the change of high density lipoprotein cholesterol (HDL-C) level in the blood of more than 80,000 Chinese and drinking tea. The results show that the HDL-C level of people who insist on drinking tea for a long time decreases more slowly, and the risk of cardiovascular diseases decreases by 8%, which is beneficial to cardiovascular health.

　　China’s "Food and Health-Scientific Evidence and Consensus" summarizes and analyzes the research on tea and health, and thinks that drinking tea can reduce the risk of diabetes, stroke and cardiovascular diseases. Therefore, it can be considered that drinking tea is not only harmless to the heart, but also beneficial.

　　However, because tea contains caffeine, some people drink too much tea, which will lead to discomfort such as palpitations, so some people worry that drinking tea is not good for the heart. In fact, this is a normal phenomenon, which is called "tea drunk" by the people. As long as you drink it in moderation, there will be no problem.

　　At present, the international research on caffeine is relatively sufficient, and authoritative health institutions believe that moderate drinking of coffee and caffeine will not cause damage to the heart. For example, the American Heart Association, the European Heart Association, the Australian National Institute of Health and Medical Research and other institutions believe that healthy adults drinking coffee in moderation (1 to 2 cups a day, about 200 milligrams of caffeine) will not increase the risk of heart disease and cardiovascular disease.

　　Compared with coffee, there is much less caffeine in tea. The caffeine content in a cup of tea is usually only 40 to 80 mg, which is less than half that of an equivalent cup of coffee. Therefore, it is no problem to drink 3 to 4 cups of light tea, such as white tea and green tea every day; For some strong tea, such as black tea, the caffeine content will be more, but drinking 2 cups will not be a problem. Of course, if your heart and head are really uncomfortable after drinking tea, try not to drink or drink less.

　　According to the data of China Cardiovascular Disease Report 2017, the number of cardiovascular patients in China has reached 290 million, and cardiovascular deaths account for 40% of the deaths of residents, which is higher than tumors and other diseases, ranking first; Moreover, the morbidity and mortality are still on the rise. From the current research, maybe drinking some tea every day can also reduce the risk of cardiovascular disease, which is beneficial to the body.

　　It is worth noting that many people may drink tea in the wrong way. How can drinking tea be beneficial to health?

　　First, don’t drink too much tea or drink too much tea. Drinking a lot of tea, in addition to too much and too strong caffeine intake, tannic acid in tea may also affect the absorption of iron, which is not good for health &mdash; &mdash; It is recommended not to drink more than 4 cups of tea every day. Second, drinking tea every day is best arranged in the afternoon, not too late, so as not to affect sleep. What needs special reminder is that you should try to stay away from sugary tea drinks. At present, there is no evidence that sugary tea drinks also have cardiovascular protection. Therefore, tea drinks should not be used instead of drinking tea, let alone deliberately drinking tea drinks to protect cardiovascular health.

　　(The author is Ruan Guangfeng, Director of Science and Technology Department of Food Nutrition and Information Exchange Center)