Vaccination is the key to immunization planning, and it is also a sharp weapon for China to deal with a series of infectious diseases such as COVID-19.

　　According to the "Immunization Agenda 2030" announced by 26 institutions including the World Health Organization (WHO), the goal is to achieve 90% coverage of basic vaccines for children and adolescents by 2030, and to reduce the number of children who have not been vaccinated at all by half. The "Healthy China 2030" Planning Outline clearly stated that "the expanded national immunization program should be continued, and the vaccination rate of school-age children in the national immunization program should be maintained at a high level".

　　At present, 14 kinds of vaccines under China’s immunization program can prevent 15 kinds of infectious diseases, including hepatitis A, meningitis and rubella, and the coverage population is mainly children aged 0 to 6. However, there are still four kinds of vaccines recommended by WHO that are internationally recognized as cost-effective and have not been included in China’s immunization program.

　　What is the urgency and cost-effectiveness of these four vaccines for patients? How to set relevant evaluation standards? On the occasion of "World Immunization Week", CBN interviewed a number of clinical and immunization planning experts and gave their answers.

　　The dilemma of high price of PCV vaccine

　　The vaccines recommended by WHO but not included in China’s immunization program mainly include Hib vaccine (Haemophilus influenzae type B vaccine), HPV vaccine (human papillomavirus vaccine), PCV vaccine (streptococcus pneumoniae conjugate vaccine) and RV vaccine (rotavirus vaccine).

　　"Streptococcus pneumoniae (SPN) is the main pathogen of community-acquired pneumonia and invasive infection among children in China." Zeng Mei, chief physician of the Pediatric Hospital affiliated to Fudan University, said that according to multi-center research, nearly 80% of patients with invasive pneumococcal diseases are children under 5 years old. "It is urgent to vaccinate this population with streptococcus pneumoniae vaccine."

　　As a pediatric clinician, Zeng Mei has been concerned about the impact of Streptococcus pneumoniae on children and the related immunization planning process for many years. For example, a multi-center clinical study covering 1138 cases of invasive Streptococcus pneumoniae in children from 2012 to 2017 showed that the mortality rate of these invasive Streptococcus pneumoniae diseases was as high as 16.2%, and the proportions of meningitis, bacteremia and bacteremia caused by these diseases were 22.9%, 9.1% and 7.8 respectively.

　　In terms of vaccine supply, at present, there are two kinds of PCV13-valent vaccines available in China. Among them, imported vaccines are suitable for infants aged 6 weeks to 15 months, and domestic vaccines are suitable for infants and children aged 6 weeks to 5 years. PPV23(23-valent pneumococcal polysaccharide vaccine) is used for people over 2 years old who are infected with SPN and have an increased risk of IPD (invasive pneumococcal disease).

　　"In China, there are obvious regional differences in deaths caused by Streptococcus pneumoniae, and about 49% of deaths caused by Streptococcus pneumoniae occurred in the western region. In terms of mortality, the mortality rate in the western region is 17 per 100,000, which is about twice as high as that in other regions. " Wang Weibing, director and professor of the Department of Epidemiology, School of Public Health, Fudan University, said that the vaccination rate of PCV13 vaccine in Shanghai has reached almost 50% in recent years, and the risk of pneumonia can be reduced by about 82% after vaccination, but the vaccination rate in the western region is less than 1%.

　　Wang Weibing further said that from the perspective of economic burden, the price of PCV vaccine in most countries covered by Gavi (Global Alliance for Vaccine Immunization) is about US$ 3.3 per dose. The price of imported PCV13 vaccine in China is about 700 yuan per dose, which still has a certain gap. "The current price also leads to the vaccine not being cost-effective in health economics." .

　　It is necessary to comprehensively consider many factors such as disease, vaccine, vaccination ability and so on when vaccines are included in the immunization program. Wang Weibing told reporters that on the one hand, epidemiological evidence such as the disease burden of influenza and pneumococcal diseases in China is still insufficient. Because pneumonia, influenza and other respiratory diseases usually have similar symptoms, there are many kinds of pathogens that can cause the same disease, which makes it difficult to estimate the disease burden of vaccine-preventable diseases, and it is difficult to observe the effect after vaccination.

　　On the other hand, from the point of view of vaccine supply, because PCV vaccine contains many serotypes, the production process is complex and there are certain technical barriers, which leads to the vaccine supply can not meet the needs of being included in the national immunization plan. However, with the joining of Chinese manufacturers who independently research and develop PCV vaccine, it is believed that the current situation of insufficient supply will be expected to be improved.

　　Significance of free HPV vaccination

　　Since the first government-led HPV vaccine free vaccination project was launched in Erdos city three years ago, at present, Guangdong, Hainan, Jiangxi, Fujian, Tibet and Chongqing provinces have also started or announced that they will launch a global HPV vaccine free vaccination program.

　　According to other data, there are six kinds of HPV vaccines listed in the world, including two bivalent HPV vaccines independently developed by China (one from Wan Tai and one from watson biological). As of March 2023, 126 countries and regions have included HPV vaccine in the immunization program.

　　"In terms of HPV vaccination, people’s acceptance and participation enthusiasm are higher than expected. These explorations may provide important reference for the inclusion of HPV vaccine in national immunization planning decisions." Zhang Jun, deputy dean of the School of Public Health of Xiamen University and deputy director of the National Infectious Disease Diagnostic Reagents and Vaccine Engineering Technology Research Center of Xiamen University, said in an interview.

　　In Zhang Jun’s view, there is no doubt about the health damage caused by HPV infection in China. With the large and stable supply of high-quality domestic HPV vaccines and widely recognized by the public, the independent control of vaccine research and development and the long-term sustainability of supply have become a fact. "At present, HPV vaccines have not been included in the national immunization plan, and the main difficulty lies in the high cost and price of vaccines and the uncertainty of public acceptance."

　　Judging from the bidding price of Jiangsu Province’s previous procurement, the bivalent HPV vaccine in watson biological was 246 yuan/piece, and the bivalent HPV vaccine in Wan Tai was 329 yuan/piece, and three shots were inoculated in the whole process. In addition, the average price of HPV tetravalent vaccine ranges from 800 to 900 yuan per dose, and the total price of three doses of HPV nine-valent vaccine is about 4,000 yuan.

　　"Because the research and development cycle of HPV vaccine is generally more than 10 years, it requires high production facilities and quality control. In order to maintain a virtuous circle of market demand-R&D investment, the pricing of products should not be too low within several years of listing; This may put greater pressure on the country’s budget. " Zhang Jun analyzed the reporter.

　　Du Heng, senior project officer of the Beijing Representative Office of Bill and Melinda Gates Foundation, believes that enterprises will make production capacity layout and arrangement according to market demand, and naturally leave production capacity to the high-priced vaccine market and people with higher payment capacity. The key population that should be vaccinated with HPV vaccine first, that is, girls aged 9-15, can guide the production behavior of enterprises through strengthening the national immunization program and large-scale procurement.

　　Zhang Jun suggested that, on the one hand, a more flexible medical insurance payment mechanism could be considered. For example, formulate affordable medical insurance payment standards, where the expenses within the standards are reimbursed by medical insurance/finance, and the expenses beyond the standards are paid by individuals.

　　On the other hand, on the basis of bidding and purchasing with quantity, considering increasing the time factor, relatively high prices are allowed in the first few years, so that enterprises can recover their costs as soon as possible and obtain reasonable income, maintain their enthusiasm for innovation, and quickly switch to cost pricing or market competition after a certain number of years and more diversified manufacturers, so as to ensure the sustainability of immunization planning policies.

　　Implement a scientific and accurate evaluation standard path

　　Professor Tang Shenglan, co-director of the Global Health Research Center of Duke University in Kunshan and head of the Innovation Laboratory of Vaccine Delivery Research, told the reporter that there have been many mature research results on the key decision-making research and the selection of vaccine varieties for introducing immunization programs for new vaccines in the world, which generally involve three types of indicators.

　　The first category is indicators related to disease prevalence and burden. "For example, malaria is highly prevalent and has a high disease burden in many African countries, so it is necessary to include malaria vaccines in the immunization programs of these countries. However, malaria has been effectively controlled in China. In 2021, WHO awarded China the certification for eliminating malaria. Obviously, malaria vaccine will not be considered in the expansion of immunization programs in China. " Tang Shenglan said.

　　The second kind of indicators mainly focus on the vaccine itself, including its effectiveness, safety, quality, supply capacity and health and economic benefits.

　　The third category of indicators involves financial resources, manpower and material resources. Tang Shenglan analyzed in detail for the reporter. Financial resources mainly refer to whether China’s health financing mechanism can support the expansion decision. Generally speaking, if the budget is abundant this year, it will vigorously expand vaccination, and if the budget is tight next year, it will reduce vaccination coverage (the baby born next year will not be able to enjoy the plan). This obviously violates the principle of fairness. Manpower, every time a new vaccine is added to the immunization program, it means that the workload of vaccination increases and the number of possible vaccine adverse reactions increases; Correspondingly, the inoculation technology of new vaccines needs training, and the results of disease surveillance also need to be reported. Material resources include whether the vaccine distribution has cold chain conditions, whether the monitoring system can "expand" synchronously, and whether the media and grassroots science popularization have enough resources for public science popularization.

　　In the next step, what specific measures and adjustments should be made in immunization planning in various places?

　　Tang Shenglan suggested that, first of all, from the national level, a scientific and dynamic adjustment mechanism of immunization program catalogue can be gradually established, and based on this mechanism, the adjustment plan of national immunization program in the next 5-10 years can be defined, and the market can be shaped through this plan. At the same time, guided by health and fairness, taking into account the local disease burden, financial level and residents’ ability to pay, we will explore and support the gradual inclusion of more cost-effective vaccines in the national immunization plan in different regions, batches and steps, and include high-risk groups such as teenagers, the elderly, chronically ill patients and medical workers in the vaccination scope, so as to accelerate the realization of life-cycle vaccination.

　　Secondly, it is to improve the sustainable financing mechanism of vaccines, which can establish the clear expectations of relevant enterprises for the market. "Practice in some places shows that medical insurance reimbursement or moderate subsidies can effectively incite individuals to share and improve the vaccination rate without significantly increasing the financial burden." For example, Tang Shenglan, Qinhuai District of Nanjing, for example, paid about 670,000 yuan to buy varicella vaccine through finance in 2019, accounting for only 1.10% of the basic public health service expenses in the district, but it increased the coverage rate of the first vaccination by 10 percentage points.

　　Thirdly, improve the research and development of key vaccines through policy guidance. These policy guidance can include: optimizing vaccine review and approval standards, accelerating industrial transformation and upgrading, supporting joint vaccine research and development and production, and leaving room for optimizing immunization strategies; Support the domestic substitution of key vaccines to ensure a stable and sufficient supply of vaccines included in the immunization program.

　　Finally, Tang Shenglan suggested that we can learn from some innovative international procurement mechanisms to balance the risks and benefits of enterprises while adjusting vaccine prices.

　　"For example, in the bidding process in the UK, manufacturers are allowed to give different quotations according to different purchase quantities (often the larger the purchase quantity, the lower the price), so that economies of scale can be effectively utilized and the risks of manufacturers can be reduced. The Canadian government will require provinces or regions to estimate their demand before awarding the contract to manufacturers, and require provinces or regions to purchase at least 75% of their estimated amount, thus forming a quantitative guarantee for manufacturers. " Tang Shenglan said that China can fully learn from the experience of developed countries, start with regional pilot projects, and explore a better procurement model. While reducing the price of non-immunization vaccines, it also enhances the R&D enthusiasm of enterprises and achieves the goal of multi-win.

Original Bajiuling Wu Xiaobo Channel

It may be difficult for pharmaceutical companies to embark on the road of OEM, but it is not a long-term solution after all.

Text/Ba Jiuling (WeChat WeChat official account: Wu Xiaobo Channel)

01

These things you bought online are probably branded products.

Have you bought scar cream, hair tonic, warm palace stickers, diet pills and other health care products online? If these products come from well-known pharmaceutical companies such as Renhe, Tongrentang and Xiuzheng, will you have more trust, even if its price is higher than similar products, will you pay for them?

But in fact, the products you bought are probably not from the pharmaceutical companies’ own factories, but are OEM products.

For example, Tmall’s "Medicine Capital Renhe Flagship Store" has a monthly sales of 10,000+and more than 7,000 comments. According to the product details page, this product is from Renhe Pharmaceutical, but it does not appear in the product list of Renhe Pharmaceutical official website.

According to the approval number of this product "G20180064", minibus found the registration information of this product in official website of the Food and Drug Administration, which showed that the manufacturer was "Guangzhou Aifuyi Biotechnology Co., Ltd.", and the last remark information also stated that its actual manufacturer was: Guangzhou Tengyu Cosmetics Co., Ltd.

Enterprise investigation shows that Guangzhou Aifuyi and Guangzhou Tengyu have no equity relationship with Renhe Pharmaceutical. This is a typical OEM product.

On the platform of investor interaction, many investors have raised a similar topic to Renhe Pharmaceutical, such as "What is the relationship between anti-alopecia lotion and Renhe Pharmaceutical", and they are concerned about the actual relationship between such branded products and Renhe Pharmaceutical.

02

The OEM model has spread to the medical field.

Today, the OEM model has been very popular in all walks of life. The most typical is the Antarctic people. Open a shopping platform, there will be many shops related to Antarctic people, and the products are countless, from shoes and clothing to bedding, from electric irons to gas stoves.

Antarctic people were originally a company that started from making underwear. Since 2008, Antarctic people have closed all the production lines of their own factories, and since then they have changed from "selling products" to "brand authorization", earning a lot of money. In 2019, Antarctic people earned 1.3 billion yuan through brand authorization. In 2020, the gross profit margin of Antarctic OEM service will reach 93.26%.

In recent years, the OEM model has spread to the medical and health care industries. Renhe, Tongrentang, Xiuzheng, Sunflower and many other well-known pharmaceutical companies increase their income through brand authorization.

Taking Renhe Pharmaceutical as an example, according to its 2020 annual report, the company achieved a total operating income of 4.106 billion yuan. The company’s products are divided into self-owned products and OEM products. From the perspective of income, self-owned products and OEM products basically account for half.

The OEM model supports half of the revenue of an old pharmaceutical company, which is enough to prove the dependence of well-known pharmaceutical companies on the OEM model.

Compared with R&D, OEM is obviously an easier shortcut. Accustomed to taking shortcuts, they are even more reluctant to take the difficult but correct path.

According to the third quarterly report of 2021 disclosed by Renhe Pharmaceutical, in the first three quarters, the company’s R&D expenses were 42.76 million yuan, and its revenue was about 3.659 billion yuan. The proportion of R&D expenses in revenue was only 1.1%. According to the annual report of Renhe Pharmaceutical for nearly 4 years, its annual sales expenses are 14-26 times as much as R&D expenses. Renhe’s characteristics of "emphasizing marketing and neglecting research and development" are often criticized by the outside world.

However, this is not the problem of Renhe. According to the survey report of the consulting industry in China, the R&D expenditure of large international pharmaceutical companies generally accounts for 15%-20% of the total sales, while the R&D investment of domestic pharmaceutical companies accounts for only 2%-3% of the sales revenue on average.

03

Want to win by branding? I’m afraid not.

Although the road to OEM is easy, it is not once and for all.

Just like Antarctic people, they thought they could "win" by brand authorization, but these two years have not been easy.

Since July last year, the share price of Antarctic e-commerce has dropped from the highest point of 24.41 yuan to around 7 yuan today, and its market value has evaporated by nearly 40 billion yuan. According to its 2021 semi-annual report, in the first half of 2021, the net profit of Antarctic e-commerce attributable to shareholders of listed companies was 246 million yuan, down 42.85% year-on-year.

The OEM model is like a double-edged sword, which not only contributes a lot of profit to the enterprise, but also brings various negative problems to the brand, such as product quality, word of mouth and even false propaganda.

There are many complaints about branded products of pharmaceutical companies on the websites of Black Cat Complaint and 315 Consumer Protection Complaint. Most of the complaints revolve around "invalid products", "fake goods", "no refund" and "false propaganda".

Minibus searched Pinduoduo for a wound care ointment. According to the industry details page, this product comes from a national brand-Amendment. Its function is "scar removal without leaving any trace", and it has been put on record by the Drug Administration, with good safety effect.

The actual manufacturer of this ointment is "Jiangxi Bingshuangjiefu Industrial Co., Ltd.", which has no equity relationship with Xiuzheng Pharmaceutical and belongs to OEM products.

According to the record number "Ganzhang Machinery Equipment No.20190083" provided by it, the minibus made an inquiry on the website of National Medical Products Administration, and the record information showed: "This product is ointment. The contained components have no pharmacological effects. The ingredients contained cannot be absorbed by the human body. Non-sterile. "

The "intended use" item is blank.

The minibus inquired about other brands of scar-removing ointment of the same type, and the column of "expected use" said "suitable for inhibiting and relieving hyperplastic scars caused by burns, trauma, surgery and other reasons".

In other words, this ointment probably has no scar removal effect. If so, then this product has the problem of false propaganda.

04

How can you post it? Who is responsible for the problem?

Who should be responsible for the quality problems of OEM products? The minibus consulted Chang Dongyue, the director of Shanghai Law and Craftsman Law Firm, and he thought that once the branded goods had quality problems, the brand supplier was the direct responsible person, and the processor was also liable under normal circumstances. Moreover, this is based on the quality problems of legally produced products, and it is necessary to bear civil liability.

However, more and more enterprises don’t talk about "martial arts", and many enterprises alienate OEM into pure lending brands, which is very problematic without any quality supervision on quality. In this case, if the illegal production leads to extremely bad social consequences, the brand and producer of OEM products not only need to bear civil liability, but also need to bear administrative responsibility and even criminal responsibility.

Chang Dongyue also said that the safety of food and drugs is related to people’s right to health and even life. Quality problems may cause irreversible damage to the body, and no matter how strict the quality supervision of food and drugs is. Regrettably, although China’s Food Safety Law, Drug Administration Law and Product Quality Law all stipulate product quality responsibility, the sanctions for violating food and drug safety are still too light, so that the food and drug field in China is still not safe enough. In this regard, the United States and Japan’s practice of using heavy codes to control food and drug safety is quite good and worth learning.

Relying on legal sanctions is the last step. As an enterprise, it should be its duty to abide by the rules. How can have no martial ethics, a post it?

According to Shi Lichen, the founder and strategic marketing expert of Beijing Dingchen Management Consulting Co., Ltd., OEM is not illegal, and the key is how to continue to control quality while authorizing. Whether you are OEM or OEM, consumers only know that they are buying your brand. Pharmaceutical companies should pay special attention to quality, otherwise, as the authorized products become more and more miscellaneous, the quality can not be controlled, and finally the reputation of the main business will be affected, which will not be worth the candle.

05

Difficulties and new ways for pharmaceutical companies

The advantages and disadvantages of OEM mode are very clear, and it can easily make money, but it is difficult to control the quality and the brand is easily damaged. The reason is very simple. The question is, those old pharmaceutical companies that have spent a hundred years settling down should have cherished their feathers. Why are they addicted to OEM?

Shi Lichen explained the reasons behind it: in recent years, the competition in the pharmaceutical industry has been fierce, and the operating pressure of pharmaceutical companies has increased. The old pharmaceutical companies have to find a way out. First, solve the fundamental problems and increase investment in research and development; Second, based on its own cost advantage, to achieve economies of scale. But these two roads are not easy to walk.

"In contrast, the OEM business has almost no cost and high net profit, so those pharmaceutical companies with brand awareness and strong premium ability naturally embarked on this road."

From this point of view, it is difficult for the old pharmaceutical companies to embark on the road of OEM, but this is not a long-term solution after all. Is it possible to open up a new road?

There is indeed a new road that has emerged-the field of cross-border beauty cosmetics and daily chemicals for pharmaceutical companies.

With the strong growth of functional skin care products, pharmaceutical companies such as Renhe, Pien Tze Huang, Tongrentang, Ma Yinglong, Yunnan Baiyao, Panlong Yunhai, Dong ‘e Ejiao and Xiuzheng Pharmaceutical have all set foot in the cosmetic and daily chemical industry.

Pien Tze Huang disclosed the 2020 financial report, and the company achieved operating income of 6.511 billion yuan, a year-on-year increase of 13.78%; The net profit was 1.672 billion yuan, a year-on-year increase of 21.62%. Behind the growth, the cosmetics sector contributed a bit. Its holding subsidiary Fujian Pien Tze Huang Cosmetics Co., Ltd. achieved revenue of 611 million yuan, up 42.01% year-on-year, and net profit of 114 million yuan, up 41.23% year-on-year.

In July this year, Renhe Pharmaceutical announced that it planned to acquire 80% equity of seven cosmetics companies for 719 million yuan. One of them, Shenzhen Miura Natural Cosmetics, has been independently producing Renhe brand cosmetics, and some of the products distributed by the other six target companies come from this company.

In this regard, Shi Lichen analyzed that there is a huge Japanese industry called cosmeceuticals, which is not available in China, but we can make some functional cosmetics. Well-known pharmaceutical companies have natural advantages in making cosmetics across borders. For example, if brands can support the premium of products, they can get higher profit points. In addition, pharmaceutical companies themselves already have strong management teams, marketing teams and capital levels, which are not available to ordinary enterprises.

"The difference is nothing more than that some pharmaceutical companies, such as Renhe, have cultivated Renhe brand cosmetics related products through OEM before, and some products already have a certain market share, brand awareness and user base. At this time, it is logical to conduct mergers and acquisitions. Some pharmaceutical companies have had less involvement in this area before, so they may have to do it from scratch. "

In this way, pharmaceutical companies cross-border to make beauty cosmetics and daily chemical products. Originally, they just wanted to be a sideline through brand authorization. In the future, they may become one of their main businesses and gain new profit growth points by creating explosive IP products.

Author | Li Mengqing | Duty Editor | Zhang Wenlong

Editor | He Mengfei | Editor | Zheng Yuanmei | Tuyuan | vision china

Original title: "Old pharmaceutical companies learn from online celebrity brand. Have you ever bought such branded products? 》

Read the original text

　　The General Administration of Customs announced today (6th) that in the first half of this year, the national customs suspended the export to China of 144 food enterprises that suffered from the COVID-19 outbreak, and at the same time, returned or destroyed the risky imported food to prevent unqualified food from entering the country.

　　According to customs statistics, this year 1-mdash; In June, the national customs conducted a total of 1,098,700 samples of imported cold-chain food, animal and plant products for COVID-19 virus detection; A total of 27,114,400 imported cold-chain foods were supervised for preventive disinfection at ports.

　　Kong Xiaobang, Director of General Department of Import and Export Food Safety Bureau of General Administration of Customs:Since the outbreak of the epidemic, as of July 1st this year, we have randomly selected 296 overseas food enterprises in 60 countries and regions through remote video, and suspended the export of 144 overseas food enterprises with COVID-19 outbreak employees to China, effectively ensuring the safety of imported food in China.

　　At the same time, the customs strictly returns or destroys the imported food with risks to prevent unqualified food from entering the country. 1-mdash this year; In June, the national customs detected 1,070 batches of food that were not allowed to enter the country due to unqualified safety and hygiene items in port supervision, and all of them were returned or destroyed.

　　In addition, the customs has also enhanced the understanding of the safety of imported and exported food in various ways. Today, in addition to Hangzhou, other customs across the country have also launched the "National Food Safety Publicity Week" in 2021, with a variety of publicity, display and Q&A activities to publicize and interpret imported food safety and port food hygiene and safety laws and regulations to import and export enterprises and consumers, and strictly supervise imported food.

　　Zang Juan, Inspection Section of Qianjiang Customs Office in Yuhang, Hangzhou Customs:Consumers can first check whether the food is labeled or labeled in Chinese, and whether the product name, country of origin (region), ingredient list, production date and other information are marked on the label.

　　If there is no such Chinese label on imported food sold in the market, it can be regarded as an informal channel. Secondly, you can also ask the sellers for the Inspection and Quarantine Certificate of Entry Goods issued by the Customs or log on to the website of the General Administration of Customs to check whether the imported food meets the access requirements, so as to ensure that the imported food you buy is imported in compliance.

I. Basic information of the project

Project number: SJZGK20250234

Project Name: Dog Management Security Service of Shijiazhuang Public Security Bureau

Budget amount: 857200

Maximum price limit (if any): 857200

Procurement demand: This project mainly includes: the dog certification service center of the public security police detachment of Shijiazhuang Public Security Bureau and the dog detention center need to hire 18 security guards to provide security services, assist the police to investigate and deal with large dogs and fierce dogs that are illegally kept, take in stray dogs, carry out civilized dog-raising publicity activities, and conduct street inspections on uncivilized dog-raising behaviors.

Duration of contract performance: 12 months.

This project does not accept consortium bidding.

Second, the applicant’s qualification requirements:

1. Meet the provisions of Article 22 of the Government Procurement Law of People’s Republic of China (PRC);

2. Qualification requirements for implementing the government procurement policy: 1. This project is specially designed for small and medium-sized enterprises to purchase; 2 Other qualification requirements for implementing government procurement policies (if any): Inquire through channels such as Credit China (https://www.creditchina.gov.cn), China Government Procurement Network (http://www.ccgp.gov.cn) and China Executive Information Open Network (http://zxgk.court.gov.cn). Not included in the list of parties involved in major tax violation cases, the list of records of serious illegal and untrustworthy behaviors of government procurement, and the list of untrustworthy executors published by the Supreme People’s Court (subject to the results of the purchaser’s inquiry after the bidding deadline).

3. Specific qualification requirements for this project: None.

Third, obtain the tender documents

Time: from April 29th, 2025 to May 8th, 2025, from 00: 00 am to 12: 00 am and from 12: 00 pm to 23:59:59 pm (Beijing time, except legal holidays).

Location: Shijiazhuang public resources trading platform download, website: http://110.249.147.67/G2/, bidders should pay attention to whether the project has any correction announcement in time.

Mode: Other

Price: 0

IV. Deadline for submission of bid documents, time and place of bid opening

09: 30 May 22, 2025 (Beijing time)

Venue: Shijiazhuang Public Resource Trading Platform, website: http://110.249.147.67/G2/.

V. Announcement Period

5 working days from the date of this announcement.

VI. Other Supplementary Matters

According to the "Hebei Provincial Department of Finance Hebei Provincial Government Service Management Office on the issuance of<政府采购公开招标项目全面实行“双盲”评审实施方案>According to the relevant requirements of the Notice, this project adopts a "double-blind" review. The supplier shall make the commercial bid and the technical bid separately according to the requirements of the tender documents, and the bid evaluation committee shall review the commercial bid and the technical bid according to the requirements. Obtain bidding (procurement) documents: log on to Shijiazhuang Public Resources Trading Platform (http://110.249.147.67/G2/) and download the bidding (procurement) documents (*.HBZ). 1. Before obtaining the documents, the supplier shall register (telephone number 0311-89668589) according to the "Government Procurement Supplier Operation Manual 20210701", and consult the CA certificate business: the national public resource trading platform (Hebei Province) shall handle the CA certificate business in http://publicservice.hebpr.gov.cn:8181/. Download Path: Business Guide of Shijiazhuang Public Resource Trading Network (http://110.249.147.67/G2/)-Download Center 2. After obtaining the documents, the supplier should download the [Government Procurement] (Bidding) Document Preparation Tool 7.8.2005.2330, the "CA Certificate Driver Installation Program Download Instructions" and the "Government Procurement Response Document Preparation Tool Operation Instructions" before installing these tools. Download path: Shijiazhuang public resource trading network(http://110.249.147.67/G2/) "Business Guide"-"Download Center" Technical Tel: 0311-89868327 3. When opening bids, the supplier shall decrypt the electronic bidding (response) documents with the CA digital certificate. 4. This project is subject to "double blind" evaluation, that is, the evaluation experts are randomly selected from the provincial expert database to realize "blind selection" of the evaluation experts; The commercial bid and technical bid of bidding (response) documents are made separately, and the evaluation committee adopts the open bid evaluation and the hidden bid evaluation for the commercial bid as required, so as to realize "blind evaluation" in the evaluation process. Due to the market subject’s own reasons, the consequences caused by the failure to obtain and submit documents within the effective time shall be borne by the market subject itself.

7. For inquiries about this tender, please contact in the following ways.

1. Purchaser information

Name: Shijiazhuang Public Security Bureau

Address: No.66 Yuannan Road, Shijiazhuang

Contact information: 0311-89667000

2. Information of purchasing agency (if any)

Name: Shijiazhuang Public Resource Trading Center

Address: Xingshi Square, No.87 Shengli South Street, qiaoxi district, Shijiazhuang.

Contact: 0311-89665583

3. Contact information of the project

Project Contact: Gu Yi

Tel: 0311-89667000

VIII. Annexes

　　Li dongzeng

　　editorial comment/note

　　Recently, a case of bubonic plague was confirmed in Wulate Zhongqi, Bayannaoer City, Inner Mongolia Autonomous Region. Subsequently, Inner Mongolia Autonomous Region announced that three plague foci had been discovered, and close contacts had been observed in isolation at home. This is the second case of plague in Inner Mongolia since last November. Because there have been many plagues in human history, many people turn pale at the sight of them. In fact, today, through effective preventive isolation measures and treatment, plague has long been less terrible. In this issue, we will introduce the spread characteristics and prevention methods of this disease in detail.

　　one

　　The infectivity of different plague is high or low.

　　There are three common types of plague, namely bubonic plague, pneumonic plague and septicemic plague. Plague is usually transmitted from animals to people through rat fleas biting the skin. After a rat flea carrying Yersinia pestis bites a person, Yersinia pestis invades the body from the skin and first reaches the nearest lymph node, causing inflammation of the lymph node, which leads to high fever and swollen lymph nodes. The swollen lymph nodes can be felt from pigeon eggs to the size of eggs, which is bubonic plague.

　　If patients with bubonic plague are not treated in time, swollen lymph nodes may fester and rupture. These pus are also contagious and may be infected if they are touched. Yersinia pestis may also spread to the blood and lungs, becoming septicemic plague and pneumonic plague.

　　Pneumonic plague developed from bubonic plague is called secondary pneumonic plague, and patients with pneumonic plague will have severe pneumonia. There is Yersinia pestis in the respiratory secretions of patients with pneumonic plague, which is highly contagious. Others will be infected after inhalation. People who inhale Yersinia pestis from the respiratory tract can directly suffer from pneumonic plague, which is called primary pneumonic plague. Whether it is primary pneumonic plague or secondary pneumonic plague, the manifestations are similar, and they all have the ability of respiratory transmission. Plague spread from person to person is mainly pneumonic plague.

　　Bubonic plague is the most common, but the risk is lower than pneumonic plague, and it is generally not contagious. However, patients with pneumonic plague are highly contagious, and the mortality rate is relatively high if they are not treated in time.

　　When Yersinia pestis spreads into the blood from lymph nodes or lungs, it may become septicemic plague. Septic plague is rare, but it is the most dangerous and has a high mortality rate. If the patient is not rescued in time, he may die within 1 to 3 days after onset. Septic plague appears ecchymosis because of bleeding under the skin, and the skin is purple-black. Therefore, it was called "Black Death" after the outbreak of plague in medieval Europe.

　　2

　　There is little chance of infection without entering the epidemic focus.

　　The main sources of infection of plague are rats and other rodents, and in China, it is mainly Rattus and Marmota. Other animals such as rabbits, foxes, wolves, camels and some domestic animals such as cats, dogs and sheep can also become sources of infection. The spread of plague among animals is mainly due to being bitten by rats and fleas.

　　Plague itself is spread among animals. There are 12 types of plague natural foci in China, distributed in 19 provinces, and animals in these natural foci may carry Yersinia pestis. Under normal circumstances, plague will not infect humans, but some people are at risk of being infected because of their professional needs or because of travel and exploration. Therefore, the staff in pastoral areas are often high-risk people infected with plague. People who enter pastoral areas are most likely to be bitten by rat fleas in the lower limbs, so the most common symptom of bubonic plague is swelling and pain of inguinal lymph nodes. There are also some people who enter the plague natural focus because of hunting or traveling, and they are also at risk of infection after contacting animals. If you strip animals suffering from plague, you may be infected by rat flea bites, or you may be infected by skin wounds touching the blood and body fluids of sick animals. Plague infected by stripping animals is more common in axillary and cervical lymph nodes of upper limbs.

　　If ordinary people do not enter the natural focus of plague, there is little chance of being infected with plague, and rats in urban areas usually do not carry Yersinia pestis. If you plan to travel to the plague natural focus, you must know the local plague situation in advance, try to keep a distance from wild animals, and don’t get in touch with the woodchuck when you see it. When entering the grassland, try to wear long trousers and gloves, avoid being bitten by rats and fleas, don’t sit and roll on the grassland, don’t picnic and camp on the grassland, and try to reduce the risk of infection.

　　three

　　Symptoms and treatment after plague infection

　　People infected with plague have different symptoms according to different types. The common characteristics of plague patients are rapid onset, repeated high fever, chills, shortness of breath, rapid heartbeat and severe headache. The symptoms of bubonic plague are mainly swelling and pain of lymph nodes, mainly groin, armpit and neck, which are generally unilateral swelling and pain. Patients dare not move easily when the pain is severe. The bubonic plague may be misdiagnosed as other causes of lymph node swelling and pain, such as acute lymphadenitis, lymphadenopathy caused by filariasis, tuberculosis of lymph nodes, etc., but other diseases with lymphadenopathy usually start slowly and develop less rapidly than bubonic plague.

　　Pneumonic plague is characterized by severe chest pain, cough, expectoration, hemoptysis, dyspnea and wheezing. Pneumonic plague is easily misdiagnosed as common bacterial pneumonia or viral pneumonia, so it needs to be distinguished from other pulmonary infection diseases, including lobar pneumonia, pneumonia secondary to influenza, novel coronavirus and so on.

　　Septic plague can be characterized by high fever, no increase in body temperature, unconsciousness, confusion and even coma, extensive bleeding, ecchymosis, cyanosis and necrosis of the skin, and some patients’ bodies are purple and black after death. Septic plague is easily misdiagnosed as coma and shock caused by other reasons, such as hemorrhagic fever with renal syndrome, septicemia caused by epidemic cerebrospinal meningitis, epidemic Japanese encephalitis spread by mosquito bites, shock caused by staphylococcus aureus or streptococcus infection, etc.

　　After people are infected with plague, the disease can be effectively controlled through timely drug treatment. At present, the treatment of plague is mainly antibacterial treatment, supplemented by symptomatic support treatment. Antibacterial treatment refers to the use of antibiotics to sterilize. Streptomycin is the most effective antibiotic against Yersinia pestis, especially in the treatment of pneumonic plague, mainly by intramuscular injection, which can be injected continuously for 10 days. Gentamicin can also be used in the case of human infection with plague. Tetracycline has bacteriostatic effect, which is effective for mild patients. It can be taken orally or used together with other antibiotics. Sulfonamides are widely used in the treatment and prevention of plague. Sulfonamides are the earliest synthetic antibacterial drugs, which have good curative effect on plague, and they are easy to use, stable in nature and low in price. Symptomatic support therapy refers to helping patients recover as soon as possible by means of antipyretic analgesia, anti-shock, respiratory support and nutritional support.

　　four

　　What should I do if I find a mouse at home?

　　Domestic hamsters and rabbits usually don’t have access to wild animals, and animals don’t naturally carry infectious diseases. Without the source of infection, they won’t be infected, so there is no need to worry about domestic hamsters and rabbits catching plague. However, rats, rabbits and other animals do have a lot of bacteria in their mouths. After being bitten, it is necessary to disinfect the wound in time to avoid bacterial infection. If the wound shows signs of infection such as redness, swelling, pain and skin color change, you need to seek medical attention in time.

　　Families find that rats need to be scientifically killed. The first is to clean up the dead corners and garbage in time to reduce the living space of rats. Secondly, try to block all the passages that mice may enter and leave the room, such as air-conditioning pipe holes and sewer holes, so that mice have nowhere to hide and can’t enter the room. Around houses, corridors and other areas, compliant rat traps, rat boards and rat poison can be placed in places where rats are infested, and eye-catching signs should be made at the same time to prevent others, especially children, from accidentally contacting rat poison.

　　Don’t put snacks in the house at will. The food and all kinds of food in the house should be stored out of the reach of mice. If conditions permit, community managers should invite professional rodent control companies to carry out rodent control in a unified way to improve efficiency. If you find dead rats at home, don’t touch them with your bare hands to avoid being bitten by rats and fleas. You can wear long trousers, masks and gloves, collect the dead rats in sealed plastic bags, and contact the community property management department to dispose of the dead animals.

　　Plague prevention includes bubonic plague prevention and pneumonic plague prevention. The bubonic plague is mainly caused by the bites of rats and fleas on animals, so the prevention of bubonic plague by ordinary people is mainly to avoid contact with animals in the natural focus of plague, and to prevent rats and fleas. If you must enter the epidemic area, you can wear long trousers, boots and gloves, and try not to expose your skin to avoid being bitten by rats and fleas.

　　During the tour, everyone should try not to touch wild animals, including wild animal carcasses. Don’t buy wild animals. If you find dead animals on the roadside, you should report them to the local health and disease control departments in time.

　　If you are just traveling, you can do these preventive measures well, and you don’t need to use drugs in advance to prevent it. If you are bitten by rat fleas in areas with plague, or have close contact with patients with pneumonic plague without protection, you can use tetracycline, doxycycline, sulfanilamide and other drugs to prevent it. (Author: Deputy Chief Physician, Department 2, Infection Center, Beijing You ‘an Hospital)

Beijing Zhengban Fa [2005] No.59

The people’s governments of the districts and counties, the commissions, offices and bureaus of the municipal government, and the municipal institutions:

　　"Beijing highly pathogenic avian influenza emergency plan" has been approved by the municipal government and is hereby issued to you, please implement it carefully.

　　November 22nd, 2005

Emergency plan for highly pathogenic avian influenza in Beijing

(Revised in 2005)

catalogue

　1 General rules

　　1.1 Purpose of compilation

　　1.2 Compilation basis

　　1.3 Scope of application

　　1.4 working principles

　　1.5 epidemic situation confirmation

　　1.6 epidemic classification

2 Organization and responsibilities

　　2.1 emergency command organization

　　2.2 Daily management organization

　　2.3 Expert Advisory Group

　　2.4 Emergency handling institutions

　　2.5 Responsibilities of District and County Governments

3 Early warning and reporting

　　3.1 Early warning level

　　3.2 Early warning release

　　3.3 Early warning response

　　3.4 epidemic situation report　

　4 emergency response

　　4.1 the principle of emergency response

　　4.2 Graded response

　　4.3 Basic emergency

　　4.4 Expand emergency response

　　4.5 Emergency response in areas without epidemic situation

　　4.6 Safety Protection of Emergency Handling Personnel

　　4.7 Termination of emergency response

　5 after-treatment

　　5.1 Late evaluation

　　5.2 Reward

　　5.3 Responsibility

　　5.4 Disaster compensation

　　5.5 Pensions and subsidies

　　5.6 Resume production

　　5.7 Social assistance

　6. Guarantee of emergency response

　　6.1 Technical Support of Command System

　　6.2 Communication Guarantee

　　6.3 Emergency resources and equipment support

　　6.4 Technical Reserve and Guarantee

　7 Training, exercises and publicity and education

　　7.1 Training

　　7.2 exercise

　　7.3 publicity and education

　8 supplementary provisions

　　8.1 Definitions and descriptions of noun terms and abbreviations

　　8.2 Plan Management and Update

　　8.3 Plan Interpretation Department

　　8.4 implementation time of the plan

　　1 General rules

　　1.1 Purpose of compilation

　　Through the preparation and implementation of this plan, we will earnestly strengthen the basic work of emergency treatment of highly pathogenic avian influenza, build a long-term management and emergency treatment mechanism that combines prevention and extermination, realize systematic prevention, scientific decision-making, intelligent command and overall security, ensure that administrative and technical resources can be mobilized in time when a highly pathogenic avian influenza epidemic occurs, and take strict measures to effectively control and exterminate the epidemic, so as to minimize the losses caused by the epidemic.

　　1.2 Compilation basis

　　This plan is formulated in accordance with People’s Republic of China (PRC) Animal Epidemic Prevention Law, People’s Republic of China (PRC) Entry-Exit Animal and Plant Quarantine Law, Emergency Regulations on Major Animal Epidemic, National Emergency Plan for Sudden Major Animal Epidemic, National Emergency Plan for Highly Pathogenic Avian Influenza, Measures for Beijing to Implement People’s Republic of China (PRC) Animal Epidemic Prevention Law, Beijing Overall Emergency Plan for Public Emergencies and related regulations.

　　1.3 Scope of application

　　This plan is applicable to the emergency treatment of highly pathogenic avian influenza epidemic that has caused or may cause serious losses in poultry production and serious damage to public health.

　　The management object of this plan is the poultry and its products produced, slaughtered, transported, stored, imported and sold in this city, the poultry used for viewing, performing arts, competitions, scientific research and teaching, diagnosis and treatment, and wild poultry such as migratory birds.

　　1.4 working principles

　　1.4.1 Territorial management

　　Governments at all levels shall uniformly lead and direct the emergency handling of highly pathogenic avian influenza epidemic; Territorial management shall be implemented for emergency handling of epidemic situation; Governments at all levels are responsible for extinguishing the epidemic situation of highly pathogenic avian influenza within their respective administrative areas, and all relevant departments shall, in accordance with the provisions of the plan, do a good job in emergency handling of the epidemic situation within their respective functions and duties. According to the scope, nature and degree of harm of highly pathogenic avian influenza epidemic, the epidemic situation shall be managed at different levels.

　　1.4.2 Rapid response

　　Governments at all levels shall, in accordance with relevant laws and regulations, establish and improve the emergency system, emergency response mechanism and emergency handling procedures for highly pathogenic avian influenza epidemic, and improve the emergency handling capacity for highly pathogenic avian influenza epidemic; When a highly pathogenic avian influenza epidemic occurs, governments at all levels should respond quickly and take decisive measures to control and extinguish the epidemic in time.

　　1.4.3 Prevention first.

　　Carry out the policy of putting prevention first, implement various prevention and control measures, do a good job in emergency reserve of personnel, technology, materials and equipment, and carry out technical training and emergency drills on a regular basis as needed; Carry out epidemic monitoring, early warning and forecasting, and timely analyze and warn all kinds of situations that may lead to highly pathogenic avian influenza epidemic, so as to achieve early detection, quick action and strict handling.

　　1.4.4 Scientific control

　　Implement scientific prevention and control, further establish and popularize scientific immunization and disinfection procedures, strengthen epidemiological research, standardize the operating procedures of epidemic prevention and quarantine, and realize scientific and standardized prevention and control work.

　　1.4.5 Group prevention and control

　　Strengthen the propaganda of epidemic prevention knowledge, popularize the epidemic prevention knowledge of highly pathogenic avian influenza, popularize immunization, diagnosis and disinfection techniques, improve the epidemic prevention awareness and self-protection awareness of animal breeding practitioners and the general public, and enhance the awareness of the whole society to prevent highly pathogenic avian influenza; The emergency treatment of highly pathogenic avian influenza epidemic situation depends on the masses, the whole people’s epidemic prevention, and mobilization of various resources to achieve mass prevention and control.

　　1.5 epidemic situation confirmation

　　1.5.1 After receiving the epidemic report, the supervising agency for animal epidemic prevention immediately dispatched two or more epidemic prevention personnel with relevant qualifications to the site for clinical diagnosis and put forward preliminary diagnosis opinions.

　　1.5.2 In case of suspected highly pathogenic avian influenza epidemic, timely collect disease materials and send them to the Municipal Veterinary Laboratory for serological detection (waterfowl cannot use agar diffusion test). If the diagnosis is positive, it can be confirmed as a suspected case of highly pathogenic avian influenza.

　　1.5.3 Suspected cases must be sent to the laboratory designated by the animal husbandry and veterinary administrative department of the State Council for virus isolation and identification for final diagnosis.

　　1.6 epidemic classification

　　According to the nature, harm degree and scope of highly pathogenic avian influenza epidemic, the epidemic situation of highly pathogenic avian influenza is divided into four levels: particularly serious (Grade I), major (Grade II), large (Grade III) and general (Grade IV).

　　1.6.1 particularly serious and highly pathogenic avian influenza epidemic situation (Grade I)

　　Within 21 days, there were more than 4 districts and counties with epidemic situation; Or the number of epidemic spots is more than 10; Or there are more than 4 townships or more than 3 contiguous townships in one district and county; Or in several districts and counties, there are multiple trends, and some people are infected, which continues to spread in a large area.

　　1.6.2 Major highly pathogenic avian influenza epidemic (Grade II)

　　Within 21 days, there were 2 to 3 districts and counties with epidemic situation; Or there are 4 to 9 epidemic spots in one district and county; Or an epidemic occurred in two townships.

　　1.6.3 Large and highly pathogenic avian influenza epidemic (Grade III)

　　Within 21 days, there are two or three epidemic spots in one district and county.

　　1.6.4 General epidemic situation of highly pathogenic avian influenza (Grade IV)

　　Occurred in a township and an epidemic spot.

　　2 Organization and responsibilities

　　2.1 emergency command organization

　　2.1.1 Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) shall lead, organize and coordinate the emergency treatment of highly pathogenic avian influenza in the city.

　　Responsibilities of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters):

　　(1) Implement the Law of People’s Republic of China (PRC) on Animal Epidemic Prevention and the Measures of Beijing for Implementing the Law of People’s Republic of China (PRC) on Animal Epidemic Prevention and other laws and regulations;

　　(2) Organizing the formulation and revision of the Emergency Plan for Highly Pathogenic Avian Influenza in Beijing;

　　(3) To lead, organize and implement the prevention and control of highly pathogenic avian influenza in this Municipality, and formulate working procedures for the prevention and control of highly pathogenic avian influenza;

　　(4) to guide the prevention and treatment of highly pathogenic avian influenza in districts and counties.

　　2.1.2 The commander-in-chief of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) is the deputy mayor in charge, and the deputy commander-in-chief is the deputy secretary-general in charge of the municipal government and the director and deputy director in charge of the Municipal Agriculture Bureau. He is responsible for the unified leadership and unified command of the emergency treatment of highly pathogenic avian influenza epidemic and makes major decisions to deal with the highly pathogenic avian influenza epidemic.

　　2.1.3 member units and responsibilities of the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters).

　　Municipal Bureau of Agriculture: (1) Responsible for organizing and coordinating relevant departments to do a good job in the prevention and control of highly pathogenic avian influenza; (2) To undertake the work functions of the Office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), and organize and carry out the work of epidemic monitoring, immunization, culling, disinfection, disease diagnosis and reporting, epidemiological investigation and focus tracking in a unified way; (3) Put forward the technical scheme for epidemic control and extermination; (4) Delineate epidemic spots, epidemic areas and threatened areas, put forward blockade suggestions to the municipal government and participate in the organization and implementation; (5) Supervise and guide the culling of poultry in epidemic areas, carry out harmless treatment of poultry carcasses and poultry products according to the prescribed standards, disinfect and treat pollutants in epidemic areas, and disinfect breeding sites and surrounding environment; (6) Organize emergency immunization of related animals in the threatened area; (7) Monitoring related animals and animal products in the threatened area; (8) Organize the establishment of emergency epidemic prevention materials storage, and reserve enough vaccines, diagnostic reagents, disinfection drugs, machines and tools, equipment, protective articles, blockade facilities and harmless treatment facilities; (9) To be responsible for the training of the emergency response reserve team; (10) to participate in the propaganda work of epidemic spots, epidemic areas and surrounding people.

　　Municipal Agriculture Committee: responsible for studying and putting forward policy suggestions for the development of agricultural industry.

　　Propaganda Department of the Municipal Party Committee: responsible for coordinating and organizing the news propaganda work of highly pathogenic avian influenza and popularizing relevant scientific prevention and control knowledge.

　　Municipal government supervision room: responsible for supervising the prevention and control of highly pathogenic avian influenza in all districts and counties and relevant departments.

　　Legislative Affairs Office of the municipal government: responsible for organizing the formulation of policies, regulations and compulsory measures for the prevention and control of highly pathogenic avian influenza.

　　Municipal Information Office: responsible for the construction of information network for the prevention and control of highly pathogenic avian influenza, do a good job in network maintenance and ensure the safety and smoothness of the network.

　　Municipal organization: responsible for the implementation of the staffing of major animal disease prevention and control institutions.

　　Foreign Affairs Office of the Municipal Government: responsible for the review and coordination of foreign-related matters concerning the prevention and control of highly pathogenic avian influenza in this Municipality, and handling matters related to foreign embassies in China, overseas news agencies in Beijing, overseas personnel in Beijing, Hong Kong and Macao Beijing offices and personnel.

　　Municipal Health Bureau: responsible for prevention, medical observation and human epidemic monitoring of high-risk groups, and strengthening contact and information communication with animal epidemic prevention departments.

　　Municipal Development and Reform Commission: responsible for making plans and arrangements for infrastructure construction related to epidemic prevention and control.

　　Municipal Finance Bureau: responsible for ensuring the funds needed for emergency treatment of epidemic diseases such as immunization, monitoring, disinfection, culling and harmless treatment, and strengthening supervision over the use of funds.

　　Beijing Entry-Exit Inspection and Quarantine Bureau: Strengthen the quarantine of inbound and outbound animals, animal products and other quarantine objects to prevent the spread of epidemic diseases.

　　Municipal Public Security Bureau: responsible for assisting relevant departments to do a good job in blockade and forced culling of epidemic areas, and to do a good job in security and social security management of epidemic areas.

　　Municipal Administration for Industry and Commerce: It is responsible for closing the poultry and poultry products trading market in epidemic areas and cracking down on the illegal operation of poultry and poultry products in the market.

　　City Urban Management and Law Enforcement Bureau: responsible for cracking down on the illegal operation of poultry and poultry products outside the bazaar according to law.

　　Municipal Transportation Commission: Cooperate with epidemic prevention and control, and be responsible for giving priority to the dispatch of emergency epidemic prevention materials.

　　Municipal Science and Technology Commission: responsible for strengthening the research on early warning and forecasting of epidemic situation and prevention and control technology.

　　Municipal Bureau of Commerce: responsible for strengthening market monitoring and management of reserved poultry products, organizing market regulation and maintaining market stability.

　　Municipal Management Committee: responsible for coordinating the relevant units to do a good job in the collection and harmless treatment of kitchen waste.

　　Municipal Forestry Bureau: It is responsible for cracking down on illegal hunting and management of wild birds, closely monitoring the health status of wild birds, and immediately notifying the local supervising agencies for animal epidemic prevention when any abnormality is found, and assisting the animal husbandry and veterinary departments in monitoring relevant diseases.

　　Municipal Water Affairs Bureau: responsible for the observation of aquatic wild birds in water source protection areas and surrounding areas, and immediately notify the local supervising agencies for animal epidemic prevention when any abnormality is found, and assist the animal husbandry and veterinary departments to do a good job in disease monitoring.

　　Municipal Bureau of Landscape Architecture: responsible for coordinating the immunization of birds in parks under the guidance of animal quarantine departments and health and epidemic prevention departments at the county level, closely monitoring their health conditions, immediately notifying the local supervising agencies for animal epidemic prevention when finding any abnormality, and cooperating with the animal husbandry and veterinary departments to do a good job in monitoring the epidemic situation.

　　Municipal Bureau of Quality and Technical Supervision: responsible for strengthening the supervision of poultry products production and processing enterprises.

　　Logistics Department of Beijing Garrison: responsible for the prevention and control of epidemic diseases in its subordinate units, actively cooperating with the prevention and control of epidemic diseases in the station, and timely reporting epidemic information.

　　Municipal Local Taxation Bureau: It is responsible for regulating and controlling the taxation of poultry farms (households) affected by the disaster, and promoting them to resume production as soon as possible.

　　Civil Affairs Bureau: responsible for providing life assistance to poultry farm personnel and poultry farmers who have difficulties in living due to disasters, and properly arranging the basic life of the affected people.

　　Municipal Tourism Bureau: responsible for cooperating with the Municipal Agriculture Bureau to carry out epidemic prevention supervision and management of hotels and restaurants.

　　Beijing Railway Bureau: Ensure the transportation of emergency personnel dealing with highly pathogenic avian influenza, emergency materials and relevant samples such as prevention and control drugs and instruments, and ensure safety and speed; Cooperate with the supervising agencies for animal epidemic prevention to do a good job in quarantine supervision of poultry and their products transported by rail.

　　Civil Aviation North China Regional Administration: organize and coordinate relevant units to do a good job in air transportation support for emergency personnel dealing with highly pathogenic avian influenza epidemic situation, emergency materials such as prevention and control drugs and equipment, and related samples; Supervise the relevant units to cooperate with the supervising agencies for animal epidemic prevention to do a good job in quarantine supervision of poultry and their products transported by air, and cooperate with the inspection and quarantine departments to do a good job in inspection and quarantine of inbound and outbound poultry and their products.

　　Beijing Ershang Group Co., Ltd.: Responsible for the reserve of national and municipal commodities and ensuring the quality of the reserved commodities.

　　Beijing Dafa Animal Products Company: responsible for the animal epidemic prevention work of this enterprise.

　　Beijing Huadu Group Co., Ltd.: Responsible for the animal epidemic prevention work of this enterprise.

　　Beijing Sanyuan Group Co., Ltd.: Responsible for the animal epidemic prevention work of this enterprise.

　　2.2 Daily management organization

　　The municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) has an office as a daily office. The office is located in the Municipal Agriculture Bureau. The office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) is equipped with a command site and corresponding facilities and equipment as a command platform when a major animal epidemic occurs, and it is interconnected with the command platform of the Municipal Emergency Committee.

　　The functions of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) Office for the prevention and control of highly pathogenic avian influenza are as follows:

　　(1) Responsible for organizing the implementation of the decision of the Municipal Emergency Committee and the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), mobilizing the reserve team for emergency treatment of highly pathogenic avian influenza epidemic, coordinating the member units of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), and contacting the municipal expert advisory group.

　　(2) Responsible for organizing the drafting and revision of the Emergency Plan for Highly Pathogenic Avian Influenza in Beijing, organizing emergency drills for highly pathogenic avian influenza incidents, and organizing publicity, education and training for the prevention and treatment of highly pathogenic avian influenza.

　　(3) Responsible for the collection, analysis and reporting of highly pathogenic avian influenza information at home and abroad.

　　(4) responsible for organizing the investigation of hidden dangers of highly pathogenic avian influenza in the city.

　　(5) Responsible for issuing blue and yellow warning information, and put forward suggestions on issuing orange and red warning information to the office of the Municipal Emergency Committee.

　　(6) responsible for the construction of the city’s highly pathogenic avian influenza emergency command system and the management of emergency resources.

　　(7) coordinate and deal with the problems encountered in the prevention and treatment of highly pathogenic avian influenza.

　　2.3 Expert Advisory Group

　　City headquarters for the prevention and control of major animal diseases (emergency headquarters, a major animal disease) hired experts to form a highly pathogenic avian influenza expert advisory group.

　　Main responsibilities:

　　(1) to put forward suggestions on technical measures to deal with the corresponding level of highly pathogenic avian influenza epidemic;

　　(2) Make suggestions on emergency preparedness for highly pathogenic avian influenza epidemic;

　　(3) to participate in the formulation or revision of emergency plans and disposal technical schemes for highly pathogenic avian influenza;

　　(4) to provide technical guidance and training for emergency treatment of highly pathogenic avian influenza epidemic;

　　(5) Put forward suggestions on termination and post-evaluation of emergency response to highly pathogenic avian influenza epidemic;

　　(6) To undertake other tasks assigned by the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) and the Office.

　　2.4 Emergency handling institutions

　　2.4.1 Field headquarters

　　The on-site headquarters is responsible for organizing the implementation of the decision of the Municipal Emergency Committee and the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), and coordinating and mobilizing the member units of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) to jointly carry out the emergency treatment of highly pathogenic avian influenza epidemic.

　　2.4.2 Reserve Team for Emergency Treatment of Highly Pathogenic Avian Influenza

　　Key personnel in animal husbandry and veterinary administration, animal epidemic prevention supervision, health and epidemic prevention, public security and other aspects are drawn from relevant departments and units of the city and county to form an emergency response reserve team, and epidemic situation handling, public security blockade, emergency immunization and health and epidemic prevention teams are set up separately, and each team is composed of corresponding professionals. Its main duties are to blockade the epidemic areas, cull susceptible poultry in the epidemic areas, strictly disinfect the epidemic areas and do a good job in personnel protection according to the requirements of emergency command agencies for major animal epidemics at all levels and the specific scope of designated epidemic areas and threatened areas.

　　2.5 Responsibilities of District and County Governments

　　The district and county governments shall take overall responsibility for the prevention and control of highly pathogenic avian influenza within their respective jurisdictions. According to the contents of this plan, formulate the planning, monitoring plan and emergency plan for the prevention and control of highly pathogenic avian influenza in this area; Establish an emergency command system and daily offices for major animal epidemics in districts and counties, uniformly lead and direct the emergency handling of highly pathogenic avian influenza epidemic within their respective administrative areas, make decisions on handling highly pathogenic avian influenza epidemic within their respective administrative areas, and decide on measures to be taken.

　　3 Early warning and reporting

　　3.1 Early warning level

　　According to the possible harm degree, development and urgency of highly pathogenic avian influenza epidemic, it is divided into four warning levels from low to high: general (level IV), severe (level III), severe (level II) and particularly severe (level I), which are indicated by blue, yellow, orange and red in turn.

　　Blue Warning: Outbreaks of highly pathogenic avian influenza with neighboring countries or other provinces, autonomous regions and municipalities (except Inner Mongolia Autonomous Region, Liaoning Province, Shandong Province, Henan Province, Shanxi Province, Hebei Province and Tianjin City).

　　Yellow warning: The outbreak of highly pathogenic avian influenza in Inner Mongolia Autonomous Region, Liaoning Province, Shandong Province, Henan Province and Shanxi Province has a tendency to spread to this city.

　　Orange warning: Highly pathogenic avian influenza has broken out in Hebei Province and Tianjin, and it has a tendency to spread to this city.

　　Red warning: A suspected case of highly pathogenic avian influenza occurred in this city, or a suspected case of human infection with highly pathogenic avian influenza appeared.

　　3.2 Early warning release

　　3.2.1 According to the monitoring information provided by the supervising agency for animal epidemic prevention and the epidemic dynamics of highly pathogenic avian influenza at home and abroad, the office of the municipal headquarters for the prevention and control of major animal epidemics (emergency headquarters) analyzes the harm degree and development trend according to the occurrence, development law and characteristics of highly pathogenic avian influenza epidemic, puts forward corresponding early warning suggestions, and releases them after being approved by the municipal headquarters for the prevention and control of major animal epidemics (emergency headquarters) and the municipal emergency committee.

　　3.2.2 After confirming the early warning information that may cause highly pathogenic avian influenza epidemic, the Municipal Command for Prevention and Control of Major Animal Diseases (emergency headquarters) shall deploy in time according to the formulated plan, and promptly notify all relevant departments and units to take action to prevent the occurrence and spread of highly pathogenic avian influenza epidemic.

　　3.2.3 In accordance with the relevant provisions on the release and confidentiality of the epidemic situation, early warning of highly pathogenic avian influenza with different levels shall be released and cancelled. General and heavier level of early warning, by the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) organization issued and announced the cancellation. Serious and especially serious warning information needs to be reported to the main leaders of the city for approval, and the office of the Municipal Emergency Committee is responsible for organizing the release and announcement of cancellation.

　　3.3 Early warning response

　　3.3.1 Blue Early Warning Response

　　Pay close attention to the development trend of epidemic situation in neighboring countries or relevant provinces, autonomous regions and municipalities. Strengthen the reserve of epidemic prevention materials such as vaccines and disinfectants. Strengthen the monitoring of immune effect. Strengthen the observation and monitoring of transit migratory birds. It is forbidden to import birds and their products from countries and regions in epidemic areas announced by the Ministry of Agriculture and the General Administration of Quality Supervision, Inspection and Quarantine, and strengthen the quarantine of imported birds and their products in non-epidemic areas. After the epidemic situation in neighboring countries or relevant provinces, autonomous regions and municipalities is controlled, the blue warning will be cancelled.

　　3.3.2 Yellow Early Warning Response

　　On the basis of implementing the blue warning response measures, all poultry farms (households) should adopt closed feeding methods to strictly control the flow of people and logistics. Expand the monitoring scope of poultry immune effect, and timely supplement the poultry farms (households) with low immune titer. Thoroughly disinfect the internal and external environment of poultry farms (households). In addition to the live birds from the breeding bases outside Beijing designated by this Municipality entering Beijing according to the relevant procedures, other live birds from other places will be stopped from entering Beijing. Suspend the city’s live poultry trading activities, suspend the release of pigeons and temporarily close the bird trading market. Strictly inspect and quarantine poultry and products entering Beijing through roads, railways, civil aviation and other channels according to law. Combine neighboring provinces and cities to carry out compulsory immunization of poultry within 5 kilometers from both sides of the administrative boundary of this Municipality, and establish a "firewall" for the prevention and control of highly pathogenic avian influenza in this Municipality; Carry out dragnet inspection, strengthen the monitoring of the immune effect of poultry within 5 kilometers from both sides of the administrative boundary of this Municipality, and make up for the exemption in time when problems are found. All members of the emergency command organization for major animal diseases strengthen information communication and jointly strengthen various prevention and control measures. After the epidemic situation in relevant provinces, autonomous regions and municipalities is effectively controlled, the yellow warning will be cancelled.

　　3.3.3 Orange Early Warning Response

　　On the basis of implementing the yellow early warning response measures, stop foreign poultry and their products from entering Beijing. When necessary, purchase poultry within 3 kilometers of the border between this city and the epidemic area. Strengthen joint prevention and control with Hebei Province and Tianjin City, and establish an information notification mechanism to ensure timely and effective communication of information. After the epidemic situation in Hebei Province and Tianjin City was effectively controlled, the orange warning was cancelled.

　　3.3.4 Red Warning Response

　　On the basis of implementing the orange early warning and response measures, the relevant departments closed the area where suspected cases occurred, and implemented measures such as culling and compulsory immunization for poultry in this area and surrounding areas. Isolate people suspected of being infected with highly pathogenic avian influenza and their close contacts. The Municipal Agriculture Bureau and the Municipal Health Bureau strengthen information communication and jointly strengthen various prevention and control measures. If suspected cases are excluded, cancel the red warning; If the epidemic situation is confirmed, enter the emergency response procedure.

　　3.4 epidemic situation report

　　Any unit or individual has the right to report the epidemic situation of highly pathogenic avian influenza and its hidden dangers to governments at all levels and relevant departments, and to report the departments, units and individuals that fail to perform or fail to perform the duties of emergency handling of highly pathogenic avian influenza epidemic in accordance with regulations to higher government departments.

　　3.4.1 Responsibility Reporting Unit and Responsibility Reporting Person

　　(1) Responsibility reporting unit

　　a。 Units related to poultry breeding and management, production and management of poultry products, various animal clinics and other related units;

　　b。 Relevant scientific research units and institutions;

　　c。 Supervising agencies for animal epidemic prevention under local governments at or above the county level;

　　d。 Other relevant departments and units.

　　(2) Responsible reporter

　　Personnel who raise and manage poultry and produce and manage poultry products; Staff of various animal clinics; Relevant staff of scientific research units and colleges; Personnel of supervising agencies for animal epidemic prevention at all levels performing their duties; Other relevant personnel.

　　3.4.2 Report Form

　　The supervising agencies for animal epidemic prevention at all levels shall report the epidemic situation of highly pathogenic avian influenza according to the relevant provisions of the state; Other responsible reporting units and individuals report by telephone or in writing.

　　3.4.3 Time limit and procedures for reporting

　　When a suspected highly pathogenic avian influenza epidemic situation is found, it must be reported to the district and county supervising agencies for animal epidemic prevention immediately. After receiving the report, the county supervising agencies for animal epidemic prevention shall immediately rush to the scene for clinical diagnosis. If necessary, please ask the municipal supervising agencies for animal epidemic prevention to send people to assist in the diagnosis. After it is identified as a suspicious epidemic situation, it shall report the epidemic situation to the municipal supervising agencies for animal epidemic prevention step by step within 2 hours, and also report it to the county emergency headquarters for major animal epidemics. The municipal supervising agency for animal epidemic prevention shall, within 1 hour after receiving the report, report to the office of the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) and the municipal veterinary administrative department. The office of the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) and the municipal veterinary administrative department shall report to the municipal government (Municipal Emergency Committee) and the Ministry of Agriculture respectively within 1 hour after receiving the report.

　　If it is identified as a suspicious epidemic situation, it shall immediately collect sick materials and send them to the laboratory of the Municipal Veterinary Laboratory for preliminary diagnosis; Confirmed as a suspected case of highly pathogenic avian influenza, sent to the National Avian Influenza Reference Laboratory for diagnosis.

　　3.4.4 Report content

　　(1) the time and place of the epidemic;

　　(2) species and quantity of infected or suspected infected animals, number of animals in the same group, immunity, number of deaths, clinical symptoms, pathological changes and diagnosis;

　　(3) Epidemiology and focus tracking;

　　(4) Control measures taken;

　　(5) the unit, person in charge, reporter and contact information of the epidemic situation report.

　　4 emergency response

　　4.1 the principle of emergency response

　　When a highly pathogenic avian influenza epidemic occurs, the municipal, district, county and township governments and their relevant departments make emergency response according to the principle of graded response. At the same time, it is necessary to follow the objective law of the occurrence and development of highly pathogenic avian influenza epidemic, and adjust the response level in time in combination with the actual situation and the needs of prevention and control work. Pay attention to the analysis of the development trend of highly pathogenic avian influenza epidemic situation, and upgrade the response level in time for the epidemic situation with expanding situation and influence; For the epidemic with limited scope and no further spread, the response level should be reduced accordingly. The emergency treatment of highly pathogenic avian influenza epidemic should adopt the methods of investigation, treatment and verification to effectively control the development of the epidemic.

　　Districts and counties where highly pathogenic avian influenza epidemic has not occurred should organize personnel, materials and other emergency preparations, take necessary preventive and control measures to prevent highly pathogenic avian influenza epidemic from occurring within their respective administrative areas, obey the unified command of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), and support the emergency treatment at the place where highly pathogenic avian influenza epidemic has occurred.

　　4.2 Graded response

　　4.2.1 Emergency response to particularly serious and highly pathogenic avian influenza epidemic (Grade I)

　　By the office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), suggestions are made to the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) and the Office of the Municipal Emergency Committee, and the emergency plan is launched after being approved by the main leaders of the municipal party committee and the municipal government. The mayor is responsible for emergency command; The deputy mayor in charge should rush to the scene, and set up an on-site headquarters composed of the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) and the local district and county governments. The mayor is the commander in chief, responsible for participating in the formulation of plans, guiding, coordinating and urging relevant departments to carry out their work; The commander-in-chief of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) and the relevant leaders of the local districts and counties shall be the executive commander-in-chief, responsible for the specific command and disposal of the epidemic.

　　When a particularly serious and highly pathogenic avian influenza epidemic occurs, the municipal government or district/county government shall issue a blockade decision according to law. The public security department and the armed police force blocked the epidemic areas and set up temporary checkpoints. The city stopped all poultry and its products from entering and leaving Beijing and closed all live poultry trading markets. If someone is infected with highly pathogenic avian influenza, the health department should treat the infected person in isolation and observe the people in contact with him in isolation. By the epidemic emergency response reserve team, poultry within a radius of 3 kilometers with the epidemic as the center will be culled, and poultry products will be treated harmlessly; The supervising agencies for animal epidemic prevention shall organize the implementation of compulsory immunization for poultry within 5 kilometers outside the epidemic area; Strictly disinfect the internal and external environment of all poultry farms (households) and strictly control the flow of people and logistics.

　　4.2.2 Emergency Response to Major Highly Pathogenic Avian Influenza Epidemic (Level II)

　　The municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) is responsible for starting the emergency plan. The deputy mayor in charge is responsible for emergency command, and the deputy secretary-general in charge assists the deputy mayor in his work. The director and deputy director of the Municipal Bureau of Agriculture should rush to the scene and set up an on-site headquarters composed of the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) and the district and county governments. The deputy mayor in charge is the chief commander, responsible for participating in the formulation of the plan and coordinating the work of relevant departments; The director of the Municipal Bureau of Agriculture, the deputy director in charge and the relevant responsible comrades of the districts and counties shall be the executive chief commander, responsible for the specific command and disposal of the incident.

　　When a major highly pathogenic avian influenza epidemic occurs, the municipal government or district/county government shall issue a blockade decision according to law. The public security department and the armed police force blocked the epidemic areas and set up temporary checkpoints. The poultry within a radius of 3 kilometers centered on the epidemic spot shall be culled by the emergency response reserve team; Birds within 5 kilometers outside the epidemic area shall be given compulsory immunization by the supervising agencies for animal epidemic prevention; Strictly disinfect the internal and external environment of all poultry farms (households) and strictly control the flow of people and logistics.

　　4.2.3 Emergency response to a large and highly pathogenic avian influenza epidemic (Grade III)

　　The office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) is responsible for starting the emergency plan and taking full command. When necessary, the person in charge of the office of the Municipal Agriculture Bureau or the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) was present to participate in the formulation of the plan and coordinate the work of relevant departments.

　　When a large highly pathogenic avian influenza epidemic occurs, the local district and county governments shall issue a blockade decision according to law. The public security department and the armed police force blocked the epidemic areas and set up temporary checkpoints. The poultry within a radius of 3 kilometers centered on the epidemic spot shall be culled by the emergency response reserve team; Poultry within 5 km outside the epidemic area shall be given compulsory immunization by the supervising agency for animal epidemic prevention. Strictly disinfect the internal and external environment of all poultry farms (households) and strictly control the flow of people and logistics.

　　4.2.4 Emergency Response of General Highly Pathogenic Avian Influenza Epidemic (Grade IV)

　　The emergency headquarters of major animal diseases in the epidemic areas and counties shall be responsible for starting the emergency plan and handling it with full authority. When necessary, the office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) sent technicians to the site to give guidance and support.

　　When a general highly pathogenic avian influenza epidemic occurs, the local district and county governments shall issue a blockade decision according to law. The public security department and the armed police force blocked the epidemic areas and set up temporary checkpoints. The poultry within a radius of 3 kilometers centered on the epidemic spot shall be culled by the emergency response reserve team; Birds within 5 kilometers outside the epidemic area shall be given compulsory immunization by the supervising agencies for animal epidemic prevention; Strictly disinfect the internal and external environment of all poultry farms (households) and strictly control the flow of people and logistics.

　　4.3 Basic emergency

　　Under the unified leadership and command of governments at all levels and close cooperation with relevant departments, emergency treatment of highly pathogenic avian influenza epidemic situation will be carried out.

　　(1) according to the needs of highly pathogenic avian influenza epidemic, mobilize all kinds of personnel, materials, transportation and related facilities and equipment to carry out emergency treatment.

　　(2) Issue a blockade order to blockade the epidemic areas. If the blockade of epidemic areas exceeds the area under its jurisdiction, and the blockade of epidemic areas leads to the interruption of trunk traffic, it shall be reported to the government at the next higher level for approval and release the blockade decision according to regulations.

　　(3) Organize supervising agencies for animal epidemic prevention to investigate and deal with the epidemic situation of highly pathogenic avian influenza; Delineate epidemic spots, epidemic areas and threatened areas, and propose and implement targeted prevention and control measures; According to the provisions of the collection of disease materials, sent to the city veterinary laboratory for testing, such as confirmed as suspected cases, sent to the National Avian Influenza Reference Laboratory for diagnosis.

　　(4) Organize emergency preparedness teams to temporarily requisition houses, places and vehicles, take emergency measures such as culling infected animals and related animals, sealing public drinking water sources contaminated by highly pathogenic avian influenza pathogens, and organize emergency immunization as needed.

　　(5) Take measures to restrict or stop the trade of poultry and poultry products according to the epidemic level.

　　(6) Organize public security, transportation and other departments to set up temporary animal epidemic prevention supervision and inspection stations at traffic stations according to law to inspect and disinfect vehicles.

　　(7) Organize township governments, sub-district offices, neighborhood committees and village committees to carry out mass prevention and control.

　　(8) Organize relevant departments to ensure the supply of commodities, stabilize prices, severely crack down on illegal and criminal activities such as spreading rumors and spreading rumors, making and selling fake goods and disturbing social order, and maintain social stability.

　　(9) Responsible for the supervision and inspection of emergency handling.

　　(10) In accordance with the provisions of the state, timely carry out training on relevant technical standards and norms.

　　(11) to carry out targeted publicity and education on epidemic prevention knowledge of highly pathogenic avian influenza, and improve people’s awareness of prevention and control and self-protection ability.

　　(12) Organize experts to comprehensively evaluate the handling of highly pathogenic avian influenza epidemic situation, including the epidemic situation, on-site investigation, tracking of epidemic sources, and measures such as poultry culling, harmless treatment, disinfection and emergency immunization.

　　(13) do a good job in information collection, reporting and analysis of highly pathogenic avian influenza epidemic.

　　4.4 Expand emergency response

　　(1) When an epidemic situation of highly pathogenic avian influenza involving foreign countries occurs, the Foreign Affairs Office of the municipal government, the Municipal Publicity Office and other relevant departments should send people to participate in the work of the on-site headquarters according to the needs of emergency handling and the division of responsibilities, and be responsible for undertaking related matters.

　　(2) With the existing emergency resources and manpower in this city, it is difficult to implement effective disposal, and it is necessary for the state or other provinces and cities to provide assistance and support. The Municipal Emergency Committee should immediately report the situation to the CPC Central Committee and the State Council, request the CPC Central Committee and the State Council to directly direct or authorize Beijing to direct, coordinate and mobilize the emergency resources of the central state units in Beijing, the Beijing Military Region, the Beijing Armed Police Corps and other aspects to participate in the handling of the epidemic.

　　4.5 Emergency response in areas without epidemic situation

　　According to the epidemic nature, characteristics, occurrence area and development trend of highly pathogenic avian influenza epidemic area, analyze the possibility and degree of being affected in this area, and focus on the following work:

　　(1) Keep close contact with the epidemic area and obtain relevant information in time.

　　(2) Organize the preparation of personnel and materials needed for emergency treatment in this administrative area.

　　(3) to carry out monitoring and prevention and control of highly pathogenic avian influenza in breeding, transportation, slaughter and circulation to prevent the introduction, occurrence and spread of highly pathogenic avian influenza.

　　(4) to carry out epidemic prevention knowledge propaganda of highly pathogenic avian influenza, and improve public protection ability and awareness.

　　(5) do a good job in quarantine supervision of highway, railway, aviation and water transportation according to regulations.

　　4.6 Safety Protection of Emergency Handling Personnel

　　It is necessary to ensure the safety of personnel involved in the emergency response to the epidemic. Emergency personnel should take special protective measures, such as wearing protective clothing, inoculating corresponding vaccines, and conducting serological tests regularly.

　　4.7 Termination of emergency response

　　The termination of the emergency response of highly pathogenic avian influenza epidemic situation must meet the following conditions: after all poultry and their products in the epidemic area are treated according to regulations, there are no new cases of the epidemic in at least one longest incubation period.

　　Especially serious and highly pathogenic avian influenza epidemic situation shall be evaluated by relevant experts organized by the municipal animal husbandry and veterinary administrative department, and suggestions for terminating emergency response shall be put forward, submitted to the municipal government for approval, and reported to the Ministry of Agriculture.

　　The larger and generally highly pathogenic avian influenza epidemic situation shall be evaluated by the county animal husbandry and veterinary administrative department to organize relevant experts to control the epidemic situation, put forward suggestions to terminate the emergency response, report to the county government for approval, and report to the municipal headquarters for the prevention and control of major animal epidemics (emergency headquarters) and the municipal emergency committee office.

　　5 after-treatment

　　5.1 Late evaluation

　　After the highly pathogenic avian influenza epidemic is extinguished, the emergency command institutions of major animal diseases at all levels shall organize relevant personnel to evaluate the handling of the epidemic. The contents of the assessment should include: the basic situation of the epidemic, the process of the epidemic, the results of field investigation and laboratory testing; Analysis and conclusion of the main causes of the epidemic; The process of handling the epidemic situation, the preventive measures taken and their effects; The problems and difficulties in the emergency process, as well as the reasons for the outbreak of this epidemic, the problems and difficulties in prevention and control work, etc., put forward improvement suggestions and countermeasures.

　　The assessment report shall be submitted to the government at the corresponding level (emergency committee) within 20 days, and a copy shall be sent to the emergency command organization of major animal diseases at the next higher level.

　　5.2 Reward

　　The municipal or district/county government shall commend the advanced collectives and individuals who have contributed to the emergency treatment of highly pathogenic avian influenza epidemic; Those who died heroically in the emergency treatment of highly pathogenic avian influenza epidemic situation shall be regarded as martyrs according to relevant regulations.

　　5.3 Responsibility

　　In the process of prevention, reporting, investigation, control and treatment of highly pathogenic avian influenza epidemic, there are dereliction of duty, dereliction of duty and other violations of law and discipline, and the responsibility of the parties concerned shall be investigated according to relevant laws and regulations.

　　5.4 Disaster compensation

　　In accordance with the relevant provisions of this Municipality on the management of special funds for compulsory animal culling compensation, the amount and grade standards shall be determined, and compensation shall be made according to the procedures. The object of compensation is the units and individuals whose poultry or property have suffered losses in order to put out the epidemic or prevent its spread.

　　5.5 Pensions and subsidies

　　Governments at all levels should organize relevant departments to give corresponding subsidies and pensions to those who are sick, disabled or killed due to their participation in emergency response work in accordance with relevant state regulations.

　　5.6 Resume production

　　After the highly pathogenic avian influenza epidemic is extinguished, restrictive measures such as blockade restrictions and circulation control will be cancelled. According to the characteristics of highly pathogenic avian influenza epidemic situation, the epidemic spots and epidemic areas should be continuously monitored, and animals can be reintroduced to resume poultry production if they meet the requirements.

　　5.7 Social assistance

　　After the outbreak of highly pathogenic avian influenza, the competent civil affairs departments at all levels should do a good job in the reception, distribution and use of relief materials and funds provided by all sectors of society to the epidemic areas in accordance with the People’s Republic of China (PRC) Public Welfare Donation Law, the Interim Measures for the Administration of Disaster Relief Donation and relevant state policies.

　　6. Guarantee of emergency response to epidemic situation

　　After the outbreak of highly pathogenic avian influenza, governments at all levels should actively coordinate with veterinary, health, finance, transportation, public security, industry and commerce, urban management, quality and technical supervision, forestry and other departments to do a good job in emergency support for epidemic handling.

　　6.1 Technical Support of Command System

　　6.1.1 The Office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) shall improve the technical support system for emergency command to meet the command requirements for handling the highly pathogenic avian influenza epidemic. It mainly includes: wired communication system, wireless command and dispatch system, information reporting system, basic geographic information system, analysis and decision support system, video conference system, mobile command system, etc.

　　6.1.2 The Office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) and all districts and counties shall gradually establish and improve the basic information database of emergency command. The basic information database of emergency command includes epidemic monitoring and early warning database, emergency plan database based on spatial location, emergency decision-making consulting expert database, and auxiliary decision-making knowledge database, etc. It should be maintained and updated in time to ensure the quality of data and provide support for emergency command, analysis and decision-making of highly pathogenic avian influenza.

　　6.2 Communication Guarantee

　　Under the leadership of the Municipal Emergency Committee Office and the cooperation of the Municipal Information Office and the Municipal Communications Administration, a four-level network transmission system covering cities, districts, counties, streets (towns) and communities (villages) will be formed through various telecom operators in this city, Beijing wired government private network and wireless government private network, and a stable and reliable emergency communication system with multi-routing, wire and wireless will be established. When the communication trunk line is interrupted or the existing network is blind, the communication means such as satellite and microwave are used to ensure the contact between the office of the Municipal Emergency Committee and the municipal headquarters for the prevention and control of major animal diseases (emergency headquarters) and the on-site headquarters.

　　6.3 Emergency resources and equipment support

　　6.3.1 The emergency team ensures that the municipal, district and county governments should establish a reserve team for emergency treatment of highly pathogenic avian influenza epidemic, and specifically implement culling, disinfection and harmless treatment. The reserve team consists of personnel from veterinary, health, public security, industry and commerce, armed police, military and other departments, and is relatively fixed.

　　6.3.2 Transportation Guarantee The transportation department should give priority to the dispatch of emergency epidemic prevention materials.

　　6.3.3 The health department of medical and health security is responsible for carrying out human monitoring of highly pathogenic avian influenza and doing a good job in prevention and security. Veterinary administrative departments and health departments at all levels should inform each other of the epidemic situation in a timely manner and work together.

　　6.3.4 Public security departments and armed police forces should assist in the blockade and forced culling of epidemic areas, and do a good job in the security and social security management of epidemic areas.

　　6.3.5 Material Guarantee Governments at all levels shall, according to the principle of graded storage, establish emergency epidemic prevention material storage, and store enough medicines, vaccines, diagnostic reagents, instruments, protective equipment, transportation and communication tools.

　　Reserve materials should be planned reasonably according to the poultry breeding quantity and disease control. Mainly includes: (1) highly pathogenic avian influenza inactivated vaccine; (2) diagnostic reagents; (3) Disinfecting drugs, including stable chlorine dioxide, peracetic acid, chlorine disinfectant, caustic soda, potassium permanganate, etc. (4) disinfection equipment, including high-pressure sterilizers, portable disinfection machines and tools, disinfection containers, etc.; (5) Protective articles, including breathable jumpsuits, latex gloves, ordinary white coats, hats, masks, waterproof shoes, safety goggles, etc. (6) Means of transport, including closed transport vehicles, trucks and special vehicles for on-site diagnosis and disinfection; (7) Sealing appliances, including high-strength environmentally-friendly sealed plastic bags and plastic sheets; (8) Communication tools, including car phones and walkie-talkies; (9) Other articles, including towels, flashlights and disposable 2ml syringes.

　　6.3.6 Funding guarantee

　　The financial departments of the municipal, district and county governments should arrange emergency funds for sudden major animal diseases in the general expenditure budget, use government reserve funds when necessary, and gradually increase the proportion of funds extraction according to the needs of urban public safety management.

　　After the outbreak of highly pathogenic avian influenza, first, adjust the internal structure of departmental budget according to the actual situation, cut departmental expenditure budget, and concentrate financial resources to deal with the epidemic; Second, with the approval of the government, the emergency special reserve fund was launched. In accordance with the principle of "emergency handling", simplify the work link, and complete the relevant procedures within 1 working day for the funding approved by the municipal government to ensure the smooth progress of the emergency handling of highly pathogenic avian influenza epidemic.

　　The funds required for immunization, emergency epidemic prevention materials reserve and epidemic monitoring every year shall be guaranteed by the governments at all levels, and the specific subsidy standards and management measures shall be jointly formulated by the agricultural department and the financial department. In the event of a highly pathogenic avian influenza epidemic, there is a gap between the actual capital demand and the budget arrangement, and the financial departments at all levels should add it to ensure the expenditure needs.

　　The financial departments at all levels should strengthen the management and supervision of the use of epidemic prevention funds while ensuring that the epidemic prevention funds are in place in time and in full.

　　6.4 Technical Reserve and Guarantee

　　Establish an expert Committee on highly pathogenic avian influenza. The expert committee is composed of technical officials, animal disease prevention experts, epidemiologists, health and epidemic prevention experts, wildlife experts, animal welfare experts, economic experts, risk assessment experts, legal experts, etc. It is responsible for consulting the strategies and methods of disease prevention and control, and participating in the planning, formulation and implementation of prevention and control technical schemes.

　　7 Training, exercises and publicity and education

　　7.1 Training Governments at all levels should organize systematic training for members of the reserve team for handling highly pathogenic avian influenza epidemic. The contents include: (1) knowledge of prevention, control and eradication of highly pathogenic avian influenza, including knowledge and skills of immunization, epidemiological investigation, diagnosis, collection and inspection of sick materials, disinfection, isolation, blockade, quarantine, culling and harmless treatment; (2) animal epidemic prevention laws and regulations; (3) Personal protection knowledge; (4) Common sense of public security and environmental protection; (5) Work coordination and cooperation with relevant requirements.

　　7.2 Exercise When there is no highly pathogenic avian influenza epidemic, the emergency headquarters of major animal diseases at the city, district and county levels should organize drills in a planned way every year to ensure the emergency response capability of the emergency response reserve team.

　　7.3 Publicity and Education Governments at all levels should organize relevant departments to widely spread the emergency knowledge of highly pathogenic avian influenza epidemic to the public through radio, film and television, newspapers, manuals and other forms, publicize the popular science knowledge of highly pathogenic avian influenza epidemic prevention, and guide the masses to treat the highly pathogenic avian influenza epidemic in a scientific way. It is necessary to give full play to the role of relevant social groups in popularizing animal epidemic prevention knowledge and popular science knowledge.

　　8 supplementary provisions

　　8.1 Definitions and descriptions of noun terms and abbreviations

　　Epidemic spot: the place where sick poultry are located. Generally refers to the poultry farm (household) where sick poultry are located or other relevant slaughter and business units.

　　Epidemic area: refers to the area with the epidemic spot as the center and within a radius of 3 kilometers. When dividing epidemic areas, we should pay attention to the local breeding environment, natural barriers (such as rivers and mountains) and traffic and other factors.

　　Threatened area: refers to the area within 5 kilometers outside the epidemic area.

　　In the expression of relevant quantities in this plan, "above" includes the number, and "below" does not include the number.

　　8.2 Plan Management and Update

　　This plan is formulated by the office of the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters), organized by the office of the Municipal Emergency Committee, reported to the Municipal Emergency Committee for the record, and approved, issued and implemented by the municipal government. The plan should be reviewed regularly, and revised in time according to the situation changes of highly pathogenic avian influenza epidemic and the problems found in the implementation. The emergency plan for highly pathogenic avian influenza formulated by all districts and counties and their relevant departments shall be reported to the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters) for the record.

　　8.3 Plan Interpretation Department

　　This plan shall be interpreted by the Municipal Command for the Prevention and Control of Major Animal Diseases (emergency headquarters).

　　8.4 implementation time of the plan

　　This plan shall be implemented as of the date of issuance, and the Notice of Beijing Municipal Bureau of Agriculture on Printing and Distributing the Emergency Plan for Highly Pathogenic Avian Influenza in Beijing (Jing Nong Zi [2004] No.2) shall be abolished at the same time.

Hot hitIn the worldIt is worthy of being a drama of Wang Fried released by CCTV during the Spring Festival. Even with the strong impact of the Winter Olympics, it can be at the climax of the plot developmentGet a good rating of 2.

With the growth of the characters, the timeline of this drama came to the 1980s. Although it lacked a lot of helplessness in the social background of the last decade, the material world was extremely rich.It has prompted people’s desire for other things, which has led to more dramatic conflicts.

The key word in the 1980s was "reform". Since it is reform, it means change. The most popular and sought-after iron rice bowl no longer exists, and all the adults are clearly married, but they have to face the distress of being laid off. Faced with such a situation,Zhou Bingkun’s personality characteristics can be particularly highlighted.It is worth talking about, because no matter from all aspects of performance, family, friendship and love, he can be called a model of a good man.

Can call him a good man,The first aspect is filial piety to parents.

My father, as an eighth-class mechanic, has been out all the year round building railways in China, leaving only their mother and son to guard the home. This little son of Zhou, who was not watched by his father, had to wait until his father came home and nodded in person to get married when his father didn’t know his relationship with "widow" Zheng Juan. For a father who has not seen each other for a long time,He gave great respect.

Filial piety is certainly not enough for a father who is away from home all the year round. His filial piety,Especially in his attitude towards his mother.. Zhou Jiaming has three children. He doesn’t behave like a spoiled little son, unlike the settings in other traditional novels. He is a "little son" who always talks sweet words. Instead, he’s like a big brother,All I care about is to let my mother live a good life.Hearing the teacher’s discussion on raising the mouth and mind, he told his mother firmly and calmly that he must do both things for her.

When the audience saw that her mother was so excited that she collapsed after a cerebral hemorrhage that she obviously became a vegetable, he didn’t give up, just tried to find someone to take care of her all over the world first. By the way,Even in today’s extremely developed modern medical conditions.And which children can wait for a full two years in a vegetative mother who is paralyzed in bed and motionless?

The second aspect is love, that is, devotion to his wife Zheng Juan.

How frustrating Zheng Juan’s past is.That is, how unacceptable it is to people around you, especially in an era like that at that time. To tell the truth, what happened to her was not at that time,Even today, it is difficult for most people to accept it.. First, I met a fraudulent marriage. In the process, I was raped by his good friend and broke a rib. Immediately after the rape, I lost my fruit. After having that person’s child, in the end, she has not yet obtained the certificate. Unmarried girls run with the ball. To put it bluntly, the appearance of Zhou Bingkun will be ridiculed by many people as "the catcher".

However, once Zhou Bingkun is identified, it will not be easily changed. He knows that Zheng Juan is a good girl, and what she has suffered is nothing but a disaster brought by fate.Regardless of Zheng Juan’s past.Treat her children as their own;Look at their present with a normal heartEven if Zheng Juan doesn’t know a few big words, he accepted them all in the past and now.Zheng Juan’s future has the greatest reliance.

What is particularly rare for female audiences is that Zhou Bingkun does what he says.Said to buy a car for Zheng Juan.Although it was a bicycle, it was also the most fashionable permanent brand 28 bicycle at that time.

Coupled with the good acting skills of Lei Jiayin and Yin Tao, they abruptly turned the drama of the Age into a film of pure desire.

The third aspect shows friendship. No matter when, where and where he is, he never forgets his friends’ old feelings.

At that time, the six gentlemen of the "Northeast Guangzi Film",For various reasons, the two people are separated from this group of former friends.. The remaining three people, who were frustrated in middle age, heard that Zhou Bingkun was about to become a full member, and they felt that Zhou Bingkun’s life would be farther and farther away from them. My heart is weak and weary through illness, and what I say is not pleasant to hear. When a person is at the lowest point, it is very likely that his inner dark side will be exposed.

At this time, a Chinese New Year dinner was arranged, and the three brothers just talked about it. Of course, they can’t be in front of Zhou Bingkun, so Zhou Bingkun doesn’t know how his friends view his increasingly smooth life. Just, coincidentally, when Zhou Bingkun walked in the door,But I heard them arguing over some trivial matters at home.. Zhou Bingkun didn’t pretend to brag and draw a pie at that time, but afterwards, he was sure that things could be done.Without saying anything, I helped two friends solve their family difficulties directly.. There is no so-called insincerity,Prove yourself directly with actions.Helping a friend solve the worst problem in front of him is a true friend.

At present, the development of the plot makes Zhou Bingkun’s personnel design perfect, and the audience who follow the drama only hope that he will not suddenly fall off the chain at the back.

Wen | Hong Kong Stock Research Society

On November 23rd, Netease Cloud Music announced the launch of the initial public offering in Hong Kong. The co-sponsors of the listing are Bank of America Securities, CICC and Credit Suisse.

According to the announcement, Netease Cloud Music will publicly issue 16 million common shares worldwide, with the offering price range of HK$ 19-220 per share, and plans to raise HK$ 3.04-3.52 billion (about RMB 2.49-2.89 billion), with an over-allotment right of no more than 15%. It is estimated that the valuation of Netease Cloud Music will be between 39.47 billion and 45.71 billion Hong Kong dollars (about 32.37 billion to 37.48 billion yuan) after listing.

According to the prospectus, Netease Cloud Music introduced Netease, Sony Music Entertainment and Orbis Investment Management Co., Ltd. as cornerstone investors, with a total subscription of 350 million US dollars (about 2.73 billion Hong Kong dollars). According to the plan, Netease Cloud Music will be officially listed on December 2nd with the code "9899.HK".

What is the valuation level of Netease Cloud Music with a stock price of HK$ 190-220?

According to the calculation of the prospectus, assuming that the over-allotment option has not been exercised, the shares raised by Netease Cloud Music in public account for 7.7% of the total issued shares. Based on the calculation of HK$ 19-220 per share, its valuation is between US$ 5.065 billion and US$ 5.87 billion when converted by exchange rate.

Netease Cloud Music reached 184 million monthly users in the first three quarters; The number of online music paying users was 27.52 million, an increase of over 93% year-on-year; The online music payment rate reached 14.9%.

In December 2018, Tencent Music landed on the New York Stock Exchange with a valuation of US$ 21.3 billion. The current market value is about US$ 12.9 billion, and the valuation of Netease Cloud Music is about 40% of Tencent Music. Judging from the number of users and financial situation; The cumulative MAU of Netease cloud music online music service and social entertainment is a quarter to a fifth of TME; And compared with TME, the revenue is about one fifth. However, compared with the market value of TME, the current valuation of Netease Cloud Music is obviously higher than its equivalent value. It shows that the capital market recognizes and values its content community.

This optimism should mainly come from Netease Cloud Music’s unique community route, original music advantages and highly sticky young users; It is optimistic about its long-term development. Recently, Xiaohongshu completed a new round of $500 million financing, with a market value of $20 billion after the investment. Community concept stocks are still promising investment targets in the capital market.

As far as community products are concerned, compared with the market value of bilibili and other content communities, the valuation of Netease Cloud Music is still in the low range. Bilibili’s monthly income in the third quarter of this year was 267 million, and its market value exceeded HK$ 200 billion. In contrast, Netease Cloud Music had a monthly income of 184 million in the first three quarters, and the highest valuation was only HK$ 45.7 billion, which was obviously underestimated.

Recently, Zhihu released its third quarter financial report, with an average monthly active users of 101.2 million and an average monthly paid members of 5.5 million. At present, the market value of Zhihu is about $4.6 billion. Netease Cloud Music’s monthly activity is about 1.8 times that of Zhihu in the same period, but its valuation is similar, which shows that its community valuation has not been fully reflected.

Due to the recent correction of China Stock Exchange, Internet community enterprises are at a low market value. When bilibili was first listed in the US in 2018, its market value was only $3.2 billion, and its share price really broke through more than two years after listing. In the long run, the valuation of Netease Cloud Music is seriously underestimated, and there is still much room for growth in the future.

Is the "first share of the music community" valuable after the copyright is not independent?

According to the prospectus, Netease Cloud Music’s revenue from 2018 to 2020 was 1.1 billion yuan, 2.3 billion yuan and 4.9 billion yuan respectively. In the first three quarters of 2021, the total revenue was 5.1 billion yuan, a year-on-year increase of 52%; Among them, online music revenue increased from 1.85 billion yuan in the same period of 2020 to 2.44 billion yuan, social entertainment and other sectors revenue increased from 1.52 billion yuan in the same period of last year to 2.67 billion yuan, online music service revenue accounted for 47.7%, social entertainment services and other income accounted for 52.3%.

From the cost side, the proportion of Netease Cloud Music content service cost to revenue has gradually decreased, and the gross loss has continued to narrow. At present, the gross profit margin has turned positive. In terms of revenue growth rate, Netease Cloud Music also far exceeds the overall level of the industry, reaching over 100% in 2019 and 2020, and still reaching 60.0% in the first half of 2021, about twice the growth rate of the industry. In the first half of 2021, the adjusted net loss of Netease Cloud Music narrowed to 500 million yuan year-on-year, and the gross profit margin increased significantly and turned positive to 0.4%.

It is worth noting that at present, most of Netease Cloud Music’s losses are caused by changes in the fair value of convertible redeemable preferred shares. After listing, this part of the loss will disappear with the completion of the share conversion (the latest one will expire on October 23, 2023) and will not lead to the outflow of cash flow.

In July this year, the exclusive copyright of music was banned. For the online music market, this means that the industry has returned to a level playing field. Affected by this, Netease Cloud Music has recently reached copyright cooperation with Modern Sky, Hong Kong Emperor Entertainment and China Record Group. Many famous artists, bands and musicians, such as Nicholas Tse, Joey Yung, Twins, New Pants, Tong Yang and Wu Tiao, have returned. According to the analysis of Western Securities, under the premise of gradually eliminating copyright monopoly in the music industry, the core competition of online music platform will focus more on ecological construction and user operation experience, and Netease Cloud Music has advantages in these aspects.

Hong Kong stock policy is favorable and frequent attention is paid to high-growth technology Internet enterprises.

This year, the global capital market continued to fluctuate, and many Internet companies decided to suspend the IPO process. Recently, however, with the stabilization of the market, the HKEx has also released a number of positive signals, including optimizing and broadening the secondary listing mechanism, and including technology Internet stocks such as Netease, JD.COM and Xinao Energy in the Hang Seng Index, so as to attract more enterprises to come to Hong Kong and return to Hong Kong for listing. Netease Cloud Music, as the first Internet company to officially launch IPO, also shows the strong endogenous motivation and development potential of the music community.

Compared with bilibili’s market value of more than 20 billion US dollars, and Xiaohongshu’s valuation of 20 billion US dollars; If Netease Cloud Music operates properly and the fundamentals continue to improve, there should be more room for growth.

After the reform of the listing system of the Stock Exchange in April 2018, attracting more relevant funds and enterprises to IPO in Hong Kong became the focus of work, and more and more Chinese stocks "returned" to Hong Kong for secondary listing. The relevant planning of the Stock Exchange shows that it will continue to develop Hong Kong into a large global and regional enterprise for major listing or secondary listing; andraise fundsTo attract global investors interested in investing in companies in the Asia-Pacific region and mainland investors seeking international investment opportunities.

Recently, Weibo also passed the hearing of Hong Kong stocks. Netease Cloud Music officially launched the IPO, and the recovery of Internet stocks in the Hong Kong stock market may have gradually occurred.

On March 6th, HarmonyOS Zhixing’s two high-profile models, the 2025 model and the official opening of the pre-sale, set off a boom in the automobile market. Among them, in 2025, the pre-sale price of the M9 for the border is 478,000 yuan, and that of the M8 for the border is 368,000 yuan. It is reported that the 2025 M9 will be listed in shock this month, and the M8 is scheduled to officially meet with consumers in April.

Wenjie M8 is positioned as "flagship SUV of family wisdom", with a wheelbase of 3105mm, which is only 5mm shorter than Wenjie M9, the same as the wheelbase, and the body size is close to it. It is available in two versions, 5-seat version and 6-seat version, to meet the travel needs of different families. Judging from the pre-sale price, the M-8 card in Wenjie fills the gap between the M-9 card and the M-9 card in Wenjie, further improves the product matrix of HarmonyOS Zhixing, and enters the high-end SUV market of new energy together with the M-9 card in 2025. In terms of power, M8 will simultaneously introduce two power forms: extended range and pure electricity. The extended range version is equipped with a range extender with a power of 1.5T and 118kW, and uses a driving motor with the front 165kW and the rear 227kW. The maximum speed is 200km/h, and its strength cannot be underestimated.

The 2025 model M9 was declared in February this year, including plug-in extended range and pure electric power, and equipped with Contemporary Amperex Technology Co., Limited ternary lithium-ion battery. This change has been upgraded in terms of intelligent driving hardware, which further enhances the intelligent driving ability and brings users a more advanced travel experience. It is worth mentioning that HarmonyOS Zhixing also provides optional original hardware upgrade scheme for the owners of the current M9 model, and at the same time, the current model will continue to upgrade the software features of OTA, so that the old car owners can also enjoy the constantly upgraded service. Externally, the 2025 model M9 adds the color of Jinrui red, which is more unique and distinguished. In terms of seats, 5-seat version and 6-seat version are available for consumers to choose freely. In addition, the new car is also equipped with ten black technologies, such as Huawei’s advanced intelligent driving, Xuanwu hard-core body, Huawei Turing platform and intelligent privacy windows, etc., to improve the performance and quality of vehicles in all directions.

After the pre-sale was opened, the market response of the two models was extremely enthusiastic. Wen Jie M9 2025 pre-sale 6 hours small order over 11000 units; The pre-sale price of the M8 started from 368,000 yuan, and the small order exceeded 21,000 units in 6 hours, and the small order exceeded 7,500 units in 1 hour after the opening of the reservation, showing consumers’ high recognition and expectation for these two new cars.

Yu Chengdong, managing director of Huawei, chairman of BG, and chairman of BU, a smart car solution, said that the launch of the M8 and the M9 in 2025 is another important layout of HarmonyOS Zhixing in the field of new energy vehicles. With the advantages of Huawei’s full-stack technology, ever-changing luxury space, all-dimensional safety and more personalized selection, these two models are expected to stand out in the highly competitive new energy vehicle market and bring consumers better and smarter travel choices.

Judging from the market competition pattern, there are relatively few participants in the 400,000-class hybrid SUV market, and the external competing products of M8 are mainly L9. According to the analysis of Ping An Securities Research Report, the expansion trend of the extended-range market is clear, and the customer M8 is expected to replicate the successful experience of the customer M9, accept the sinking market bonus of the customer M9, and become an explosion-proof vehicle of 400,000 yuan. It is estimated that the steady-state monthly sales of the customer M8 will reach about 15,000 vehicles. In the 500,000-class SUV market in 2025, with its continuous product upgrade and technical advantages, it is expected to continue the brilliant achievement of the 500,000-class sales champion for 11 consecutive months.

With the opening of the pre-sale of the 2025 model, the layout of HarmonyOS Zhixing in the new energy vehicle market is more perfect and the product matrix is more abundant. The listing of these two new cars will bring more quality choices to consumers, and their performance in the market in the future is worth looking forward to.

Changjiang Daily Media February 1 (Reporter Wu Ye correspondent Ma Yaoyao) As the Spring Festival approaches, many citizens are busy buying new year’s goods. The doctor reminded that people must pay attention to avoiding the "pit" of allergies when they choose to buy new year’s goods with great joy. The Changjiang Daily reporter learned that the dermatology and ophthalmology clinics in Houhu Campus of central hospital of wuhan recently received many patients with related diseases caused by allergies when buying new year’s goods.

The citizens are buying flowers such as Cymbidium hybridum and Cyclamen. Reporter Li Yonggang photo

Men itch all over after visiting flower shops.

Mr. Liu, 43, lives in Houhu. On the afternoon of January 31, he and his wife went to the flower and bird market to buy some flowers and green plants to decorate the room and increase the atmosphere of the Spring Festival. After coming to the flower and bird market, Mr. Liu didn’t expect that there were not only many kinds of flowers and plants in the Spring Festival atmosphere, but also various meanings. Every time he went to a flower shop, he had to watch them carefully, listen carefully to the boss’s explanation of breeding methods, and sometimes touch the leaves with his hands and put his nose together to smell the flowers.

Not long after returning home, Mr. Liu suddenly felt itchy. After undressing, he was shocked. He found many erythema and wheal on his back, arms and abdomen. Thinking that it was getting late, he didn’t go to the hospital immediately. He endured until the next day and found that his body was more itchy, many skin were scratched, and diarrhea symptoms appeared. The dermatologist in Houhu District of central hospital of wuhan diagnosed that Mr. Liu had urticaria, and further examination revealed that he was allergic. At present, after drug treatment, Mr. Liu’s symptoms have been significantly improved.

Gao Ying, director of dermatology department, said that before the Spring Festival every year, many patients who were exposed to allergens during the purchase of new year’s goods would be admitted to the clinic, causing acute urticaria. Plants themselves are an important class of allergens. The roots, stems, leaves, flowers and fruits of plants can produce allergens. When they enter the human body through ingestion, inhalation or contact, they will induce allergic diseases under certain conditions.

Director Gao reminded that in winter and spring, we should try our best to avoid going to places where there are many flowers, plants and dust mites. Once citizens find that they have symptoms of urticaria, they should go to regular hospitals for examination in time. acute urticaria patients can be cured by taking drugs regularly for one week. However, chronic urticaria can be formed if it is not treated in time or exposed to allergens continuously. Chronic urticaria is difficult to cure, and symptoms can only be controlled through long-term medication.

The eyes of female white-collar workers are itchy after makeup.

Lily, a 25-year-old female white-collar worker, went to many shopping malls to try on cosmetics in order to wear a heavy makeup at the company’s annual meeting, and also bought some good cosmetics for herself for the New Year. Unexpectedly, the next day, her eyes showed symptoms of tears, photophobia and strange itching, and she was diagnosed with allergic conjunctivitis by eye examination in central hospital of wuhan. By further inquiring about her illness, the doctor who attended the clinic learned that Lily usually loves dressing up and never goes out without makeup. Eyeliner, mascara and Cosmetic Contact Lenses are all essential steps. The doctor judged that she tried a variety of cosmetics at the weekend, so that the use of cosmetics around her eyes led to allergic conjunctivitis.

Xiang Yi, director of ophthalmology, said that allergic conjunctivitis is now caused by improper use of cosmetics, wearing contact lenses and pollen, and its incidence is gradually increasing. The main symptoms of allergic conjunctivitis are tears, photophobia and even itching.

Director Xiang reminded that in recent years, cosmetics have also become the new year’s goods selected by young women who like fashion during the Chinese New Year. Cosmetics themselves contain many chemical synthetic substances, which constantly stimulate the tissues around the eyes, which may cause conjunctival allergy and allergic conjunctivitis. Citizens should stay away from inferior cosmetics. People with allergies should stop immediately after using cosmetics and go to the hospital in time.