On March 22, 2019, the DeepTech 2019 Life Science Forum was officially held in Shanghai, China, where scientists, investors and entrepreneurs from the biomedical field gathered to discuss in depth the scientific research innovation, technological revolution and future trends in the life science field. Flagship
Jason Pontin, senior partner of Pioneer, Wang Liqun, president of Fosun Kaite Biotechnology Co., Ltd., Lou Qi, deputy chief economist of Zhangjiang Group and general manager of Zhangjiang Biomedical Base, Wei Wensheng, researcher of Peking University Institute of Life Sciences, and Wang Yanli, researcher of Institute of Biophysics, Chinese Academy of Sciences, shared their exclusive views on emerging technology trends.

　　Figure | DeepTech 2019 Life Science Forum (Source: DeepTech)

　　21
The 21st century is the century of life science. In recent years, the development speed of biotechnology has passed a critical point of innovation, and more and more revolutionary technological breakthroughs have emerged in the field of life science. The world we live in and the life around us are also undergoing revolutionary changes.

　　We believe that the field of life sciences will enter a new era in 2019. In 2019, including CRISPR
Including gene editing, cutting-edge biotechnology such as synthetic biology technology and single-cell omics technology will continue to make revolutionary breakthroughs, and further change the rules of the game in the field of life science, and also change the world we live in.

　　The global market in life sciences and medical health is growing. As early as 2014, China surpassed Japan to become the second largest biomedical market in the world. In 2017, the market size of China’s biomedical industry has reached 341.719 billion yuan. It is predicted that by 2020, the market size of China’s biomedical industry will be twice that of Japan, and it will surpass the United States to become the first in the world.

　　Now, the biomedical market in China is welcoming the "golden age", and more and more emerging technology enterprises are born in China, attracting more and more innovative talents. The booming biomedical industry in China is forming a field that attracts thousands of people’s attention.

　　DeepTech, China’s leading provider of emerging technology content and hard technology services.
In this forum, the "Top Ten Technical Trends in Life Sciences in 2019" was released, and technical trends such as CRISPR Toolkit, immunotherapy 2.0 and curing rare diseases, which have attracted much attention in life sciences, were selected.

　　Figure | Chen Xu, co-founder of DeepTech (source DeepTech)

　　Ten technical trends in life sciences in 2019:

　　1.CRISPR toolkit (CRISPR/Cas Toolkit)

　　More than 30 years ago, scientists found short palindrome repeats in bacteria at regular intervals, and found that such repeats can make bacteria immune to viruses. In 2001, Spanish scientist Francisco
Mojica officially named it CRISPR. In 2012, two female scientists, Jennifer Dudner, a structural biologist from the University of California, Berkeley,
Doudna) and Emmanuelle Elca Pontier of Umemo University in Sweden.
Charpentier) first applied CRISPR/Cas as a gene editing system. In 2013, George from Harvard Medical School
Church, Feng Zhang of the Bode Institute of Massachusetts Institute of Technology, and Xie Lei of the Center for Systems and Synthetic Biology of the University of California, San Francisco (currently working at Stanford University) published three articles respectively, and successfully applied CRISPR/Cas system to mammalian cells.

　　The appearance of CRISPR/Cas9 has led to the explosive development of the whole field of gene editing. Nowadays, many scientists have further expanded CRISPR/Cas gene technology from a single "gene scissors" to a multifunctional "gene toolkit", showing an exciting application prospect based on the ever-expanding CRISPR/Cas system. Scientists predict that CRISPR/Cas9 gene editing technology will change the society in which we live and the creatures around us.

　　2.immunotherapy 2.0(Immunotherapy 2.0)

　　More than 100 years ago, William, an orthopedic surgeon in new york, USA
Coley accidentally discovered that the infection of streptococcus pyogenes after operation made the tumor of sarcoma patients subside, which opened the prelude of tumor immunotherapy, and William was therefore known as the father of tumor immunotherapy.

　　In 2018, the highly anticipated Nobel Prize in Physiology or Medicine was awarded to American scientist James P. Allison and Japanese scientist Tasuku.
Honjo, they have made pioneering contributions to cancer immunotherapy. Nowadays, there are hundreds of companies that carry out cancer immunotherapy in the world, and more than a dozen immunotherapy products in China have applied for clinical trials. The related research results are frequently reported, and they are steadily moving towards the ultimate goal of curing cancer.

　　With the continuous breakthrough of basic and clinical research, our understanding of immunotherapy is also deepening, and the indications of immunotherapy are also expanding. From the initial main position of leukemia, to non-Hodgkin’s lymphoma, multiple myeloma, and then to autoimmune diseases, immunotherapy has entered a more accurate, joint and broad-spectrum 2.0 era.

　　3. Cure of Rare Diseases

　　Under the condition of no error or off-target effect, it is expected to produce predictable beneficial effects by modifying mutant genes through gene editing technology, and even realize a one-time cure of some genetic diseases. Looking back on the development of gene therapy in the past 20 years, it was not until recent years that we really ushered in the era of gene therapy and saw the hope of curing rare diseases at one time.

　　Gene therapy (gene
As a subversive medical technology, therapy has realized that foreign normal genes can be introduced into target cells to correct or compensate diseases caused by defects and abnormal genes, thus achieving the purpose of treating congenital genetic diseases. Today, there are more than 2,500 clinical trials of gene therapy in the world, and gene therapy has become a battleground for global pharmaceutical R&D enterprises.

　　In mid-2018, the US FDA announced that it would continue to vigorously promote the development of gene therapy, and issued six new guidelines, which established a policy framework for how to develop gene products, review and reimbursement by regulatory agencies. At the same time, it also points out the hot fields of human gene therapy, including hemophilia, retinal diseases and rare diseases.

　　In 2019, the treatment of a variety of rare diseases will enter the clinic, and gene therapy will officially enter the stage of rapid development after nearly 20 years. More and more small and medium-sized gene therapy startups have broken ground, and traditional pharmaceutical giants such as Pfizer, Novartis and GlaxoSmithKline have also laid out the field of gene therapy. In China, some start-ups involved in gene editing and some gene therapy projects are expected to enter the clinical stage in 2019.

　　4. Gene Big Data

　　On April 15th, 2003, an international team of scientists from six countries announced the completion of the human genome map. This cost 3 billion dollars, and it is known as the "moon landing plan" of life science.
Our research project has laid a solid foundation for human beings to uncover their own mysteries. The drawing of the human genome map has become an important milestone in the history of human exploration of its own mysteries, and it is also considered by many analysts as a sign of the advent of the biotechnology century.

　　Only after more than ten years, with the development and maturity of technology, the cost of sequencing the whole genome has dropped from 30.
Billion dollars, gradually reduced to hundreds of thousands of dollars, thousands of dollars or even lower, there are also many consumer-oriented genetic testing products on the market. In addition to the well-known applications such as non-invasive prenatal genetic testing and neonatal genetic disease screening, individual genetic testing can also lock in individual pathological genes to achieve early prevention and treatment.

　　Through the genetic detection of individuals, we can realize the prediction of many diseases and even provide more profound insights into individual behavior characteristics. For example, in individual genetic testing products, DNA of individual samples is analyzed.
The analysis of data can interpret the risks of cancer, metabolic diseases, mental illness, etc., and can also interpret the information of individual drug adaptability, sports talent, alcohol consumption and so on. As millions or even tens of millions of individuals around the world have completed the interpretation and analysis of personal genome data, there have been some based on.
Emerging technologies with more striking DNA information, such as DNA criminal investigation and new drug prediction, have made revolutionary progress in these fields. We have also ushered in a revolutionary era brought by DNA data.

　　5. Nucleic Acid Drugs

　　In the field of new drug research and development, targeted therapy for target protein has become the mainstream, and gene therapy for DNA mutation is also in full swing. As a bridge between gene and protein, mRNA.
More and more attention has been paid in recent years. In addition, scientists also found that there is a unique gene silencing mechanism in eukaryotic cells, which can resist the invasion of foreign substances, protect the stability of genetic information, and regulate various functions of organisms, also known as
RNA interference (RNAi) phenomenon.

　　The RNAi mechanism was first discovered by Professor Andrew Z.Fire and Professor Craig C.Mello in 1998, and was recognized by Science in 2002.
The magazine ranked first among the top ten scientific achievements and won the Nobel Prize in Physiology or Medicine in 2006. The discovery of RNAi has greatly broadened the source and development direction of human drugs. Today, with
Oligonucleotide drugs based on siRNA (small interfering RNA) and miRNA (microRNA), and mRNA therapeutic drugs, mRNA vaccines and CRISPR RNA.
Mainly ribonucleic acid drugs, together constitute the nucleic acid drugs.

　　A large number of studies show that nucleic acids and their degradation products and derivatives have good therapeutic effects, and we are also welcoming a new era of mRNA drugs and RNAi drugs. In theory, nucleic acid drugs can achieve irreplaceable effects of traditional drugs. Like small molecular drugs, they can play a role in cells, even affect the nucleus and have precise targeting. They are also very advantageous for some single-gene disease nucleic acid drugs. In the era of global precision medicine, diseases caused by different gene differences or abnormal expression can theoretically be individually developed by nucleic acid drugs.

　　6. Brain science and brain-computer interface.

　　Brain science is the "ultimate territory" for human beings to understand natural phenomena and human beings themselves, and brain science research is also called "the ultimate challenge for human beings to understand nature and themselves". In recent years, countries all over the world have launched their own "brain plans", and their goals can be summarized as follows: (1) analysis of the neural basis of various brain functions; Using the new information obtained from neural circuit research, develop new methods for effective diagnosis and treatment of brain diseases; Carry out brain-like research inspired by brain science and promote the progress of a new generation of artificial intelligence technology.

　　With the emergence of new technologies such as brain imaging, biosensing, human-computer interaction and big data, brain science and brain-like research are increasingly becoming one of the key scientific fields that countries around the world are scrambling to study. Under the impetus of "Brain Project", some exciting applications are expected to appear in the field of "brain science", including brain like computing system, brain-computer interface and a new model of brain-computer fusion, and it is expected to promote the development of brain disease diagnosis and treatment, artificial intelligence and other fields.

　　7. Smart Medical Care

　　In the future, the medical industry will integrate more artificial intelligence, sensing technology and other high technologies, so that medical services will move towards real intelligence and promote the prosperity and development of medical undertakings. Artificial intelligence has played an important role in the medical field, such as medical image recognition, biotechnology, auxiliary diagnosis, drug research and development, nutrition and other fields, and will change medical methods and even medical models.

　　By 2025, the total value of the world artificial intelligence market will reach 1270.
Among them, the medical industry will account for 1/5 of the market size, and medical AI will become one of the most important application scenarios of artificial intelligence. On the other hand, data, as an important support of artificial intelligence, has become the key content of smart medical construction and development. The emergence of a new generation of communication technology and the development of Internet of Things chip technology have also promoted the great commercialization of mobile medical equipment, especially all kinds of intelligent devices, sensors and other medical and health equipment, which mainly monitor health such as exercise, heart rhythm and sleep.

　　8. Non-Invasive Early Diagnosis.

　　In recent years, in the direction of tumor diagnosis, with the continuous development of genome sequencing technology, tumors are circulated in peripheral blood.
Liquid biopsy with DNA(ctDNA) as the main marker has become the most potential technique for early accurate diagnosis of tumors.

　　Liquid biopsy based on gene imaging and sequencing methods can identify and monitor tumors in the early stage, artificial intelligence and the application of gene big data. Combined with liquid biopsy, it provides an effective early screening method for most cancers and provides clues for early diagnosis of cancer, accurate determination of cancer types, prediction of cancer spread and prognosis management.

　　9. Synthetic Biology Technology.

　　In essence, a computer is a machine that can process information through certain algorithms. The more powerful the computer circuit, the more complex calculations and algorithms can be carried out. Similarly, cells can be transformed by genetic engineering like a mini-computer. The more complex the circuit, the stronger the computing power.

　　As the third biotechnology revolution, synthetic biology, which was born in the early 21st century, has brought subversive changes to human social life. Artificially designed cells will be able to deliver drugs to patients regularly in vivo; The sex of silkworm, mosquito and other insects can be controlled by genetic design; Gene editing can double the speed of breeding … These are magical changes brought by synthetic biology.

　　In recent years, with the continuous innovation of genome editing technology such as CRISPR, as well as the equally rapid development of big data, artificial intelligence and robotics, the prospect of synthetic biology has become more and more clear, and the industrialization of synthetic biology has ushered in an explosive period.

　　10. Single-cell Multiomics.

　　Cells are the basic units that constitute the structure and function of life. Different types of cells have different shapes and functions. Even if the cells of the same kind seem to be the same, there are extensive cell heterogeneity among them. The early average data obtained based on population cell analysis often ignored the differences among cells.

　　With the development of cell separation and next-generation sequencing, researchers can study DNA, RNA, protein and chromatin of a single cell. Scientists have begun to combine multi-layer information with single-cell resolution to reveal single-cell genome, transcriptome, methylation, protein omics and other data.

　　In 2009, the first single-cell transcriptome sequencing technology appeared; Single cell genome sequencing technology appeared in 2011; In 2013, single cell genome-wide DNA methylation detection technology appeared. Subsequently, scientists continued to optimize and improve cell sorting technology, nucleic acid amplification technology, signal-to-noise ratio improvement, etc., and further created sequencing and analysis technologies at different levels of single-cell omics.

　　Single-cell omics technology allows us to identify specific cells and their functions more clearly, and can provide unprecedented clinical and scientific research data, helping scientists to understand the physiological and pathological mechanisms of organisms more accurately and deeply, such as the differentiation of stem cells, the development of nerve cells, the pathological mechanism of cancer cells, the function of immune cells, etc., and provides guidance for the formulation of individualized precision medical programs.

　　Jason Pontin, senior partner of Flagship Pioneering, explained the top ten technology trends one by one.

　　Mr. Jason Pontin is currently a famous biomedical venture capital firm in Boston, Flagship Pioneer.
Senior partner, mainly responsible for the company’s strategic communication and the construction of enterprise entrepreneurship ecosystem. He is also a famous American opinion leader in science and technology. Mr. Jason Pontin from 2005 to 2017
Years in the MIT Technology Review (MIT Technology
Review) as CEO, publisher and editor-in-chief, responsible for the editing direction, media platform and business strategy of MIT Science and Technology Review. In addition, he has written for many famous American and global media, including The Economist, Financial Times and Wired in The New York Times.

　　Figure | Jason Pontin, Senior Partner of Flagship Pioneering (Source: DeepTech)

　　Jason Pontin introduced 11 kinds of technology trends that he is concerned about, the first of which is CRISPR. Jason
Pontin thinks that CRISPR is like a gift from heaven, full of sci-fi significance, but at present, we can’t master this technology, and it may be another 40 years before we can know the secret and core of CRISPR. Jason also expressed his views on the previously concerned baby event of gene editing. He thinks that people pay too much attention to the baby of gene editing of CRISPR. At present, it is uncertain about the consequences that knocking out CCR5 gene will bring to human body, but he believes that with the passage of time, there will be a relatively reasonable framework and policies.

　　Jason
Pontin also put forward a new direction of gene editing, that is, combining stem cells with gene editing, for example, inducing easily obtained somatic cells back to differentiated stem cells, which is safer and more controllable and has great potential in clinic.

　　Meanwhile, at DeepTech,
At the 2019 Life Science Forum, Zhao Ruilin, a partner of Chende Capital, shared possible hot spots in biomedical investment in the next three to five years. Zhao Ruilin believes that the application of AI+ big data, early cancer screening, gene therapy, consumer-oriented gene sequencing and surgical robots will become hot spots for investment in the next three to five years.

　　At the same time, Zhao Ruilin also pointed out that several medical big data companies can not succeed in a day or two. The capital market is also a test of who can get to the end. Everyone sees the prospect of big data applications, but how can we get to the end? How can we get to the day when gold is dug up? This is something that everyone should consider. For early screening of cancer, Zhao Ruilin believes that the fundamental principle of imaging technologies such as MRI and CT is that I want to see cancer. And what is cancer early screening instead of imaging technology? In the future, when molecular diagnosis is really powerful, when there are no image markers, we can already detect cancer. Of course, this is a vision, and we have to achieve this goal.

　　Figure | Zhao Ruilin, Partner of Chende Capital (Source: DeepTech)

　　Wang Liqun, president of Fosun Kaite Biotechnology Co., Ltd., delivered a speech at the meeting. He said that China still faces many challenges in the industrialization of CAR-T therapy. We don’t have to worry about being too far behind foreign countries, but don’t blindly think that we are the first.

　　Dr. Wang Liqun said that we still have a lot to improve in terms of technology, quality, time, production capacity and cost. For example, whether the technology can be better, whether the cost can be lower, how to overcome these tumors and microenvironment, including the inhibition of solid tumors to make another product, and commercial applications, there are many things to be explored and tried, but in the end we have to return to our original intention, and how to really use a good product to treat our patients.

　　At the same time, he also mentioned that many media said that China is the world’s number one in CAR-T, and in clinical research, our clinical data is more than that of the United States, which is a wrong concept. Clinical trials in the United States are supervised clinical trials, while most of the data reported in China are not supervised, which is quite different. We can’t be so hot-headed that we think that CAR-T is the first because we have done more clinical projects. Dr. Wang Liqun said that he hoped that China could attach importance to the supervision of CAR-T as a drug, which was beneficial to the development of the whole industry. CAR-T is revolutionary as a means of tumor treatment. Everyone is at the same starting line. We don’t have to worry about being too far behind foreign countries, but don’t blindly think that we are the first.

　　Figure | Wang Liqun, President of Fosun Kate Biotechnology Co., Ltd. (Source: DeepTech)

　　In the afternoon round-table discussion, Yang Fang, a partner of PricewaterhouseCoopers Capital Markets, answered the question of how to treat medical data sharing. She believed that the future was bright and the process was painful. China is a big country of medical data, but the systems used in each hospital are not necessarily the same, and the data structures are also different. It takes a lot of time and energy to make these unified structured data. But the final prospect is definitely bright, but it will take a lot of time and energy before reaching that line.

　　Figure | Yang Fang, Partner of PricewaterhouseCoopers Capital Markets (Source: DeepTech)

　　The forum also announced ten "DeepTech 2019 Innovative People in Life Sciences".

　　Chen Xu, co-founder of DeepTech, said that this DeepTech
The selection of 2019 innovators focuses on the key contributions and achievements made by these ten scientists and entrepreneurs in the future subversive and transformative technology hotspot trends in the life sciences.

　　Chen Xu said that this list should highlight not only the achievements of scientists and entrepreneurs, DeeTech.
It is also hoped that through the presentation of innovative figures, the possible path of future development in the field of life sciences can be described more vividly and located more accurately.

　　Cong Le, a young scientist who brought CRISPR gene editing technology to the human gene world, cut CRISPR/Cas for the first time.
The system was upgraded to the gene editor "Swiss Army Knife" CRISPR-dCas.
Lei Lei, an associate professor of bioengineering at Stanford University, and Shao Yangyang, a postdoctoral fellow at the Institute of Plant Physiology and Ecology, Shanghai Institute of Life Sciences, Chinese Academy of Sciences, who created the world’s first single chromosome eukaryotic cell, won this award. The ten winners were respectively
Ten technical trends in life sciences in 2019 shared their views, and Shao Yangyang, Wang Yanli and others also shared the innovation achievements in their respective fields at the forum.

　　From gene magic scissors, gene erasers edited by single base to today’s "Swiss Army Knife", the field of gene editing has been transformed and turned upside down in recent years. For one of the top ten technical trends in the field of life sciences in 2019,
CRISPR Toolkit, according to Qi Lei, "In CRISPR based on bacterial sources.
In the gene editing system, we acquire and enrich this toolkit by enhancing the function and activity of the corresponding proteins, and realize safer and more effective gene regulation. The appearance of these tools not only provides a brand-new scheme for future genetic engineering and treatment, but also provides a powerful tool for the comprehensive study of genes and their importance in life. We are very much looking forward to it.
CRISPR toolkit can continuously create miracles in both research tools and therapeutic applications for the benefit of mankind. "

　　The creation of the world’s first eukaryotic cell containing only a single chromosome marks a milestone in China’s synthetic biology! As the implementer of this great achievement, Dr. Shao Yangyang mentioned in his keynote speech that the three-dimensional structure of yeast cells’ sixteen chromosomes has changed dramatically after they were merged into one, but the transcription group and phenotype group of cells have not changed much, which subverts the traditional idea that the three-dimensional structure of chromosomes affects gene expression. This is also the first time to explore the relationship between the evolution of higher organisms and the structure and function of chromosomes through synthetic biology. Moreover, a series of yeasts with decreasing chromosome numbers constructed in the process of gradually merging sixteen chromosomes into one are undoubtedly valuable materials for studying telomere-related aging and cancer.

　　Figure | Dr. Shao Yangyang (Source: DeepTech)

　　Kong Lingjie, an associate professor of precision instruments in Tsinghua University, analyzed brain science in his keynote speech. He said that brain science still faces many challenges at present. In the field of cerebral cortex, it is urgent to upgrade the existing imaging technology and pursue a wider, deeper and faster imaging technology. Kong Lingjie team developed deep tissue imaging technology and three-dimensional high-speed microscopic imaging technology, and recently cooperated with Academician Dai Qionghai of Tsinghua University to realize large-scale, high-resolution and real-time dynamic imaging. By applying the new technical means to science, we can observe the neural activity in a specific behavior pattern, infer the functional connection and structural connection of neurons, statistically analyze the information processing mechanism of brain neural network, and apply the above information to the development of new artificial intelligence technology to promote the development of artificial intelligence.

　　Figure | Associate Professor Kong Lingjie (Source: DeepTech)

　　Innovative figures in the field of life sciences in 2019

　　(Sorted by spelling initials of last name)

　　1. Cong Le, a researcher at the Broad Institute of MIT-Harvard University.

　　As one of the innovative scientists who brought CRISPR gene editing technology to the human gene world, Cong Le used CRISPR/Cas9 system to act on human and mouse cell genes for the first time, and revealed the application potential of related technologies in gene therapy, especially in the treatment of cardiovascular and cerebrovascular diseases and cancer. At present, Cong Le focuses on the research of single cell sequencing, genomics and systems biology, and combines with gene editing technology to explore the immunological mechanism of cancer and the development of therapies for cancer immune regulation.

　　2. Han Bicheng, founder and CEO of BrainCo and BrainRobotics.

　　As one of the innovative entrepreneurs who put brain-computer interface technology into commercial application, Han Bicheng founded BrainCo, a brain-computer interface technology company, while studying for a doctorate in brain science at Harvard University Brain Science Center.
. He founded a semi-public welfare project to manufacture intelligent prostheses for the disabled.
BrainRobotics, the product developed can help disabled people to control prostheses and fingers through their minds and realize flexible movement. At the same time, BrainCo’s team is developing the world’s first brain information processing chip combined with artificial intelligence algorithm.

　　3. He Ting, founder and CEO of Yimiao Shenzhou Medical Technology

　　As one of the innovative entrepreneurs who are committed to applying CAR-T technology and gene cell drugs to the treatment of malignant tumors, He Ting founded Beijing Yimiao Shenzhou Medical Technology Co., Ltd.. IM19, the company’s candidate CAR-T new drug product, has shown exciting efficacy in early clinical research, which is expected to greatly improve the treatment status of advanced hematological tumors.

　　4. Kong Lingjie, Associate Professor, Department of Precision Instruments, Tsinghua University.

　　As one of the innovative scientists focusing on method innovation, system design and integration in the field of neuroimaging, Kong Lingjie designed and developed a three-dimensional high-speed two-photon fluorescence microscopic imaging system, developed a deep tissue microscopic system based on adaptive optics, and participated in the research and development of the world’s first 1-billion-pixel imaging system with video frame rate, centimeter-level field of view and sub-micron resolution. Kong Lingjie’s research from "understanding brain" to "simulating brain" is not only an important technical support for China’s "brain project" in the future, but also a key link between brain science and the transformation of artificial intelligence.

　　5. Li Teng, founder and CEO of Beijing Lanjing Microbiology Technology Co., Ltd.

　　As one of the innovative entrepreneurs who applied synthetic biology technology to optimize life systems and develop new microbial products to solve ecological problems, Li Teng discovered a salt-tolerant and alkali-tolerant bacterium in Aiding Lake, Xinjiang, which greatly reduced the production cost of biodegradable polyhydroxy fatty acid esters (PHA). In addition, its leading team has developed a brand-new data management system.
Holog has improved the data and automation level of R&D process, established a soft and hard integrated laboratory, and greatly improved the engineering level of microbial synthesis.

　　6. Qi Lei, Associate Professor of Bioengineering, Stanford University

　　As one of the co-inventors of CRISPR gene editing technology in China and EU patents, Qi Lei upgraded the gene magic scissors CRISPR/Cas system to the "Swiss Army Knife" for the first time.
CRISPR-dCas, and based on this, it expanded its application, and successively invented the system based on CRISPR.
The gene switch (CRISPRi/a) enables the specific gene expression to be accurately turned on or off without introducing mutation. A series of CRISPR technologies invented by Qi Lei greatly expanded "genetic engineering" and then changed the definition of "genetic engineering".

　　7. Shao Yangyang, postdoctoral fellow, Institute of Plant Physiology and Ecology, Shanghai Institute of Life Sciences, Chinese Academy of Sciences.

　　As one of the innovative scientists who explored and analyzed the origin and evolution of eukaryotic cells through the "engineering" method of synthetic biology for the first time, Shao Yangyang participated in the creation of the world’s first single chromosome eukaryotic cell and achieved a milestone breakthrough in "artificial life". Shao Yangyang’s research provides a new idea for exploring the relationship between chromosome structure and function in higher organisms and a useful model for studying telomere-related aging and cancer.

　　8. Wang Yanli, researcher of Institute of Biophysics, Chinese Academy of Sciences, professor of Chinese Academy of Sciences.

　　As one of the innovative scientists who have made great breakthroughs in the field of CRISPR/Cas mechanism research, Wang Yanli’s research work mainly focuses on the mechanism of CRISPR/Cas system and RNA interference (RNA
Study on the structure and function of interference (RNA) related proteins. From 2014 to 2018, Wang Yanli team made great breakthroughs in the above research fields and made original and outstanding contributions to the mechanism clarification of CRISPR/Cas system.

　　9. Xie Dan, researcher at the State Key Laboratory of Biotherapy, Sichuan University.

　　As one of the innovative scientists who are committed to developing Qualcomm’s high-resolution single-cell multimethology composite sequencing technology and using single-cell sequencing technology to study tumor occurrence, development and transformation of non-invasive liquid biopsy diagnosis technology, Xie Dan has systematically studied various gene regulation mechanisms and differences in epigenetic spectra between genomes in the fields of multimethology data and bioinformatics, combining with the rapidly developing sequencing technology and machine learning methods, and revealed the molecular mechanism of gene regulation leading to trait differences and the corresponding relationship between human multimethology and diseases.

　　10. Zou Hao, founder and CEO of Qingying Medical

　　As one of the innovative entrepreneurs who introduced the "advanced version" of artificial intelligence technology into the medical field and trained a high-sensitivity and high-stability medical data analysis system with small-scale data sets, Zou Hao, who was born in Tsinghua "Yao Ban", devoted himself to exploring the deep application of artificial intelligence in medical imaging and big data health. Qingying Medical, founded by Qingying Medical, has cooperated closely with many top clinical hospitals in China during its growth for just over a year, and has become an innovative example of cross-border integration of medical industry and artificial intelligence technology in start-ups.

　　

　　struggle

　　The best of us

　　Dear, beloved

　　From Exclusive Memory and Youth Fight at the beginning of the year, to Our Warm Hours, I only like you some time ago, and then to Struggle, Teenager, which just ended and caused fans to call for the second season, and I’ll wait for you in the future. Youth drama continues to exert its strength on this year’s small screen, all the way from the graduation season to the opening season.

　　Struggle, produced by Zhao Baogang 12 years ago, defined the 1.0 period of youth drama, and then the 2.0 period, which was based on literary IP, came quietly. For more than ten years, the theme of youth has been going through ups and downs, and now it has gone through three generations of changes, gradually opening the "Youth+"3.0 period with various elements. Although the new batch of works have different degrees of extension and innovation in subject matter, and the creative level is basically up to standard, they have never been able to create a phenomenal work that has aroused public discussion.

　　The realistic period of 1.0

　　Depicting youth group images from campus to society.

　　Masterpieces: Struggle, Who is in charge of my youth and Beijing Youth.

　　The theme of youth has become the darling of the screen, which is closely related to Zhao Baogang’s "Youth Trilogy" to some extent. In 2007, "Struggle" was born, which made the stories of Charlene Marilynn Dangelo, Lu Tao, Milai and Xiangnan become people’s talk after dinner. Since then, Zhao Baogang has made the youth drama "out of the circle" successfully with his works such as Who is in charge of my youth and Beijing Youth, and has become a popular movie theme for all ages.

　　It is Zhao Baogang’s consistent creative attitude to express his observation of society and life through his works. This batch of youth dramas also adheres to this tradition, focusing on realism in subject matter, focusing on the life node of college students going to society, and showing the pain caused by identity transformation in a large space.

　　Grasping the current hot topics in society and creating new hot topics are the soul of the theme of youth in this period.

　　With the influx of well-packaged overseas dramas and the impact of a large amount of capital entering the film and television industry, IP adaptation and original remake gradually replaced the popularity of realistic themes, which also made the youth drama in this period end in the colorful chapter of Beijing Love Story.

　　The nostalgic period of 2.0

　　Recall the individual beauty of childhood.

　　Masterpieces: "Zhenhua Trilogy", "In a hurry that year" and "To our simple little beauty"

　　After years of silence, the resurgence of youth dramas depends on the injection of powerful IP and the change of viewing habits from screen to mobile port. In 2016, The Best of Us, which was quietly launched in iQiyi, broke the vacancy and indifference of youth theme for a long time. This online drama, which only tells about ordinary high school campus life, has touched a large audience outside the student group.

　　It is quite different from the youth dramas in Zhao Baogang era. At this time, most of the leading works are adaptations of powerful IP blessing. Among them, including "The Best of Us" and "Hello, Old Times", the series of plays called "Zhenhua Trilogy" has achieved outstanding results.

　　With the convenience brought by adaptation, this nostalgia for youth has intensified and similar works have emerged one after another. These works pay too much attention to the creation of feelings and the expression of youth pain, with a small story pattern and limited narrative span. Especially in the use of actors, they gradually began to pursue flow, awareness and youthfulness, which made the short-lived youth drama quickly become the hardest hit area for embarrassing acting and bloody plot.

　　Youth+period of 3.0

　　Hot-blooded elements with youthful characteristics

　　Masterpieces: Dear, Loving, Struggle, Teenager, I’ll wait for you in the future.

　　"A generation will eventually grow old, and some people are always young". A group of youthful dramas dancing with blood and gas followed. Counting the explosive dramas of satellite TV and online platforms this year, the composite theme of "Youth+"mode is welcoming its debut.

　　In the summer file, Dear, which is "Youth+E-sports", Li Xian, who has been tepid for many years, has become the top traffic. At the end of August, Struggle, Teenager, which just finished in Hunan Satellite TV, is also a composite type of "Youth+Competition".

　　On the other hand, Classmate 200 Million Years Old, which was launched in the middle of last year, The Night of Comet, and I’m waiting for you in the future, which are being broadcast at the beginning of this year, have opened a new mode of "youth+fantasy" in another way. Although it incorporates fantasy elements, the story narrative is not a continuation of "crossing" and "fantasy", and the content is still the real life after processing.

　　"Youth" is not limited to the ignorance of minor emotions and the noise of small fights. No matter how rich the elements are, only by returning to life and reality can we define the true classic youth. (Reporter Mei Dongni)

Meeting site

Meeting site

　　Cctv news The state of safe production of construction machinery is closely related to the situation of safe production in construction, a high-risk industry. According to incomplete statistics, there are more than 20 million sets of construction machinery and equipment in China, with more than 30 million employees. Among them, 80% of the construction machinery and equipment are in the hands of individuals, and a large number of operators have never entered training courses and are seriously undocumented.

　　In recent years, although all parties concerned have done a lot of work, due to various reasons, there are still a large number of hidden dangers in the operation of construction machinery, and casualties have occurred frequently, including serious accidents. In order to improve the safety production level of construction machinery and make it play a better role in the national economic construction, especially in the construction of projects such as "Belt and Road" and "integration of defense and civilian technologies", on August 9, 2017, the (first) China construction machinery safety production and dialogue Beidou assisted construction machinery "Belt and Road" and integration of defense and civilian technologies construction summit forum was held in Beijing.

　　The forum was jointly organized by the Innovation Investment and Financing Committee of China Investment Association, World Wide Web, Economic Reference of the State Council Development Research Center, China Satellite Navigation and Positioning Association and Zhongan Construction Machinery Management Co., Ltd. The theme of the forum is "Safe and Green Sharing". More than 120 people from the government, domestic and foreign construction machinery enterprises, experts and scholars attended the meeting. The Opinions of the State Council, the Central Committee of the Communist Party of China on Promoting the Reform and Development in the Field of Safety Production emphasizes that "the production and manufacturing standards of long-distance passenger vehicles, tourist buses, dangerous goods transport vehicles and ships should be improved, the safety performance should be improved, intelligent video monitoring and alarm, anti-collision and supervision technology and equipment for the safe operation of the whole vehicle should be compulsory, and the transformation and upgrading of safety technology and equipment that has been operated should be accelerated", "the formulation, revision and integration of safety production standards should be accelerated, and a safety production standard system with mandatory national standards as the main body should be established. Encourage social organizations and enterprises established according to law to formulate stricter and more standardized safety production standards, and actively learn from and implement international advanced standards in light of national conditions. " Based on the relevant contents of these Opinions, the forum gave speeches, demonstrations, dialogues and discussions on the mandatory installation of safety technical equipment for construction machinery, the formulation and improvement of relevant safety production standards, the training of construction machinery operators, and the establishment of "intelligent safety management service platform for construction machinery". It also discusses the application of construction machinery in ensuring ‘Belt and Road ’ And the construction of integration of defense and civilian technologies.

　　The forum also held a flag-raising ceremony, which started a meaningful action, that is, Zhongan Construction Machinery Management Co., Ltd. shouldered a social responsibility and creatively launched the "China-An Safety Production Miles" activity, which will focus on construction machinery and carry out a series of publicity and education activities such as safety production laws and regulations, so as to promote the awareness of construction machinery safety production and accident prevention measures. It is reported that the activity of "China-Angola Safety Production Miles" will be carried out normally in a major construction machinery province, with Shaanxi as the first stop. Zhongan Construction Machinery Management Co., Ltd. was the lead unit of propose to create China Construction Machinery Safety Alliance last November, and now it is the chairman unit of the Preparatory Committee of China Construction Machinery Safety Alliance.

　　(First Session) China Construction Machinery Safety Production and Dialogue "One Belt and One Road" and integration of defense and civilian technologies Construction Summit Forum have opened a brand-new communication and exchange channel for the "safety production" of construction machinery industry, which is of great significance for promoting and improving the safety production level of construction machinery, further promoting the safety production level of high-risk industries in construction, and further improving the safety production support ability of construction machinery industry for various construction projects.

　

　　From April 13th to 15th, Chen Yichao’s bribery case was heard in the People’s Court of Ganzhou District, Zhangye City, Gansu Province. China Youth Daily Zhongqing Online Reporter Lu Yijie/photo

　　On November 25, 2011, Fan Xiuling (left) and Chen Yichao (right) gave the personal account named "Jia Yuan" a voucher for transfer. Fan Xiuling/Photo courtesy

　　Chen Yichao, 57, has gray hair. He hunched slightly and limped into the court, expressionless.

　　At one time, the gold merchant’s biggest handwriting was to earn 100 million yuan in one fell swoop; However, after the procuratorate found that he paid a bribe of 300,000 yuan for a car, he lost his freedom. Although there is no trial or conviction, as early as more than four years ago, Chen Yichao’s property of at least 10 million yuan has nothing to do with him — — Some commission for discipline inspection, discipline inspection cadres and prosecutors have become the masters of these wealth.

　　Among these properties, three cars were transferred to the General Office of the CPC Gansu Provincial Commission for Discipline Inspection, and two cars were changed to the name of the staff of the People’s Procuratorate of Ganzhou District, Zhangye City, Gansu Province. In addition, at least 9.52 million yuan of funds were transferred to the personal accounts of the discipline inspection cadres in Gansu Province and the prosecutors handling cases in the People’s Procuratorate of Ganzhou District, and one of the transfers was handled by the wife of the discipline inspection cadres working in the bank.

　　The interviewed scholars told China Youth Daily and Zhongqing Online reporter that in the process of criminal proceedings, any institution can only temporarily detain the property before the court decides, and cannot transfer the ownership. If the property is transferred to an individual’s name, "it is a violation of discipline and a new corruption."

　　"In this case, I think it is not a big deal to be suspected of bribery. The big thing is these properties!" At the trial site of Ganzhou District People’s Court on April 13, Chen Yichao, who pleaded not guilty, said that he would report the case handlers.

　　Gold miners were questioned by prosecutors at the provincial commission for discipline inspection.

　　Chen Yichao is from Tianshui, Gansu. Earlier, he worked in Tianshui Station of Gansu Provincial Material Administration Bureau for 17 years. There was a special railway line for transporting ore in the station, and he contacted a group of people who "mined". In the mid-1990s, when the Property Management Bureau was restructured, Chen Yichao decided to find his own way out and do "mining" business.

　　The gold mine brought wealth to Chen Yichao, which also made his fate turn sharply. In late May 2011, he was taken away by the case handlers in Lanzhou, and then the case handlers found his wife Fan Xiuling from the hotel.

　　Fan Xiuling used to be an employee of a bank in Tianshui. She recalled that she was asked about the relationship between Chen Yichao and citic guoan Gold Company, and what property she had at home, such as real estate, vehicles and deposits in bank cards.

　　Citic guoan Gold Company is a wholly state-owned subsidiary of CITIC Guoan Group, which is well-known in the domestic gold industry. In May 2000, Chen Yichao, who wanted to develop Toutanzi Gold Mine in Huixian County, Gansu Province, reached a cooperation intention with the gold company in the name of a company.

　　In the next three years, the Gold Company won the exploration right and decided to set up a new joint-stock company in cooperation with another state-owned enterprise in Huixian County. The Gold Company invested in mining rights and held 37% of the shares.

　　Due to the restructuring and other reasons, the gold company actually withdrew from business. In June 2006, Chen Yichao agreed to transfer 37% of his shares in the name of Gold Company, which made him earn 101.88 million yuan.

　　"Many of the previous investments were made by others, and this income has to be paid back." Fan Xiuling said. After several years of hard work, Chen Yichao bought eight properties in Beijing, Shanghai, Xiamen and Sanya, including BMW, Mitsubishi and Audi.

　　These properties are now considered by Ganzhou District People’s Procuratorate to be purchased with illegally profited funds. The indictment alleges that in the process of cooperation with the gold company, Chen Yichao repeatedly promised to reward Liu Wenge, the former deputy general manager of the company, after making profits. In May 2007, Liu Wenge offered to buy a car for him, and Chen Yichao paid 307,000 yuan with his personal bank card and bought a Toyota Camry car for Liu Wenge.

　　According to the indictment, Chen Yichao concealed the fact of cooperation with the gold company and obtained the exploration right in the name of the company; Without application, approval, filing or approval, the exploration right was privately invested in the name of the gold company, and then transferred to other companies, which obtained huge illegal benefits and "actually made a profit of 95.17 million yuan".

　　On May 29, 2011, the People’s Procuratorate of Ganzhou District decided to place him under residential surveillance. At first, he was suspected of corruption.

　　Chen Yichao, who is not from party member, has experienced the plot that he only saw on TV. According to the investigation or interrogation record of Gansu Provincial Commission for Discipline Inspection and Ganzhou District People’s Procuratorate, he was investigated or interrogated many times in the "case handling point of Jin Peng Building Provincial Commission for Discipline Inspection in Lanzhou City". The interrogators and investigators were both Ganzhou District prosecutors and Gansu Provincial Commission for Discipline Inspection cadres.

　　At the scene of the trial, Chen Yichao repeatedly said that he had been living in the case-handling point of the Provincial Commission for Discipline Inspection of Jin Peng Building during more than 200 days of residential surveillance. The prosecutor did not deny this.

　　According to the reporter’s field visit on April 10th this year, the Jin Peng Building, which opened in 2004, has 12 floors, and only all the street windows on the fifth floor are surrounded by iron bars. Fan Xiuling said that the fifth floor is the case handling point. The reporter tried to stay on the fifth floor of the building, but the waiter declined on the grounds that the water pipe was broken and there was no hot water.

　　Search, seizure and freezing, Chen Yichao’s property was involved in the storm of criminal cases. On the third day of residential surveillance, the Gansu Provincial Commission for Discipline Inspection temporarily withheld the "cash of 300,000 yuan" involved. A month later, all vehicles under Chen Yichao’s name were temporarily detained.

　　At least 9.52 million yuan has been transferred to the personal account of discipline inspection cadres or prosecutors.

　　There are more and more properties withheld and sealed, and Fan Xiuling didn’t know where the money was stored until November 25, 2011.

　　Fan Xiuling said that the investigators found her and asked her to remit 700,000 yuan from her China bank account with the last number of 1584 to a personal name called Jia Yuan. Jia Yuan is a cadre of Gansu Provincial Commission for Discipline Inspection contacted by Fan Xiuling. According to public reports, in 2013, Jia Yuan was still attending the meeting of the discipline inspection department in Gansu Province.

　　"I’m not voluntary, I said I don’t turn. The case handler said that this was illegal income. I think the statement is weird, but I don’t understand it specifically. In the end, it’s not up to me. " Fan Xiuling said, "I don’t know about other issues, but I work in a bank and I have to use a court judgment to deduct deposits. I know that."

　　The Application for Remittance in China Bank shows that the purpose of this remittance is "case payment". Another Receipt for Bank Card Withdrawal of Agricultural Bank of China stated that on the same day, Jia Yuan also received a "Kaka Transfer" of 900,000 yuan from Chen Yichao’s bank card.

　　On the same day, the Gansu Provincial Commission for Discipline Inspection recorded in the registration form of temporarily detained and sealed items that "the cash involved in the case handed over by Fan Xiuling was 1.6 million yuan only", which was the sum of the two transfers. The registration form shows that the custodian of this paragraph is Jia Yuan. The reporter found that the custodian of the other six registration forms is also Jia Yuan.

　　On this day, Chen Yichao was released from residential surveillance and changed to bail pending trial, and the alleged crime was also changed to bribery.

　　Chen Yichao and his wife began to investigate where the money was temporarily detained and sealed. They retrieved the bank voucher and found that at least 5 funds and 8.52 million yuan had been transferred to Jia Yuan’s personal account with the ending number of 8717. The opening bank of this account is Lanzhou Jinchang Road Sub-branch of Agricultural Bank of China, and the seal of one receipt shows that the manager is a Ms. Zhu.

　　China Youth Daily reporter came to the business office of the branch on April 11th this year. Many employees said that Ms. Zhu was indeed an employee in the business office and worked on the 5th floor of the building. Official sources confirmed that she was the wife of a cadre of Gansu Provincial Commission for Discipline Inspection. The cadre participated in the investigation of Chen Yichao’s case, and his name was seen in the transcript many times.

　　Among the aforementioned transfers, the earliest known transfer was RMB 1.803 million on October 19, 2011, which was used as "payable". At that time, Chen Yichao was still monitoring his residence.

　　The name "Sun Wannian" was signed at the signature of the remitter and the blank space of the payee’s information. The reporter found that the contact number left in the "payer" column was also Sun Wannian’s. He was qualified as a senior auditor in 2010. In a public information in March 2012, he was identified as the deputy director of the Audit Bureau of Tianzhu County, Gansu Province.

　　The personal account of the prosecutor also received the money involved. On November 7, 2011, a man surnamed Yan’s account had 1 million yuan remitted to the account of Industrial and Commercial Bank of China named "Chen Guoxun". Four days later, the money was recorded in the registration form of temporarily detained and sealed articles of Gansu Provincial Commission for Discipline Inspection, and the witness was Chen Guoxun.

　　Chen Guoxun is the prosecutor of the Anti-Corruption Bureau of Ganzhou District Procuratorate who interrogated Chen Yichao. In April 2014, Chen was appointed as a member of the Procuratorial Committee of Ganzhou District Procuratorate.

　　Li Chengyan, a professor at the School of Government Administration of Peking University, told reporters that no matter what the situation, there are serious problems in transferring the money involved into personal accounts, which are unreasonable, unreasonable and illegal. Zhu Xiaoding, a defense lawyer and lawyer of Beijing Cailiang Law Firm, presented these transfer vouchers during the trial.

　　The prosecutor responded that if there is evidence that the money is remitted to the personal name of the prosecutor and the cadre of the Commission for Discipline Inspection, it can be reported and charged.

　　The prosecutor did not explain whether the money later flowed to a special account. However, she said that when she received the money involved, she had received a check with an amount of 24.7087 million yuan. The defense lawyer asked for verification in court, but the prosecutor did not show it.

　　Three cars, including BMW, were transferred to the General Office of the Provincial Discipline Inspection Commission.

　　Chen Yichao and his wife did not expect that although they walked out of the residence where they lived under surveillance, their three cars were transferred to the General Office of the Gansu Provincial Commission for Discipline Inspection. The three cars are BMW compact car, Pajero compact off-road bus and Audi Q7 compact off-road bus. The license plates are Shanghai FL8996, Beijing EP7763 and Beijing KX0829 respectively.

　　China Youth Daily Zhongqing Online reporter confirmed from official sources that the owners of these three cars were originally Chen Yichao, but they were all changed to "General Office of Gansu Provincial Commission for Discipline Inspection".

　　In fact, the transfer of vehicle ownership has already begun before the investigation stage is over. In late December 2011, the first car completed the ownership transfer procedure, and the next day, the Anti-Corruption Bureau of Ganzhou District Procuratorate just formed the Investigation End Report.

　　At the beginning of January 2012, the last car was transferred to the name of the General Office of the Commission for Discipline Inspection. However, two months later, the Zhangye City Procuratorate handed over Chen Yichao’s bribery case to the Ganzhou District Procuratorate for review and prosecution.

　　According to official sources, the registration of each car was transferred from Beijing and Shanghai on the day when the transfer formalities were completed. In the summer of 2012, BMW and Audi cars underwent annual inspection, which means that the new owners may have used the vehicles.

　　In 1998, the Notice of the Commission for Discipline Inspection and the Ministry of Supervision of the CPC Central Committee on Strengthening the Management of Confiscation and Recovery of Illegal Funds and Articles by Discipline Inspection and Supervision Organs stipulated that all confiscated and recovered funds and articles handled by the case-handling offices should be handed over to the financial department of the organ for unified management, and the financial department of the organ should be managed by a special person and set up a special account; Temporary detention and storage of funds and materials should also be properly managed by special personnel; No interception, misappropriation, embezzlement or private sharing is allowed.

　　According to Chen Yichao’s statement in court, the transfer procedures of these three cars were handled by the case handlers with their official seals in Beijing and Shanghai at the end of 2011. The prosecutor did not comment on this.

　　For the reason of "transfer before judgment", some media recently contacted some case handlers of the Gansu Provincial Commission for Discipline Inspection, but they were rejected. On the afternoon of April 15, the relevant office phone number of Gansu Provincial Commission for Discipline Inspection was not answered.

　　Two other cars were also accused of involvement. Lawyer Zhu Xiaoding introduced that the cars were Audi A6L sedan and Toyota Camry sedan, and the license plates were Jing HL4986 and Jing NR1807 respectively. They were transferred to Dong Shaohua and Ma Jian around the end of 2011. The reporter confirmed this statement from official sources.

　　Zhu Xiaoding asked the public prosecutor to issue the identity information of Dong Shaohua and Ma Jian, but the public prosecutor did not produce it. The public prosecutor later said that if there is a problem with the disposal of property, the defender can directly sue.

　　Insiders of Ganzhou District People’s Procuratorate told China Youth Daily that Ma Jian was a section-level procurator of the hospital, while Dong Shaohua was a driver of the hospital, accounting for the establishment of the workers. However, the name of the driver Dong Shaohua appeared in the "Inquirer" column of an inquiry record on September 20, 2011.

　　"How can the property be transferred to the unit or individual?" Professor Li Chengyan is puzzled. Zhu Lijia, a professor at the National School of Administration, said that before the court ruled, the property involved could only be seized and ownership could not be transferred.

　　The reporter noticed that some of the undertakers and custodians of the case overlapped. Gansu Provincial Commission for Discipline Inspection’s registration forms of temporarily detained and sealed articles on June 10th and 19th, 2011 show that three vehicles were temporarily detained and sealed in these two days, and the investigators were Sun Bing and Bai Zhao Bin, and the custodians were also them. Their names also appear in the "inquirer" or "talker" of several transcripts.

　　If the supervision department of the Central Commission for Discipline Inspection handles the case by itself, this practice is not allowed. In 2007, "Regulations on the Management of Money and Articles Involved in Self-managed Cases by the Supervision Department of the Central Commission for Discipline Inspection (Trial)" requires that the management of money and articles involved must be legal, fair, accurate and timely, the case undertaker and the custodian should be separated, and the case handling department and the custody department should perform their respective duties.

　　The procuratorate refused to check and identify the money involved on the spot.

　　The problem of property was finally exposed in the prosecution stage.

　　Lawyer Zhu Xiaoding found that in July and September, 2015, Ganzhou District Procuratorate issued two identical indictments, both of which claimed to "recover a Toyota Camry from Liu Wenge". However, in December of that year, this car disappeared from the registration form for the transfer and handling of money and materials involved by the Gansu Provincial Commission for Discipline Inspection and the prosecution.

　　In this regard, the public prosecutor explained that Liu Wenge’s case had been finalized in November 2012 and the car had been disposed of. She didn’t issue a handling voucher. In fact, this is the car that was transferred to the name of Dong Shaohua, the driver of the procuratorate in 2011.

　　The aforementioned registration form shows that the money involved in the case was transferred to 24.7087 million yuan, and another 178,900 yuan was turned over to the state treasury. Zhu Xiaoding believes that the case has not yet been decided and there should be no money turned over to the state treasury.

　　In January 2016, the prosecution again issued a change indictment, adding a series of property lists sealed up, detained and frozen by the Gansu Provincial Commission for Discipline Inspection, including three cars that have been transferred to the General Office of the Gansu Provincial Commission for Discipline Inspection.

　　Chen Yichao and his lawyer said that Pajero was purchased in December 2000, which obviously has nothing to do with the bribery case; Another car that was transferred to the name of Ma Jian, a procurator at the official level, is not in the indictment and should be returned.

　　The prosecutor did not respond to this at the trial.

　　The list of withheld money and materials such as vehicles also attracted the attention of defense lawyers. The lawyer said that there are several registration forms and search transcripts of temporarily detained and sealed items on different dates in the file, but there is only one search warrant. The prosecutor admitted that the investigation organ only transferred a search warrant.

　　According to the lawyer, the investigators of many of the aforementioned lists are cadres of the Commission for Discipline Inspection and the witnesses are prosecutors handling cases. According to the judicial interpretation, the case-handling personnel should not be witnesses.

　　Yang Xuelin, a lawyer of Beijing Shouxin Law Firm, pleaded not guilty to Chen Yichao. He believes that Chen Yichao does not have a Beijing hukou, and buying a car is only under the name of Liu Wenge, the former deputy general manager of CITIC Gold Company, not a bribe; Chen Yichao didn’t seek illegal benefits, and Liu Wenge didn’t provide substantial help to Chen before the company was transformed into a private enterprise.

　　The prosecutor insisted that the facts of Chen Yichao’s bribery crime were clear and the evidence was indeed sufficient.

　　In fact, even if he was acquitted, more than four years ago, Chen Yichao’s tens of millions of property had been transferred to the name of the case-handling unit or individual. Legally, these properties were at least once owned by others.

　　On the morning of April 14, Chen Yichao and his defense lawyer proposed to check and identify the money and goods involved, such as the transfer of the temporarily detained vehicle and the vehicle odometer, to determine whether the vehicle has been used after being temporarily detained. They also want to check whether the detained cigarettes and alcohol were originally purchased by Chen Yichao.

　　When the presiding judge asked the public prosecutor for advice, the public prosecutor did not object.

　　Professor Li Chengyan told reporters that many people reported that some corruption control departments, such as customs, made a fortune because of their governance. "Sometimes, it is right to confiscate the money and goods involved, but where the money flows is a new problem. Some are distributed internally, and some even take it for resale. "

　　However, on the morning of April 15, Chen Yichao made his final statement, and the defense lawyer asked the court to arrange to check the money and materials involved, but the prosecutor refused, and the defense lawyer then protested.

　　After a 10-minute recess, the presiding judge relayed the prosecutor’s reply after asking the leaders of the procuratorate: the procuratorate did not agree to show the money and materials involved in the case in court, nor did it agree to arrange for on-site inspection.

　　Newspaper, Zhangye, Gansu, April 15th